A question about insulin:

[SlimJim300]

I would just like someone to either correct me or confirm that when insulin agonizes the alpha-2 receptor it stimulates fat storage (and no other action), and when it agonizes GLUT4 it stimulates glucose disposal into both muscle and fat tissue (and no other action). These actions always happen at the same time, so it seems it would be easy to associate glucose uptake (into adipose tissue) with fat gain, which is not necessarily the direct cause-and-effect.

This is what I've gathered from the bits and pieces I've picked up; but aren't there are alpha-2 receptors in muscle tissue? Since we don't really store fat in our muscles, this makes me think alpha-2 agonism does more than trigger the "store fat" response.

If any of you guys understand how all of this works, hit me with everything you've got. I realise there may be huge pieces of information I'm missing out on.


-Slim

 

[64Pilot]

Fknknucklhd shoudl be able to answer all of your questions.......From what I have always been told, you most likely eill not store fat as long as u use the slin post-workou tonly

 

[SlimJim300]

I'm not necessarily talking about using slin, just insulin actions in general. I think maybe I need to know specifically more about GLUT4 and it's pathways. Does insulin even agonize GLUT4, or does it just stimulate its release by alpha-2 agonism (or other)?

 

[Makavelli]

I'm not necessarily talking about using slin, just insulin actions in general. I think maybe I need to know specifically more about GLUT4 and it's pathways. Does insulin even agonize GLUT4, or does it just stimulate its release by alpha-2 agonism (or other)?

There are 5 glucose transporters, glut 4 is the one that is most responsible for shuttling glucose into myocytes. I believe that's how it works, but I'm sure someone else can add more or correct me if I'm wrong.