Please Scroll Down to See Forums Below 
biggerthanu450
New member
Check out this info on Alpha lipoic acid.
I bought some from DPSnutrition, but found excellent deals on ALA on www.ebay.com
OVERVIEW
Alpha lipoic acid, (also known as lipoic acid, thioctic acid) is a sulfur-containing vitamin-like antioxidant. Alpha lipoic acid is produced naturally in the body and found in the food sources of liver, brewer’s yeast, and potatoes. Alpha lipoic acid has dual role in human health; it is a powerful antioxidant and is a key component for producing cellular energy. As an antioxidant, alpha lipoic acid is unique in that it is both water- and fat-soluble; thus it can be used throughout the body. It also extends and enhances the effect of other antioxidants, which are used to defend the body against free radical damage. In its metabolic role, alpha lipoic acid is a fundamental coenzyme in two vital reactions that lead to the production of cellular energy (ATP). Alpha lipoic acid was first isolated in 1957, and originally, seemed to be a member of the vitamin B–complex. Alpha lipoic acid would have been the first fat-soluble B vitamin isolated. Most human coenzymes are produced from some of the B-complex vitamins or are themselves vitamins (Passwater, 1995). Alpha lipoic acid is not considered a vitamin, but is termed a "conditionally essential" nutrient. This is because presumably the body can produce sufficient levels or it is acquired in sufficient quantities from food (Murray, 1996). The human body can make enough alpha lipoic acid to prevent a recognizable deficiency disease, though not enough to perform all its functions. The optimal level of alpha lipoic acid varies with each person depending on biochemical differences, lifestyle, exercise and how much oxidative stress they experience. Certain diseases, environmental conditions and age can cause a deficiency in lipoic acid, and thus the body often doesn’t make enough to meet all its metabolic and antioxidant needs.
METHOD OF ACTION
Alpha lipoic acid is involved in the metabolic process of converting carbohydrates into energy. When sugar is metabolized in the production of energy, it is converted into pyruvic acid. The pyruvate is broken down by an enzyme complex that contains lipoic acid, niacin and thiamin. Since the human body tends to have only the minimum amount of alpha lipoic acid to prevent recognizable disease, supplementation may help improve energy metabolism. This is particularly applicable in people with lower than normal levels, for example, individuals with diabetes, liver cirrhosis, heart disease and HIV.
As an antioxidant, since alpha lipoic acid is both water- and fat-soluble it is effective against a broader range of free radicals than vitamin C (water soluble) and vitamin E (fat-soluble). Because of it unique size and chemical structure, lipoic acid has access to virtually the entire body, whereas most antioxidants only protect isolated areas of the body. Inside the cell, alpha lipoic acid is quickly broken down to dihydrolipoic acid, and even more potent free-radical scavenger. Supplementation with lipoic acid wards off scurvy (vitamin C deficiency).
THERAPEUTIC APPROACHES
The principal uses of alpha lipoic acid are in the treatment of diabetes and HIV/AIDS. It has also been used in cases of liver cirrhosis, heart disease, cataracts, heavy-metal toxicity and detoxification support.
Alpha lipoic acid is available in supplemental form of tablets and capsules. For use as a general antioxidant, the recommended dose is 20 to 50 mg daily. In the treatment of diabetes, the recommended dose is 300 to 600 mg daily. In the treatment of AIDS, the recommended dose is 150 mg three times daily (Murray, 1996). Although lipoic acid deficiency states have not been demonstrated in human beings, animal studies show that a deficiency of lipoic acid results in reduced muscle mass, brain atrophy, failure to thrive and increased lactic acid accumulation.
DIABETES
Alpha lipoic acid has been used in Europe for over three decades to treat diabetic neuropathy, to help regulate blood sugar, and prevent diabetic retinopathy and cardiopathy. Alpha lipoic acid is an approved drug in Germany for the treatment of diabetic neuropathy. Alpha lipoic acid normalizes blood sugar levels in diabetics and also reduces the secondary effects of diabetes, including retinopathy, cataract formation, nerve and heart damage, as well as increasing energy levels. It is used in the treatment of both insulin-dependent and non-insulin dependent diabetes. Alpha lipoic acid helps control blood sugar by facilitating the conversion of sugar into energy. Alpha lipoic acid reduces glycation (also known as glycosylation), which is the process in which proteins react with excess glucose. This sugar reaction to protein is just as detrimental as oxygen damage (free radical damage). Alpha lipoic acid helps to keep blood sugar levels under control and reduced levels of glucose mean less glycation. This is important in reducing diabetic side effects and slowing aging. In summary, alpha lipoic acid’s effect on diabetes is through its potent antioxidant capabilities, as well improving blood sugar metabolism, reducing glycosylation of proteins, improving blood flow to the peripheral nerves, and actually stimulating regeneration of nerve fibers (Wagh, 1987).
AIDS
Individuals infected with the HIV virus tend to have a compromised antioxidant defense system. During HIV infection, key cells of the immune system called CD lymphocytes lose their ability to make and to transport glutathione. Antioxidants such as glutathione prevent HIV viral replication while reactive oxidants tend to stimulate the virus. Glutathione is a major cellular antioxidant, and thus, the CD lymphocytes are exposed to excess oxidative stress and this contributes to immune system failure. Alpha lipoic acid is a powerful antioxidant and facilitator of glutathione production. A strong antioxidant defense system can help prevent this oxidative damage and help keep the immune system strong.
A study was conducted by Dr. Fuchs and colleagues, to determine the short-term effect of supplemental lipoic acid. Alpha lipoic acid was given as a supplement (150 mg three times daily for a two week period) to HIV-infected patients. Lipoic acid supplementation increased total glutathione in seven of seven patients, plasma ascorbate in nine of ten patients, total plasma sulfur groups in eight of nine patients, and T helper lymphocytes and T helper/suppressor cell ratio in six of ten patients. The conclusion of this study is that lipoic acid supplementation led to significant beneficial changes in the blood of HIV-infected patients (Fuchs, et al., 1993).
Alpha lipoic acid has been beneficial to cancer patients suffering with peripheral neuropathy, a damaging side effect of chemotherapy. Lipoic acid also protects against cancer as a result of its potent antioxidant effects. Lipoic acid protects a complex called Nuclear Factor kappa-B and prevents it from activating oncogenes. Oncogenes are genes that contribute to cancer cell proliferation. When these genes are altered by either NF kappa-B or a carcinogen, they cause the cell to become malignant. Lipoic acid can enter the cytosol of cells and protect NF kappa-B from activation by free radical, radiation, or even sunlight.
Alpha lipoic acid may be helpful in other conditions including Liver cirrhosis, hepatitis, heart disease, cataracts, heavy metal toxicity, and support during detoxification. Its role in detoxification is as a chelator (remover) of heavy metals and toxic minerals from the body.
Alpha lipoic acid protects the nervous system and may be involved in regenerating the nerves. It is being studied in the treatment of Parkinson’s disease and Alzheimer’s disease.
Alpha lipoic acid has been shown to improve antibody response in immunosuppressed animals (Quillin, 1998).
I bought some from DPSnutrition, but found excellent deals on ALA on www.ebay.com
OVERVIEW
Alpha lipoic acid, (also known as lipoic acid, thioctic acid) is a sulfur-containing vitamin-like antioxidant. Alpha lipoic acid is produced naturally in the body and found in the food sources of liver, brewer’s yeast, and potatoes. Alpha lipoic acid has dual role in human health; it is a powerful antioxidant and is a key component for producing cellular energy. As an antioxidant, alpha lipoic acid is unique in that it is both water- and fat-soluble; thus it can be used throughout the body. It also extends and enhances the effect of other antioxidants, which are used to defend the body against free radical damage. In its metabolic role, alpha lipoic acid is a fundamental coenzyme in two vital reactions that lead to the production of cellular energy (ATP). Alpha lipoic acid was first isolated in 1957, and originally, seemed to be a member of the vitamin B–complex. Alpha lipoic acid would have been the first fat-soluble B vitamin isolated. Most human coenzymes are produced from some of the B-complex vitamins or are themselves vitamins (Passwater, 1995). Alpha lipoic acid is not considered a vitamin, but is termed a "conditionally essential" nutrient. This is because presumably the body can produce sufficient levels or it is acquired in sufficient quantities from food (Murray, 1996). The human body can make enough alpha lipoic acid to prevent a recognizable deficiency disease, though not enough to perform all its functions. The optimal level of alpha lipoic acid varies with each person depending on biochemical differences, lifestyle, exercise and how much oxidative stress they experience. Certain diseases, environmental conditions and age can cause a deficiency in lipoic acid, and thus the body often doesn’t make enough to meet all its metabolic and antioxidant needs.
METHOD OF ACTION
Alpha lipoic acid is involved in the metabolic process of converting carbohydrates into energy. When sugar is metabolized in the production of energy, it is converted into pyruvic acid. The pyruvate is broken down by an enzyme complex that contains lipoic acid, niacin and thiamin. Since the human body tends to have only the minimum amount of alpha lipoic acid to prevent recognizable disease, supplementation may help improve energy metabolism. This is particularly applicable in people with lower than normal levels, for example, individuals with diabetes, liver cirrhosis, heart disease and HIV.
As an antioxidant, since alpha lipoic acid is both water- and fat-soluble it is effective against a broader range of free radicals than vitamin C (water soluble) and vitamin E (fat-soluble). Because of it unique size and chemical structure, lipoic acid has access to virtually the entire body, whereas most antioxidants only protect isolated areas of the body. Inside the cell, alpha lipoic acid is quickly broken down to dihydrolipoic acid, and even more potent free-radical scavenger. Supplementation with lipoic acid wards off scurvy (vitamin C deficiency).
THERAPEUTIC APPROACHES
The principal uses of alpha lipoic acid are in the treatment of diabetes and HIV/AIDS. It has also been used in cases of liver cirrhosis, heart disease, cataracts, heavy-metal toxicity and detoxification support.
Alpha lipoic acid is available in supplemental form of tablets and capsules. For use as a general antioxidant, the recommended dose is 20 to 50 mg daily. In the treatment of diabetes, the recommended dose is 300 to 600 mg daily. In the treatment of AIDS, the recommended dose is 150 mg three times daily (Murray, 1996). Although lipoic acid deficiency states have not been demonstrated in human beings, animal studies show that a deficiency of lipoic acid results in reduced muscle mass, brain atrophy, failure to thrive and increased lactic acid accumulation.
DIABETES
Alpha lipoic acid has been used in Europe for over three decades to treat diabetic neuropathy, to help regulate blood sugar, and prevent diabetic retinopathy and cardiopathy. Alpha lipoic acid is an approved drug in Germany for the treatment of diabetic neuropathy. Alpha lipoic acid normalizes blood sugar levels in diabetics and also reduces the secondary effects of diabetes, including retinopathy, cataract formation, nerve and heart damage, as well as increasing energy levels. It is used in the treatment of both insulin-dependent and non-insulin dependent diabetes. Alpha lipoic acid helps control blood sugar by facilitating the conversion of sugar into energy. Alpha lipoic acid reduces glycation (also known as glycosylation), which is the process in which proteins react with excess glucose. This sugar reaction to protein is just as detrimental as oxygen damage (free radical damage). Alpha lipoic acid helps to keep blood sugar levels under control and reduced levels of glucose mean less glycation. This is important in reducing diabetic side effects and slowing aging. In summary, alpha lipoic acid’s effect on diabetes is through its potent antioxidant capabilities, as well improving blood sugar metabolism, reducing glycosylation of proteins, improving blood flow to the peripheral nerves, and actually stimulating regeneration of nerve fibers (Wagh, 1987).
AIDS
Individuals infected with the HIV virus tend to have a compromised antioxidant defense system. During HIV infection, key cells of the immune system called CD lymphocytes lose their ability to make and to transport glutathione. Antioxidants such as glutathione prevent HIV viral replication while reactive oxidants tend to stimulate the virus. Glutathione is a major cellular antioxidant, and thus, the CD lymphocytes are exposed to excess oxidative stress and this contributes to immune system failure. Alpha lipoic acid is a powerful antioxidant and facilitator of glutathione production. A strong antioxidant defense system can help prevent this oxidative damage and help keep the immune system strong.
A study was conducted by Dr. Fuchs and colleagues, to determine the short-term effect of supplemental lipoic acid. Alpha lipoic acid was given as a supplement (150 mg three times daily for a two week period) to HIV-infected patients. Lipoic acid supplementation increased total glutathione in seven of seven patients, plasma ascorbate in nine of ten patients, total plasma sulfur groups in eight of nine patients, and T helper lymphocytes and T helper/suppressor cell ratio in six of ten patients. The conclusion of this study is that lipoic acid supplementation led to significant beneficial changes in the blood of HIV-infected patients (Fuchs, et al., 1993).
Alpha lipoic acid has been beneficial to cancer patients suffering with peripheral neuropathy, a damaging side effect of chemotherapy. Lipoic acid also protects against cancer as a result of its potent antioxidant effects. Lipoic acid protects a complex called Nuclear Factor kappa-B and prevents it from activating oncogenes. Oncogenes are genes that contribute to cancer cell proliferation. When these genes are altered by either NF kappa-B or a carcinogen, they cause the cell to become malignant. Lipoic acid can enter the cytosol of cells and protect NF kappa-B from activation by free radical, radiation, or even sunlight.
Alpha lipoic acid may be helpful in other conditions including Liver cirrhosis, hepatitis, heart disease, cataracts, heavy metal toxicity, and support during detoxification. Its role in detoxification is as a chelator (remover) of heavy metals and toxic minerals from the body.
Alpha lipoic acid protects the nervous system and may be involved in regenerating the nerves. It is being studied in the treatment of Parkinson’s disease and Alzheimer’s disease.
Alpha lipoic acid has been shown to improve antibody response in immunosuppressed animals (Quillin, 1998).
