Chemistry guys? Dissolve tamoxifen citrate into glycerin?

[THeMaCHinE]

Hey, I was thinking of making my own tamoxifen citrate "home brew" modeled after a popular liquid tamoxifen citrate product.

At the chemistry supply, I've located several styles of glycerin, as well as the tamoxifen citrate powder.

Which style of glycerin? (p.s. end product is for oral use):

#1 Glycerin, 20% Sterile Solution, BiotechGrade (100 ml)

#2 Glycerin, 50% (v/v) Solution, ASTM for Sulfate (500 ml)

#3 Glycerin, 7% (w/v) Solution (500 ml)

Or, would I be better off suspending it in something else? Also, is there any special procedure to blending the powder with the glycerin? Or is it just dump and shake?

Additionally,

What is the difference between tamoxifen and tamoxifen citrate USP in terms of application for bodybuilding? (I know the citrate is what we usually see, just wondering what the other is and why it's more expensive).

 

[Spoud]

Machine,

Tamoxifen is always in the salt form which is tamoxifen citrate. I am not sure whether tamoxifen base powder is available but if it is available, the solubility may be different.

I would go with glycerin 50% w/v + water (1:1 ratio)... Crush the tamoxifen tablet and dump and stir well...

Are you going to sell it???

Remember: glycerin-based products can NOT be used by people that is prone to diabetes.

 

[Zyglamail]

tamoxifin citrate is only "very slightly soluble" in water, acetone, chloroform and in alcohol. Very slightly soluble means you need from 1000 to 10,000 parts solvent per part of solute. It is "soluble" in methanol which means it requires 10-30 parts solvent per part of solute.

 

[Spidey]

tamoxifin citrate is only "very slightly soluble" in water, acetone, chloroform and in alcohol. Very slightly soluble means you need from 1000 to 10,000 parts solvent per part of solute. It is "soluble" in methanol which means it requires 10-30 parts solvent per part of solute.

That isn't advise to use methanol I hope. Methanol is quite toxic. If it isn't very soluble in water than I would go with the highest conc. of glycerine you can find (50%?). Crush up just one tablet and try it out. You may not see everything dissolve as the binders in the tablet may not be soluble.

Good luck

 

[Spoud]

If it is slightly soluble in water, then suspension dosage forms is the best to go

 

[THeMaCHinE]

Machine,

I would go with glycerin 50% w/v + water (1:1 ratio)... Crush the tamoxifen tablet and dump and stir well...

Are you going to sell it???

Actually, I've located it for a decent price in powder form, so no crushing tablets. It appears to be a pretty simple operation of just combining the powder and glycerin, and mixing.

As far as selling it, I hadn't really thought about it. If enough guys were interested, I'd consider it -- for research purposes only of course. I'd want to do more research first to make sure I'm doing it as well as I can, and I'd of course want to research it myself first to make sure it works the way it's supposed to.

Remember: glycerin-based products can NOT be used by people that is prone to diabetes.

Good note. Very important.

 

[THeMaCHinE]

tamoxifin citrate is only "very slightly soluble" in water, acetone, chloroform and in alcohol. Very slightly soluble means you need from 1000 to 10,000 parts solvent per part of solute. It is "soluble" in methanol which means it requires 10-30 parts solvent per part of solute.

So, would it be soluable in ethanol (Golden Grain, etc.) as well? I understand to a point what you are saying, but how would one apply this information in practical terms?

Also, what would be a better carrier for shelf life and sterility -- a 50% glycerin solution or something else?

 

[THeMaCHinE]

This solution is available too... would it be better than any of the above-mentioned?

Glycerin, BioSolv® (1 L)


Also, in the product descriptions,

what does "ASTM for Sulfate (500 ml)" mean?

Also, what are "(w/v)" and "(v/v)"?

 

[THeMaCHinE]

Here is a description for biosolv that I found from a different site:

(polysorbate 80, lecithin, sorbitan monoleate, medium chain triglycerides).

 

[Zyglamail]

That isn't advise to use methanol I hope. Methanol is quite toxic. If it isn't very soluble in water than I would go with the highest conc. of glycerine you can find (50%?). Crush up just one tablet and try it out. You may not see everything dissolve as the binders in the tablet may not be soluble.

Good luck

No its not, I was just quoting USP-25 solubility characteristics of it. Nolva tabs are so god damn cheap I dont understand why anyone would waste their time with suspending powder.