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ALA vs. R-ALA
- Thread starter JKurz1
- Start date
No. Unfortunately the synthetic half (S) of regular (Racemic) ALA inhibits the natural half (R) because it competes with it and gets in it's way. Regular (Racemic) ALA should be avoided.
What the researchers say who have worked with both regular and R+.
"We're finding - and others are, too - that the R(+)-form - the natural form - is much more powerful than the racemic mixture ... Hopefully ... companies are going to be producing on more of a clinical scale the R(+)-form of lipoic acid, because we're finding very significant effects using this, as opposed to the racemic mixture."
Dr. Tory Hagen, in Mitochondrial Decay in Aging.
"We have presented in this study new information indicating that this enhancement of glucose metabolism is sterospecific, with the R(+)-enantiomer being much more effective than the S(-)- enantiomer."
Dr. Ryan Streeper and colleagues, in The American Journal of Physiology.
"Lipoic acid sold in a health food store is a synthetic mixture, a racemic mixture. And R[+]- is the natural form and S[-]- is an unnatural one ... And in our hands R[+]- works and S[-]- doesn't."
Dr. Bruce Ames, in Strategies for Engineered Negligible Senescence.
"R[+]-LA [that is, R(+)-lipoic acid], and not a racemic mixture of R[+]-and S[-]- LA, should be considered a choice for therapeutic applications."
Dr. Lester Packer and colleagues, in Free Radical Biology and Medicine.
"The S[-]-enantiomer … part of the racemate, which is present as about a 50% impurity, needs to be eliminated."
Dr. Guido Zimmer and colleagues, in Methods in Enzymoogy.
What the researchers say who have worked with both regular and R+.
"We're finding - and others are, too - that the R(+)-form - the natural form - is much more powerful than the racemic mixture ... Hopefully ... companies are going to be producing on more of a clinical scale the R(+)-form of lipoic acid, because we're finding very significant effects using this, as opposed to the racemic mixture."
Dr. Tory Hagen, in Mitochondrial Decay in Aging.
"We have presented in this study new information indicating that this enhancement of glucose metabolism is sterospecific, with the R(+)-enantiomer being much more effective than the S(-)- enantiomer."
Dr. Ryan Streeper and colleagues, in The American Journal of Physiology.
"Lipoic acid sold in a health food store is a synthetic mixture, a racemic mixture. And R[+]- is the natural form and S[-]- is an unnatural one ... And in our hands R[+]- works and S[-]- doesn't."
Dr. Bruce Ames, in Strategies for Engineered Negligible Senescence.
"R[+]-LA [that is, R(+)-lipoic acid], and not a racemic mixture of R[+]-and S[-]- LA, should be considered a choice for therapeutic applications."
Dr. Lester Packer and colleagues, in Free Radical Biology and Medicine.
"The S[-]-enantiomer … part of the racemate, which is present as about a 50% impurity, needs to be eliminated."
Dr. Guido Zimmer and colleagues, in Methods in Enzymoogy.
CLOMIDCLOWN
New member
Utler, is this "competition" similar to the ala vs biotin competition in any way?
macrophage69alpha
New member
CLOMIDCLOWN said:
no.
Lipoic acid and biotin do not actually compete, thier interaction is secondary. Hence, why the addition of extra biotin alleviates this.
R and S isomers directly compete for tissue uptake, with S having low uptake and blocking R uptake
see here
Biochem Biophys Res Commun. 1996 Apr 16;221(2):422-9. Related Articles, Links
Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats.
Maitra I, Serbinova E, Tritschler HJ, Packer L.
Department of Molecular and Cell Biology, University of California, Berkeley, 94720-3200, USA.
This study revealed a marked stereospecificity in the prevention of buthionine sulfoximine-induced cataract, and in the protection of lens antioxidants, in newborn rats by alpha-lipoate, R- and racemic alpha-lipoate decreased cataract formation from 100% (buthionine sulfoximine only) to 55% (buthionine sulfoximine + R-alpha-lipoic acid) and 40% (buthionine sulfoximine + rac-alpha-lipoic acid) (p<0.05 compared to buthionine sulfoximine only). S-alpha-lipoic acid had no effect on cataract formation induced by buthionine sulfoximine. The lens antioxidants glutathione, ascorbate, and vitamin E were depleted to 45, 62, and 23% of control levels, respectively, by buthionine sulfoximine treatment, but were maintained at 84-97% of control levels when R-alpha-lipoic acid or rac-alpha-lipoic acid were administered with buthionine sulfoximine; S-alpha-lipoic acid administration had no protective effect on lens antioxidants. When enantiomers of alpha-lipoic acid were administered to animals, R-alpha-lipoic acid was taken up by lens and reached concentrations 2- to 7-fold greater than those of S-alpha-lipoic acid, with rac-alpha-lipoic acid reaching levels midway between the R-isomer and racemic form. Reduced lipoic acid, dihydrolipoic acid, reached the highest levels in lens of the rac-alpha-lipoic acid-treated animals and the lowest levels in S-alpha-lipoic acid-treated animals. These results indicate that the protective effects of alpha-lipoic acid against buthionine sulfoximine-induced cataract are probably due to its protective effects on lens antioxidants, and that the stereospecificity exhibited is due to selective uptake and reduction of R-alpha-lipoic acid by lens cells.
CLOMIDCLOWN
New member
Thanks macro!
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