I'm using it right now. I'm half way through my third bottle. I do notice my knees a little smoother and overall less painful. The clicking in a few joints is still there. Thing is I'm taking Glucosamine, Chondroitin, MSM, Hyaluronic acid, Bio Cell Collegen2, and HGH. I believe all of it is doing some good. I have pain in knee where the tendon attaches to the kneecap that was painful to the touch that also seems to be getting better. I doubt this is the Adequan though. As you know Adequan just replaces the fluid. Shit does burn going in. I put half a cc in inner and outer quad as close to the knee as possible. I have also done a couple in each shoulder. @ 42yrs. and 24yrs. playing competitive softball in three leagues and weekends my joints need all the help they can get. I don't know if this helps you but I didn't go in just trying to see what works and what doesn't.