Please Scroll Down to See Forums Below LETHAL BURN
New member
Is it ok to take 600mlg of ala ed with 5mg of creatine? And is 600mlg enough for insulin effects?
.jpg "Research Chemical Sciences")
.png "Research Chemical Sciences")
alpha lipoic acid and creatine
- Thread starter LETHAL BURN
- Start date
LETHAL BURN
New member
bump.....anyone?
H
HighIntensity
Guest
bmp it up to 800mgs
riskybizz007
New member
I think 200mg at one sitting is the bare minimum. And by the end of the day you should have at least 600mg minimum. 800 like H.I. said would be better.
Alpha Lipoic Acid (ALA) is a unique nutrient shown to have a potent effect on
glucose disposal. It is also a natural antioxidant with free radical scavenging
abilities as well as the ability to regenerate oxidized antioxidants. This
actually makes other antioxidants more potent.
ALA also increases the levels of intra-cellular glutathione. Glutathione has
been shown to enhance recovery from heavy training by reducing intra-cellular
damage.
ALA's ability to enhance glucose uptake is a very exciting effect that could
enhance other nutrient distribution. By mimicking insulin, ALA increases uptake
of glucose into the muscle cell by 65%. This glucose transport stimulation is
accomplished through Lipoic Acid's participation in the insulin signaling
pathway. Lipoic Acid provokes an upward shift of the glucose-insulin
dose-response curve. This is an important function that enhances muscle cell
nutrient uptake and protein turnover.
ALA may also increase creatine's ability to enter the muscle cell further
enhancing creatine's muscle building effects.
Alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations
and improves glucose effectiveness in lean and obese patients with type 2
diabetes.
Konrad T; Vicini P; Kusterer K; H¨oflich A; Assadkhani A; B¨ohles HJ; Sewell A;
Tritschler HJ; Cobelli C; Usadel KH
Department of Internal Medicine, J.W. Goethe-University, Frankfurt, Germany.
Diabetes Care, 22(2):280-7 1999 Feb
Abstract:
OBJECTIVE:
We examined the effect of lipoic acid (LA), a cofactor of the pyruvate
dehydrogenase complex (PDH), on insulin sensitivity (SI) and glucose
effectiveness (SG) and on serum lactate and pyruvate levels after oral glucose
tolerance tests (OGTTs) and modified frequently sampled intravenous glucose
tolerance tests (FSIGTTs) in lean (n = 10) and obese (n = 10) patients with type
2 diabetes.
RESEARCH DESIGN AND METHODS:
FSIGTT data were analyzed by minimal modeling technique to determine SI and SG
before and after oral treatment (600 mg, twice a day, for 4 weeks). Serum
lactate and pyruvate levels of diabetic patients after glucose loading were
compared with those of lean (n = 10) and obese (n = 10) healthy control subjects
in which SI and SG were also determined from FSIGTT data.
RESULTS:
Fasting lactate and pyruvate levels were significantly increased in patients
with type 2 diabetes. These metabolites did not exceed elevated fasting
concentrations after glucose loading in lean patients with type 2 diabetes.
However, a twofold increase of lactate and pyruvate levels was measured in obese
diabetic patients. LA treatment was associated with increased SG in both
diabetic groups (lean 1.28 +/- 0.14 to 1.93 +/- 0.13; obese 1.07 +/- 0.11 to
1.53 +/- 0.08 x 10(-2) min-1, P < 0.05). Higher SI and lower fasting glucose
were measured in lean diabetic patients only (P < 0.05). Lactate and pyruvate
before and after glucose loading were approximately 45% lower in lean and obese
diabetic patients after LA treatment.
CONCLUSIONS:
Treatment of lean and obese diabetic patients with LA prevents
hyperglycemia-induced increments of serum lactate and pyruvate levels and
increases SG.
-Stew
Last edited by Stew Meat on 02-May-2001 at 02:19 AM
Stew Meat
Pro Bodybuilder
Registered: Jul 2000
Location: Louisiana
Posts: 1195
I recomend 500mg/day.
ALA mimics insulin. It works in the same way that insulin does by shuttling
glucose into the muscle cells. It doesn't matter if you are a diabetic or not,
it works like insulin. There's no difference in the cells of a diabetic and
non-diabetic.
-Stew
Alpha Lipoic Acid (ALA) is a unique nutrient shown to have a potent effect on
glucose disposal. It is also a natural antioxidant with free radical scavenging
abilities as well as the ability to regenerate oxidized antioxidants. This
actually makes other antioxidants more potent.
ALA also increases the levels of intra-cellular glutathione. Glutathione has
been shown to enhance recovery from heavy training by reducing intra-cellular
damage.
ALA's ability to enhance glucose uptake is a very exciting effect that could
enhance other nutrient distribution. By mimicking insulin, ALA increases uptake
of glucose into the muscle cell by 65%. This glucose transport stimulation is
accomplished through Lipoic Acid's participation in the insulin signaling
pathway. Lipoic Acid provokes an upward shift of the glucose-insulin
dose-response curve. This is an important function that enhances muscle cell
nutrient uptake and protein turnover.
ALA may also increase creatine's ability to enter the muscle cell further
enhancing creatine's muscle building effects.
Alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations
and improves glucose effectiveness in lean and obese patients with type 2
diabetes.
Konrad T; Vicini P; Kusterer K; H¨oflich A; Assadkhani A; B¨ohles HJ; Sewell A;
Tritschler HJ; Cobelli C; Usadel KH
Department of Internal Medicine, J.W. Goethe-University, Frankfurt, Germany.
Diabetes Care, 22(2):280-7 1999 Feb
Abstract:
OBJECTIVE:
We examined the effect of lipoic acid (LA), a cofactor of the pyruvate
dehydrogenase complex (PDH), on insulin sensitivity (SI) and glucose
effectiveness (SG) and on serum lactate and pyruvate levels after oral glucose
tolerance tests (OGTTs) and modified frequently sampled intravenous glucose
tolerance tests (FSIGTTs) in lean (n = 10) and obese (n = 10) patients with type
2 diabetes.
RESEARCH DESIGN AND METHODS:
FSIGTT data were analyzed by minimal modeling technique to determine SI and SG
before and after oral treatment (600 mg, twice a day, for 4 weeks). Serum
lactate and pyruvate levels of diabetic patients after glucose loading were
compared with those of lean (n = 10) and obese (n = 10) healthy control subjects
in which SI and SG were also determined from FSIGTT data.
RESULTS:
Fasting lactate and pyruvate levels were significantly increased in patients
with type 2 diabetes. These metabolites did not exceed elevated fasting
concentrations after glucose loading in lean patients with type 2 diabetes.
However, a twofold increase of lactate and pyruvate levels was measured in obese
diabetic patients. LA treatment was associated with increased SG in both
diabetic groups (lean 1.28 +/- 0.14 to 1.93 +/- 0.13; obese 1.07 +/- 0.11 to
1.53 +/- 0.08 x 10(-2) min-1, P < 0.05). Higher SI and lower fasting glucose
were measured in lean diabetic patients only (P < 0.05). Lactate and pyruvate
before and after glucose loading were approximately 45% lower in lean and obese
diabetic patients after LA treatment.
CONCLUSIONS:
Treatment of lean and obese diabetic patients with LA prevents
hyperglycemia-induced increments of serum lactate and pyruvate levels and
increases SG.
-Stew
Last edited by Stew Meat on 02-May-2001 at 02:19 AM
Stew Meat
Pro Bodybuilder
Registered: Jul 2000
Location: Louisiana
Posts: 1195
I recomend 500mg/day.
ALA mimics insulin. It works in the same way that insulin does by shuttling
glucose into the muscle cells. It doesn't matter if you are a diabetic or not,
it works like insulin. There's no difference in the cells of a diabetic and
non-diabetic.
-Stew
LETHAL BURN
New member
GREAT POST BROS. THANKS
riskybizz007
New member
I sure it doesn't... but can't give you a technical long explanation answer for it. It does not directly affect insulin levels while on or off, so there should not be a problem, it just makes insulin more sensitive. And personally speaking, I wouldn't take insulin just for that same reason. Think about oral hypoglycemics, they don't shut down your insulin production. In order to do that you need insulin.
Last edited:
