All liquid T3 Bogus?

[galaxy]

Posted this before but the thread got deleted or something? Still looking to keep the discussion of this topic going.


American Journal of Health-System Pharmacy
Current Issue Archive



May 15, 1996, 53:10 > Stability of an extemporaneously... < Previous | Next >

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Fulltext
Stability of an extemporaneously compounded levothyroxine sodium oral liquid.

Report

American Journal of Health-System Pharmacy. 53(10):1157-1161, May 15, 1996.
Boulton, David W.; Fawcett, J. Paul; Woods, David J.
Abstract:
The stability of levothyroxine sodium in oral liquid dosage forms compounded from commercially available tablets was studied.

Levothyroxine sodium oral liquids (25 micro gram/mL) were prepared from tablets and from powder with and without methylparaben preservative and transferred to amber, high-density polyethylene bottles. Five bottles of each tablet-based formulation were stored at 2-8 degrees Celsius, 23-27 degrees Celsius, and 38-42 degrees Celsius, and five bottles of each powder-based formulation were stored at 38-42 degrees Celsius. On days 3, 8, 14, 22, 31, 61, and 90, samples were taken from each bottle and analyzed for drug concentration by stability-indicating high-performance liquid chromatography.

There was significant degradation of levothyroxine sodium in all the formulations.However, the tablet-based formulation without preservative stored at 4 degrees Celsius retained at least 90% of its initial concentration for eight days after compounding. Degradation occurred faster in the tablet-based formulation with preservative. None of the formulations retained greater or equal to 90% initial potency by day 14.

An extemporaneous oral liquid formulation of levothyroxine sodium 25 micro gram/mL compounded from crushed tablets was stable for eight days when stored in amber bottles at 4 degrees Celsius.

Am J Health-Syst Pharm. 1996; 53:1157-61.

Copyright (C) 1996 American Society of Health-System Pharmacists, Inc. All rights reserved.

 

[X Man]

Posted this before but the thread got deleted or something? Still looking to keep the discussion of this topic going.


American Journal of Health-System Pharmacy
Current Issue Archive



May 15, 1996, 53:10 > Stability of an extemporaneously... < Previous | Next >

ARTICLE LINKS:
Fulltext
Stability of an extemporaneously compounded levothyroxine sodium oral liquid.

Report

American Journal of Health-System Pharmacy. 53(10):1157-1161, May 15, 1996.
Boulton, David W.; Fawcett, J. Paul; Woods, David J.
Abstract:
The stability of levothyroxine sodium in oral liquid dosage forms compounded from commercially available tablets was studied.

Levothyroxine sodium oral liquids (25 micro gram/mL) were prepared from tablets and from powder with and without methylparaben preservative and transferred to amber, high-density polyethylene bottles. Five bottles of each tablet-based formulation were stored at 2-8 degrees Celsius, 23-27 degrees Celsius, and 38-42 degrees Celsius, and five bottles of each powder-based formulation were stored at 38-42 degrees Celsius. On days 3, 8, 14, 22, 31, 61, and 90, samples were taken from each bottle and analyzed for drug concentration by stability-indicating high-performance liquid chromatography.

There was significant degradation of levothyroxine sodium in all the formulations.However, the tablet-based formulation without preservative stored at 4 degrees Celsius retained at least 90% of its initial concentration for eight days after compounding. Degradation occurred faster in the tablet-based formulation with preservative. None of the formulations retained greater or equal to 90% initial potency by day 14.

An extemporaneous oral liquid formulation of levothyroxine sodium 25 micro gram/mL compounded from crushed tablets was stable for eight days when stored in amber bottles at 4 degrees Celsius.

Am J Health-Syst Pharm. 1996; 53:1157-61.

Copyright (C) 1996 American Society of Health-System Pharmacists, Inc. All rights reserved.

someone i know lost 23 ppounds of chemon research t-3....didnt ulter his diet like many on here would or do regular cardio like many on here do..... idk whut it was that was actually in the liquid but it made him loose weight

 

[Mr.X]

Posted this before but the thread got deleted or something? Still looking to keep the discussion of this topic going.


American Journal of Health-System Pharmacy
Current Issue Archive



May 15, 1996, 53:10 > Stability of an extemporaneously... < Previous | Next >

ARTICLE LINKS:
Fulltext
Stability of an extemporaneously compounded levothyroxine sodium oral liquid.

Report

American Journal of Health-System Pharmacy. 53(10):1157-1161, May 15, 1996.
Boulton, David W.; Fawcett, J. Paul; Woods, David J.
Abstract:
The stability of levothyroxine sodium in oral liquid dosage forms compounded from commercially available tablets was studied.

Levothyroxine sodium oral liquids (25 micro gram/mL) were prepared from tablets and from powder with and without methylparaben preservative and transferred to amber, high-density polyethylene bottles. Five bottles of each tablet-based formulation were stored at 2-8 degrees Celsius, 23-27 degrees Celsius, and 38-42 degrees Celsius, and five bottles of each powder-based formulation were stored at 38-42 degrees Celsius. On days 3, 8, 14, 22, 31, 61, and 90, samples were taken from each bottle and analyzed for drug concentration by stability-indicating high-performance liquid chromatography.

There was significant degradation of levothyroxine sodium in all the formulations.However, the tablet-based formulation without preservative stored at 4 degrees Celsius retained at least 90% of its initial concentration for eight days after compounding. Degradation occurred faster in the tablet-based formulation with preservative. None of the formulations retained greater or equal to 90% initial potency by day 14.

An extemporaneous oral liquid formulation of levothyroxine sodium 25 micro gram/mL compounded from crushed tablets was stable for eight days when stored in amber bottles at 4 degrees Celsius.

Am J Health-Syst Pharm. 1996; 53:1157-61.

Copyright (C) 1996 American Society of Health-System Pharmacists, Inc. All rights reserved.

I've used liquid T3 , had great results. All my clients use liquids - with great results. IMO, I think in the long-run it's all about quality of powder and handling, pretty much what it boils down to.

See my views about studies and how they are mostly false in the first place.
http://www.forums.isteroids.com/ana...23284-important-studies-false-misleading.html

You have an Abstract posted here, until the whole study is up, hard to say anything.

 

[black sheep]

It does make me curious, I must say. We (those of us on the AAS Forum) should start pitching in to test random products. I would be willing to pitch in for the cost of a lab test for some liquid T3. We could settle this debate once and for all.

 

[c3bodybuilding]

But I thought it would be naive to trust a board to lab test products...

 

[macrophage69alpha]

But I thought it would be naive to trust a board to lab test products...

talk to ulter, he could set something up. He used to do a lot of testing, bill llewellyn used a lot of anafits tests in his book, not as much lately but still on occasion

 

[Mr.X]

But I thought it would be naive to trust a board to lab test products...

There were many situations where this was a problem. Offshore tested some HCL stuff, turned out they diluted the bottle, so you make a good point.

IMO, reality is always somewhere in between. Anyone who used liquid t3 from a legit co. knows it works and it works well.

 

[black sheep]

talk to ulter, he could set something up. He used to do a lot of testing, bill llewellyn used a lot of anafits tests in his book, not as much lately but still on occasion

Yeah... that is who I had in mind. I have had lab tests done thru ulter.

It is naive to think that a BOARD would lab test a product on their own, one that was supplied by a steroid maker. Of Course it is going to be sopt on


I am not doubting that any of the liquid research product manufacturers are properly dosesing their products properly, that would not be the point of this test. The point would be to test a Liquid T3 that is a little older (30+ days) and see if the level is degraded any from the original level.

 

[c3bodybuilding]

I don't doubt that Blacksheep. But most of the mods at outlaw are trusted bro's and vets on here as well, like Muscleup. And the products are donated by members and the lab test are paid with donations. Sort of how like Ulter helps us out with lab tests here. But I do understand what you meant, I was just being a bit of a prick. Karma bro

 

[mendo]

I would be more concerned except for one thing. I am in the middle of a t-3 cycle that started out as pills, then I switched to liquid after a couple weeks, then I missed 5 days (stupid I know), then I started back up with a diff brand of liquid.
Here's what I noticed: my metabolism increased the first day (way more shits ) and it stayed the same with the liquid, then it slowed way down when I stopped the t-3 for 5 days and increased again with the other brand of liquid. So the liquid t-3 is legit in my book.

 

[black sheep]

I would be more concerned except for one thing. I am in the middle of a t-3 cycle that started out as pills, then I switched to liquid after a couple weeks, then I missed 5 days (stupid I know), then I started back up with a diff brand of liquid.
Here's what I noticed: my metabolism increased the first day (way more shits ) and it stayed the same with the liquid, then it slowed way down when I stopped the t-3 for 5 days and increased again with the other brand of liquid. So the liquid t-3 is legit in my book.

I am using AG Liquid T3 right now along side my rHGH. I too can tell that it works, no doubt about that fact. I am sure that AG uses a carrier that keeps the product from degrading - They are good Bros. I sould just be curious what a bottle say 6 months old tests out like...

 

[ItalianMuscle27]

I personally would only use a humangrade version..

 

[macrophage69alpha]

I would be more concerned except for one thing. I am in the middle of a t-3 cycle that started out as pills, then I switched to liquid after a couple weeks, then I missed 5 days (stupid I know), then I started back up with a diff brand of liquid.
Here's what I noticed: my metabolism increased the first day (way more shits ) and it stayed the same with the liquid, then it slowed way down when I stopped the t-3 for 5 days and increased again with the other brand of liquid. So the liquid t-3 is legit in my book.

t3 (liothyronine sodium) has a half life of 2.5 days, so it should not have slowed "way down" in that short a period. Now if they are using triiodothyronine(t3)- which is highly unlikely, then it would need to be used twice a day because of short half life (and pretty sure that form is much less stable in solution than sodium bound)

 

[Anthony Roberts]

AG goes through several steps to insure quality control for all of their products. If there was a problem (which there isn't) they'd be the first to know, and rectify it.

It comes down to quality control, and knowing who you're buying from.

There's a reason AG has been around for years and years...

 

[slimsc]

anthony,
that is good to know agout AG... My lab rat is needing some clen/t3...

​

 

[mendo]

t3 (liothyronine sodium) has a half life of 2.5 days, so it should not have slowed "way down" in that short a period. Now if they are using triiodothyronine(t3)- which is highly unlikely, then it would need to be used twice a day because of short half life (and pretty sure that form is much less stable in solution than sodium bound)

I see you're point macro. All I can say is maybe it was a placebo effect, because I def felt a big difference after being off for 5 days.

 

[Twoguns]

I would be more concerned except for one thing. I am in the middle of a t-3 cycle that started out as pills, then I switched to liquid after a couple weeks, then I missed 5 days (stupid I know), then I started back up with a diff brand of liquid.
Here's what I noticed: my metabolism increased the first day (way more shits ) and it stayed the same with the liquid, then it slowed way down when I stopped the t-3 for 5 days and increased again with the other brand of liquid. So the liquid t-3 is legit in my book.

Dude, fucking with T-3 like that is dangerous as hell. I know I don't want to be on synthroid my whole life.

 

[MTS]

It's kind of interesting because i used synthroid tabs and got slightly better results then liquid T-3....Im not saying the T-3 didnt work but rather not quite as well

 

[Prizz]

Dude, fucking with T-3 like that is dangerous as hell. I know I don't want to be on synthroid my whole life.

Oh come now.... T3 only becomes dangerous with High doses, or long term use..... What he described is hardly "Fucking with T3"..... If you know me at all, I always preach safety, so it's good youre so cautious, but T3 isn't has harmfull as most guys think....

I also tend to think Liquid T3 isn't good to keep around a long time.... Prob best to order it, and use it ASAP.... Don't let it sit on the shelf for a while.....


rizz

 

[Big O]

t-3 is good especially if it's mg'd in lower doses....make the pyramid even smoother....
i use it for 8 weeks straight...i never do the 2 and 2....not syaing its better or what ever...maybe its smarter to go 2 and 2...seems it would be less stressfull on thenite sweets and cramping....
who uses the 2 & 2

 

[Dellyo]

It does make me curious, I must say. We (those of us on the AAS Forum) should start pitching in to test random products. I would be willing to pitch in for the cost of a lab test for some liquid T3. We could settle this debate once and for all.

Sounds good to me.....

 

[mendo]

Dude, fucking with T-3 like that is dangerous as hell. I know I don't want to be on synthroid my whole life.

The thing about t-3 is that you are either sensitive to swings in t-3 levels or you're not. This is what I've observed in the guys I know. A lot of people can start and stop t-3 at a high dose without ramping...or run it for extended periods with no probs at all. Apparenty there are cases where some people need to be very careful or they can shut down their thyroid. This isn't everyone though. Obviously the danger is that most people don't know if they are prone to thyroid issues or not.

 

[Twoguns]

Oh come now.... T3 only becomes dangerous with High doses, or long term use..... What he described is hardly "Fucking with T3"..... If you know me at all, I always preach safety, so it's good youre so cautious, but T3 isn't has harmfull as most guys think....

I also tend to think Liquid T3 isn't good to keep around a long time.... Prob best to order it, and use it ASAP.... Don't let it sit on the shelf for a while.....


rizz

Post was in general not directed at you in particular. I got real fucked up on this shit and took me along time to bounce back. That's all. Not criticizing you

 

[Prizz]

Post was in general not directed at you in particular. I got real fucked up on this shit and took me along time to bounce back. That's all. Not criticizing you

Oh no man, i didn't think so..... I was just saying T3 is a hormone, and not to be fucked with, but I dont think it's as dangerous as rumored to be.... I mean, as long as you taper up and down, keep your cycles not too long, youre ok..... Sorry you had trouble with it.... I did too actually, like years ago when i didn't know shit about it.... Fucked up my metabolism for Months....

rizz

 

[dsh89]

I am just coming off a liquid T3 cycle of 5 weeks and man it was unbelievable. I am seeing veins I never have seen before. I could completely tell the liquid T3 worked. I would be sweating my ass off just standing in an air conditioned room lol. I have no doubt that liquid T3 is legit.

 

[Twoguns]

Oh no man, i didn't think so..... I was just saying T3 is a hormone, and not to be fucked with, but I dont think it's as dangerous as rumored to be.... I mean, as long as you taper up and down, keep your cycles not too long, youre ok..... Sorry you had trouble with it.... I did too actually, like years ago when i didn't know shit about it.... Fucked up my metabolism for Months....

rizz

same thing happened to me, some mexican cynomel shit. I had to confess to my doc who ripped me a new ass. he monitored my thyroid levels and it took like four months to get back to normal without meds. I gained so much fat during that time.