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Ahletes and THG
- Thread starter Dr. JK
- Start date
Don't know if you saw it yet, but this was on this page.
http://www.elitefitness.com/forum/showthread.php?s=&threadid=274025&highlight=thg
http://www.elitefitness.com/forum/showthread.php?s=&threadid=274025&highlight=thg
Well, how different are boldenone and methandrostenolone from each other? Pretty different aren't they? Putting on a 17-alkyl group changes the binding affinity of the steroid to the AR and it also has effects on the anabolism of the compound. My point is that comparing THG to tren acetate is sort of apples to oranges. A better comparison is 17-methyl-trenbolone to THG; both are 17-alkylated. Although, I would expect the 17-ethyl group on THG to exert a somewhat stronger influence on AR binding than a 17-methyl because of its increased size. That is just an educated guess however. I do not have any data on other 17-ethylated steroids vs. their 17-methylated counterparts.Dr. JK said:
BTW, it is spelled treNbolone
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Spidey said:Well, how different are boldenone and methandrostenolone from each other? Pretty different aren't they? Putting on a 17-alkyl group changes the binding affinity of the steroid to the AR and it also has effects on the anabolism of the compound. My point is that comparing THG to tren acetate is sort of apples to oranges. A better comparison is 17-methyl-trenbolone to THG; both are 17-alkylated. Although, I would expect the 17-ethyl group on THG to exert a somewhat stronger influence on AR binding than a 17-methyl because of its increased size. That is just an educated guess however. I do not have any data on other 17-ethylated steroids vs. their 17-methylated counterparts.
BTW, it is spelled treNbolone
Good info. thanks.
...bd
Sigmund Roid
New member
That is some clever stuff.
During preparation for gass chromatography the stuff decomposes or vaporises, making it invisible in the conventional ways of preparing urine samples. Balco and henchmen were some clever dudes.
During preparation for gass chromatography the stuff decomposes or vaporises, making it invisible in the conventional ways of preparing urine samples. Balco and henchmen were some clever dudes.
Well, yes and no. Anything injected into a gas chromatograph has to vaporize (turn into a gas) in order for it to be carried through the column and detected. That is the whole basis upon which gas chromatography works.Sigmund Roid said:
Compounds travel through the column with a carrier gas (helium). There rate of speed through the column is a function of how well the molecules interact with the column packing; the more the molecule interacts (or sticks to) with the column packing, the slower it travels. This results in different types of molecules in a mixture being separated as a function of travel velocity.
Example: For a mixture of A molecules (trenbolone) and B molecules (THG), The mixture is injected into a small reservoir, heated to very high temperature at the beginning of the column (called the injector port). The mixture vaporizes from the heat and is carried onto the column (also heated) with a stream of helium. Lets say "A" is more polar than "B" and so it "sticks to the column packing a little more tightly than does "B". This means that with a constant helium flow rate, "B" will move faster than "A" and will arrive at the end of the column to be detected before "A". The time that compounds take to reach the end of the column at a given flow rate is called the "retention time". So, "B" might come out at 3 minutes and "A" might come out at 8 minutes. The detector in this case would probably be a mass detector so one could choose any peak on the chromatogram and get a full mass spectrum on it. The mass spectrum of a compound is like a fingerprint; it is unique for every compound. The lab would compare the mass spec fingerprint of the compound in question to those in a library of mass spectra to see if it matched anything. Now, in a normal blood or urine sample, there will be literally hundreds of compounds. In steroid tests, they are looking for a handful of SPECIFIC compounds with known retention times and known mass spec fingerprints. If there is trenbolone in the sample, they will get a peak at retention time = 8 minutes (in my example). The mass spec of the peak at 8 minutes will be compared to a library of steroid mass spec fingerprints. Uh oh, it matches the one for trenbolone; you are busted. The peak at 3 minutes (THG) will most likely simply be ignored because it doesn't match the retention time of any of the known stereoids they are looking for. Even if they did look at it, the mass spec fingerprint would not match up to anything in their library so it would still be disregarded.
THAT'S WHY IT WAS UNDETECTABLE. Simply because they weren't looking for it. They can only detect steroids that they already know exist. Once it was identified, the retention time and mass spec fingerprint were added to the existing library and now it is just as detectable as any other known steroid.
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