my first bicep injection was 3cc's with a 22guage... I didn't know at the time... let me tell you, I couldn't sleep that night and also had to work at a club... everytime someone brushed against my arm it felt like I was going to rupture the skin on it.
Not too pleasent. Now, I still hit them, I've built up my tolerance to 2cc's, but rarely go over 1... and only use certain things like prop or susp....
C-ditty