Winny for tendon repair??? (article inside, along with question)

[plornive]

I have some tendon pain my my rear shoulder. I was wondering if anyone has used winny to help tendons to regenerate more quickly. I used winny before and while it caused pain, it certainly didn't cause injury. Here is an article that peaked my interest:

http://www.meso-rx.com/articles/haycock/anabolic-steroids-and-collagen-synthesis.htm

When It Comes to Building Tendons, Not All Steroids are Created Equal
by Bryan Haycock, MS, CSCS

As we approach the new millennium we find the science of building muscle progressing faster than ever before. Long gone are the days of simple trial and error when it comes to building muscle. The modern bodybuilder demands more than just "hear say" if they are to adopt a new training routine or nutritional supplement. This column was created to keep today’s bodybuilder on the cutting edge of scientific research that might benefit them in their quest for body perfection.

Title: Stimulation of collagen synthesis by the anabolic steroid stanozolol.

Researchers: Falanga V, Greenberg AS, Zhou L, Ochoa SM, Roberts AB, Falabella A, Yamaguchi Y; University of Miami School of Medicine, Department of Dermatology, Miami, Veterans Affairs Medical Center, Florida, USA.

Source: J Invest Dermatol 1998 Dec;111(6):1193-7

Summary: In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 micrograms per ml) had no effect on fibroblast replication and cell viability but enhanced collagen synthesis in a dose-dependent manner. Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels. There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta-1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta-1. These findings point to a novel mechanism of action of anabolic steroids.

Discussion: I must first acknowledge that the commonly held belief is that anabolic steroids predispose an athlete to tendon rupture. This conclusion is drawn from animal studies showing that some steroids produce a larger, stiffer tendon in rats and that these steroid-induced tendons "fail" before the tendons from the control animals. The term fail refers to the breaking point.

The interesting thing about the present study is that the steroid stanozolol (Winstrol) had a different effect than testosterone. If you are a regular reader of Meso-Rx you should be well aware that not all steroids act in the same manner. And that because of subtle differences in there molecular structure they are able to elicit different responses. For example, Deca seems to act primarily through the androgen receptor (AR) where as Dianabol has effects beyond those associated with the AR.

Because synthetic steroids have differ in their chemical properties it should not be surprising that testosterone did not have the same effect as Winstrol. Winstrol increased collagen synthesis as opposed to testosterone which did not in this study. Interpreting the results of this study are more difficult than simply describing them. Other researchers have suggested that steroids cause a rapid increase in protein synthesis within tendon fibroblasts which results in fibroids or fibrous nodules within the tendon (Michna,1988). These fibroids alter the mechanical properties of the tendon perhaps predisposing it to rupture. It is also noted that during short term use of steroids there is an alteration in the alignment of collagen fibers which may also lead to rupture. Interestingly these alterations in collagen metabolism are transient with markers of collagen turnover returning more or less to baseline after 3-4 weeks of steroid administration (Karpakka,1992). These same researchers noted that low dose anabolics effect primarily muscle collagenous tissue with tendon being effected only at higher doses (i.e. 5 times the therapeutic dose) which would more closely represent what is needed by bodybuilders to put on mass.

The question remains, dose this mean that Winstrol will actually help prevent tendon injury or will it lead to bigger yet stiffer tendons prone to injury? It is difficult to take animal research and extrapolate the results to humans. Stanozolol is used therapeutically in humans to treat a variety of connective tissue and vascular disorders and its clinical effects suggest that it can modulate connective tissue breakdown in people. Despite being labeled as "ineffective" by many bodybuilders it is very popular among athletes. As with most hormones, dosage plays a role in what effects are seen, be they positive or negative. Hopefully future studies will shed light on the therapeutic effects of different steroids on tendons in humans.

References:

Michna H Appearance and ultrastructure of intranuclear crystalloids in tendon fibroblasts induced by an anabolic steroid hormone in the mouse. Acta Anat (Basel) 1988;133(3):247-50

Karpakka JA, Pesola MK, Takala TE. The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendon. A preliminary report. Am J Sports Med 1992 May-Jun;20(3):262-6

 

[plornive]

^

 

[plornive]

^

 

[Spidey]

very interesting. I have always stayed away from winny because of its reputed "joint-drying" effects (my joints are bad enough as it is). I do have chronic tendon problems however. I may reconsider.

 

[Xizor]

found these studies hope it helps..

Agents Actions 1989 Nov;28(3-4):279-82 Related Articles, Links


The effect of the anabolic steroid, stanozolol, on the production of procollagenase by human synovial and skin fibroblasts in vitro.
Wright JK, Smith AJ, Cawston TE, Hazleman BL.

Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK.

The ability of the anabolic steroid, stanozolol, to stimulate procollagenase production by human synovial and skin fibroblasts was examined in an in vitro assay system. Stanozolol is used therapeutically to treat a variety of connective tissue and vascular disorders and its clinical effects suggest that it can modulate connective tissue breakdown. The results showed that stanozolol was capable, in a dose dependent manner, of significantly stimulating procollagenase production by skin fibroblasts. However, in three synovial fibroblast lines no evidence was found of increased collagenase production following treatment with stanozolol; although the synovial fibroblasts secreted significantly increased amounts of procollagenase in response to IL-1. These results may shed some light on the mechanism of action in vivo of stanozolol in the treatment of connective tissue disorders.

PMID: 2556901 [PubMed - indexed for MEDLINE]
-------------------
Invest Dermatol 1998 Dec;111(6):1193-7 Related Articles, Links


Stimulation of collagen synthesis by the anabolic steroid stanozolol.
Falanga V, Greenberg AS, Zhou L, Ochoa SM, Roberts AB, Falabella A, Yamaguchi Y.

University of Miami School of Medicine, Department of Dermatology, Miami Veterans Affairs Medical Center, Florida, USA.

There is evidence that anabolic steroids, which are derived from testosterone and have markedly less androgenic activity, promote tissue growth and enhance tissue repair; however, the mechanisms involved in their anabolic activities remain unclear. In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 microg per ml) had no effect on fibroblast replication and cell viability (p = 0.764) but enhanced collagen synthesis (p < 0.01) in a dose-dependent manner (r = 0.907). Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels (p < 0.001). There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta1. These findings point to a novel mechanism of action of anabolic steroids.

PMID: 9856839 [PubMed - indexed for MEDLINE]

 

[Xizor]

and this one...

Cut and Paste!


"How to increase collegen synthesis!! (i.e. - strengthen those tendons and ligiments)
originally posted by AnimalMass on competitivemuscle.com

While injecting test increases protein syntesis by roughly 50 times, depending on dose and time, most bodybuilders forget that it will reduce collagen synthesis by more than 50% -- more like 80%, giving you the collagen synthesis rate of a senior citizen. Since collagen makes up tendons, bros are very prone to injury if they continue to lift very heavy, unless they cycle off T and let their collagen synthesis get back to normal. It's like having the skeletal muscle of a gorilla with the tendons of a very old man.

Winstrol increases collagen synthesis. It will give you bigger tendons. However, your body compensates for this by making them more brittle, weaker, and more prone to injury. I can't tell you how many bros work out anaerobically and become injured while on winstrol. Guys who lift in the 1-5 rep range while on winstrol, to baseball players who sprint all out from a stationary position -- winstrol should be the LAST drug they choose. Most of them like winstrol because they don't get the weight gain from it but it is very detrimental to bros who train for any sport anaerobically. Tendons tear easily on it.

Also, the drugs I mention increase collagen syn while also increasing collagen cross-linking integrity, making for a much stronger tendon.

Winstrol, on the other hand, will dramatically increase collagen syn, but ironically it decreases collagen cross-linking integrity, thus making a much weaker tendon.

You can plan a cycle of AAS which will increase collagen synthesis and skeletal muscle growth at the same time. The key is the drug(s) you choose.

Deca, Equipoise, Anavar, and Primobolan will ALL increase skeletal muscle while at the same time dramatically increase collagen syn and bone mass and density, leaving you with a substantially reduced chance of becoming injured than if you choose to use AAS like sus, cyp, or enth.

While testosterone will increase bone mass and density, even at supra-physiological levels, the result is weaker tendons due to inhibition of collagen syn.

To plan a cycle where the goal is to increase skeletal muscle mass/strength while at the same time increase joint/tendon/ligament strength, enough to keep up with the dramatic increase in skeletal muscle, you must choose drugs like Eq, Deca, Anavar, or Primo as the base of your cycle. Testosterone and its esters can be added to your cycle to keep levels within a 'normal' physiological range (ie, 100-200 mg/wk) but must not go above this. Since drugs like eq, deca, anavar and primo will reduce endogenous, natural levels of test, these levels may be maintained with exogenous test in the 100-200 mg/wk range. Test at this dose will not inhibit collagen syn, but paradoxically, will help increase it. It is when exogenous testosterone is used > 200 mg/wk that collagen syn is inhibited.

Deca @ 3 mg/kg a week(about 270 mg/wk for a 200 lb male) will increase procollagen III levels by 270% by week 2. Procollagen III is a primary indicator used to determine the rate of collagen syn. As you can see, deca is a very good drug at giving you everything you want -- an increase in collagen syn, an increase in skeletal muscle, and increases in bone mass and density. The one thing it does not give you is wood

Primobolan, @ 5 mg/kg, will increase collagen synthesis by roughly 180% -- less than deca and equipoise but still substantial.

Equipoise @ 3 mg/kg will increase procollagen III by approximately 340% -- slightly better than deca.

Oxandrolone has over a hundred studies documenting its effectiveness at treating patients needing rapid increases in collagen syn to enhance healing.

These drugs have longer half-lives than most other AAS, so this should be considered when timing your post cycle clomid use. Here they are:

Deca: 15 days Equipoise: 14 days Primobolan: 10.5 days

Anavar has a half-life of only 8 hours so it should not pose a problem.

GH is probably the most remarkable drug at increasing collagen synthesis. It increases collagen syn in a dose dependant manner -- the more you use, the more you will increase collagen syn. It has also demonstrated this ability in short and long term studies. From what I've read, hGH at 6 iu/day increased the collagen deposition rate by around 250% in damaged collagen structures. This result indicates that the increased biomechanical strength of wounds to collagen structures treated with biosynthetic human growth hormone was produced by an increased deposition of collagen in the collagen structures.

Eq, primo, anavar, and deca are all good -- they increase several biomakers of collagen syn -- ie, type III, II, I, procollagen markers. GH just seems to do so most dramatically.

Use of any of these drugs @ supra-physiological levels with a maintenance dose of test will increase collagen syn while at the same time increase skeletal muscle mass. Skeletal muscle mass gains will not be as dramatic as with large testosterone doses but you have to weigh the risk/reward basis for yourself. Also, these drugs do not satisfy the libido like testosterone, but that is not the point of this thread. It is only to demonstrate that you can increase skeletal muscle and collagen syn at the same time with certain AAS -- the decision is up to you.

AnimalMass"

 

[Spidey]

I would give you karma but the karma function seems to be messed up right now. I just get a bunch of computer code in the karma window.

 

[doublebicep]

I would give you karma but the karma function seems to be messed up right now. I just get a bunch of computer code in the karma window.

Yep, I just tried to give you some karma but it looks like a PHP/SQL/Database problem:
===============================
query_first("SELECT userid,usergroupid,karma,joindate,posts,karmaability FROM user WHERE userid='$bbuserinfo[userid]'") ) { // initialize karmic power $karmicpower = 1; // for every certain number of posts, gain a point $postfactor = intval($power[posts] / $pcpower); if ($postfactor < 1) $postfactor = 0; // for every certain number of days registered, gain a point $timepassed = intval((mktime() - $power[joindate]) / 86400); $timefactor = intval($timepassed / $rdpower); // for every certain number of karma points, gain a point $karmicfactor = intval($power[karma] / $kppower); if ($karmicfactor < 1) $karmicfactor = 0; // compute the user's total karmic power $karmicpower = $karmicpower + $postfactor + $timefactor + $karmicfactor; // make negative karma worth half of positive, but at least 1 $karmicnegpower = intval($karmicpower / 2); if ($karmicnegpower < 1) $karmicnegpower =1; // SUCKERS get no Karmic Power if (($power[posts] < $minkarmapost) or ($power[karma] < $minkarmacount) or ($power[usergroupid] ==$karmasuckers) or ($power[karmaability]!=1)) { $karmicpower =0; $karmicnegpower =0; } // ADMINS get loads if ($power[usergroupid] ==6) { $karmicpower =$adminpower; $karmicnegpower =$adminpower; } if($troubleshoot==1) echo "kp=$karmicpower, knp=$karmicnegpower"; // error checking $postcheck=$DB_site->query_first("SELECT userid FROM post WHERE postid='$postid'"); if($postcheck[userid]==$bbuserinfo[userid] or $postcheck[userid]!=$userid) { eval("\$karma_error= \"".gettemplate("karma_off")."\";"); $error=1; } if($repeat=$DB_site->query_first("SELECT postid FROM karma WHERE whoadded='$bbuserinfo[userid]' AND postid = '$postid'")) { eval("\$karma_error= \"".gettemplate("karma_errorsamepost")."\";"); $error=1; // Logician Hack: Give error screen now and here to avoid dublicate karmas: eval("dooutput(\"".gettemplate("karma")."\");");exit; $DB_site->free_result($repeat); unset($repeat); // Logician Hack: Give error screen now and here to avoid dublicate karmas: } if (($error!=1) and ($bbuserinfo[usergroupid]!=6)) { if($maxkarmaperday >= $karmarepeat) $klimit=($maxkarmaperday+1); else $klimit=($karmarepeat+1); $checks=$DB_site->query("SELECT userid,timestamp FROM karma WHERE whoadded='$bbuserinfo[userid]' ORDER BY timestamp DESC LIMIT 0,$klimit"); for($i=0;$check=$DB_site->fetch_array($checks);$i++) { if(($i < $karmarepeat) and ($check[userid]==$userid)) { $error=1; eval("\$karma_error= \"".gettemplate("karma_errorsameuser")."\";"); } if($i==$maxkarmaperday and (($check[timestamp] + 86400) > mktime())) { $error=1; eval("\$karma_error= \"".gettemplate("karma_errortoomany")."\";"); } } $DB_site->free_result($checks); unset($check); } if ($error !=1) { // success-- add karmic record $oldkarma=$DB_site->query_first("SELECT karma FROM user WHERE userid='$userid'"); if($karma=="pos") { $newkarmapos=$karmicpower; $newuserkarma=($oldkarma[karma] + $karmicpower); } else { $newkarmaneg=$karmicnegpower; $newuserkarma=($oldkarma[karma] - $karmicpower); } // Logician Hack: Give error screen now and here to avoid dublicate karmas: if($repeat=$DB_site->query_first("SELECT postid FROM karma WHERE whoadded='$bbuserinfo[userid]' AND postid = '$postid'")) { eval("\$karma_error= \"".gettemplate("karma_errorsamepost")."\";"); $error=1; eval("dooutput(\"".gettemplate("karma")."\");");exit; $DB_site->free_result($repeat); unset($repeat); // Logician Hack: Give error screen now and here to avoid dublicate karmas: } $DB_site->query("UPDATE user SET karma='$newuserkarma' WHERE userid='$userid'"); $DB_site->query("INSERT INTO karma (karmaid,postid,karmapos,karmaneg,userid,whoadded,reason,timestamp) VALUES ('','$postid','$newkarmapos','$newkarmaneg','$userid','$bbuserinfo[userid]','".addslashes(censortext($reason))."','".time()."')"); eval("\$karma_adjust= \"".gettemplate("karma_thanks")."\";"); $DB_site->free_result($oldkarma); $DB_site->free_result($powers); unset($oldkarma); unset($power); } } } } else { // no action set, default to showing the karmic adjustors if ($userid < 1 or $postid <1) { eval("\$karma_error= \"".gettemplate("karma_off")."\";"); eval("dooutput(\"".gettemplate("karma")."\");"); exit; } if ($bbuserinfo[userid]==$userid){ // is this your own post? $current=$DB_site->query_first("SELECT userid,karma FROM user WHERE userid = '$userid'"); $reasons=array(); $ratings=array(); if($postkarmas=$DB_site->query("SELECT karmapos,karmaneg,reason FROM karma WHERE postid='$postid' ORDER BY timestamp DESC")) { for($i=0;$postkarma=$DB_site->fetch_array($postkarmas);$i++) { $totalpos=$totalpos+$postkarma[karmapos]; $totalneg=$totalneg+$postkarma[karmaneg]; if(strlen($postkarma[reason]) > 0) { if ($doneheader!=1) { eval("\$karma_reasonheader = \"".gettemplate("karma_reasonheader")."\";"); eval("\$karma_reasonfooter = \"".gettemplate("karma_reasonfooter")."\";"); $doneheader=1; } if ($postkarma[karmapos]!=0) $reasonrating="images/karmapos.gif"; else $reasonrating="images/karmaneg.gif"; $reason=bbcodeparse($postkarma[reason]); if ($reasonbitbg!="{firstaltcolor}") $reasonbitbg="{firstaltcolor}"; else $reasonbitbg="{secondaltcolor}"; eval("\$karma_reasonbits .= \"".gettemplate("karma_reasonbits")."\";"); } } if ($totalpos > $totalneg) { $karmadif = ($totalpos - $totalneg); $isitnegorpos = "somewhat positive"; if($karmadif > 5) $isitnegorpos = "positive"; if($karmadif > 15) $isitnegorpos = "very positive"; if($karmadif > 25) $isitnegorpos = "extremely positive"; } else if ($totalpos == $totalneg) { $isitnegorpos = "even"; } else { $karmadif = ($totalneg - $totalpos); $isitnegorpos = "somewhat negative"; if($karmadif > 5) $isitnegorpos = "negative"; if($karmadif > 15) $isitnegorpos = "very negative"; if($karmadif > 25) $isitnegorpos = "extremely negative"; } $karmaonthispost= $isitnegorpos; // if this is your post, show the post's karma total } else { $karmaonthispost= "even"; } eval("\$karma_adjust = \"".gettemplate("karma_yourpost")."\";"); $DB_site->free_result($current); unset($current); $DB_site->free_result($postkarmas); unset($postkarma); } else if ($error!=1) { // if this is not your post, then you may adjust the karma // error checking if($repeat=$DB_site->query_first("SELECT postid FROM karma WHERE postid = '$postid' AND whoadded='$bbuserinfo[userid]'")) { eval("\$karma_error= \"".gettemplate("karma_errorsamepost")."\";"); $error=1; $DB_site->free_result($repeat); unset($repeat); } $postcheck=$DB_site->query_first("SELECT post.userid,user.username FROM post LEFT JOIN user ON post.userid=user.userid WHERE postid='$postid'"); if($postcheck[userid]==$bbuserinfo[userid] or $postcheck[userid]!=$userid) { eval("\$karma_error= \"".gettemplate("karma_off")."\";"); $error=1; } $username=$postcheck[username]; if (($error!=1) and ($bbuserinfo[usergroupid]!=6)) { if($maxkarmaperday >= $karmarepeat) $klimit=($maxkarmaperday+1); else $klimit=($karmarepeat+1); $checks=$DB_site->query("SELECT userid,timestamp FROM karma WHERE whoadded='$bbuserinfo[userid]' ORDER BY timestamp DESC LIMIT 0,$klimit"); for($i=0;$check=$DB_site->fetch_array($checks);$i++) { if(($i < $karmarepeat) and ($check[userid]==$userid)) { $error=1; eval("\$karma_error= \"".gettemplate("karma_errorsameuser")."\";"); } if($i==$maxkarmaperday and (($check[timestamp] + 86400) > mktime())) { $error=1; eval("\$karma_error= \"".gettemplate("karma_errortoomany")."\";"); } } $DB_site->free_result($checks); unset($check); } if ($error!=1) eval("\$karma_adjust = \"".gettemplate("karma_adjust")."\";"); } } if($karmahelpfile!="") $karmahelplink="What is Karma?"; eval("dooutput(\"".gettemplate("karma")."\");"); ?>
===================================

I have to give it to you later, but great info, thanks bro!

 

[Spidey]

and this one...

Cut and Paste!


"How to increase collegen synthesis!! (i.e. - strengthen those tendons and ligiments)
originally posted by AnimalMass on competitivemuscle.com

While injecting test increases protein syntesis by roughly 50 times, depending on dose and time, most bodybuilders forget that it will reduce collagen synthesis by more than 50% -- more like 80%, giving you the collagen synthesis rate of a senior citizen. Since collagen makes up tendons, bros are very prone to injury if they continue to lift very heavy, unless they cycle off T and let their collagen synthesis get back to normal. It's like having the skeletal muscle of a gorilla with the tendons of a very old man.

Winstrol increases collagen synthesis. It will give you bigger tendons. However, your body compensates for this by making them more brittle, weaker, and more prone to injury. I can't tell you how many bros work out anaerobically and become injured while on winstrol. Guys who lift in the 1-5 rep range while on winstrol, to baseball players who sprint all out from a stationary position -- winstrol should be the LAST drug they choose. Most of them like winstrol because they don't get the weight gain from it but it is very detrimental to bros who train for any sport anaerobically. Tendons tear easily on it.

Also, the drugs I mention increase collagen syn while also increasing collagen cross-linking integrity, making for a much stronger tendon.

Winstrol, on the other hand, will dramatically increase collagen syn, but ironically it decreases collagen cross-linking integrity, thus making a much weaker tendon.

You can plan a cycle of AAS which will increase collagen synthesis and skeletal muscle growth at the same time. The key is the drug(s) you choose.

Deca, Equipoise, Anavar, and Primobolan will ALL increase skeletal muscle while at the same time dramatically increase collagen syn and bone mass and density, leaving you with a substantially reduced chance of becoming injured than if you choose to use AAS like sus, cyp, or enth.

While testosterone will increase bone mass and density, even at supra-physiological levels, the result is weaker tendons due to inhibition of collagen syn.

To plan a cycle where the goal is to increase skeletal muscle mass/strength while at the same time increase joint/tendon/ligament strength, enough to keep up with the dramatic increase in skeletal muscle, you must choose drugs like Eq, Deca, Anavar, or Primo as the base of your cycle. Testosterone and its esters can be added to your cycle to keep levels within a 'normal' physiological range (ie, 100-200 mg/wk) but must not go above this. Since drugs like eq, deca, anavar and primo will reduce endogenous, natural levels of test, these levels may be maintained with exogenous test in the 100-200 mg/wk range. Test at this dose will not inhibit collagen syn, but paradoxically, will help increase it. It is when exogenous testosterone is used > 200 mg/wk that collagen syn is inhibited.

Deca @ 3 mg/kg a week(about 270 mg/wk for a 200 lb male) will increase procollagen III levels by 270% by week 2. Procollagen III is a primary indicator used to determine the rate of collagen syn. As you can see, deca is a very good drug at giving you everything you want -- an increase in collagen syn, an increase in skeletal muscle, and increases in bone mass and density. The one thing it does not give you is wood

Primobolan, @ 5 mg/kg, will increase collagen synthesis by roughly 180% -- less than deca and equipoise but still substantial.

Equipoise @ 3 mg/kg will increase procollagen III by approximately 340% -- slightly better than deca.

Oxandrolone has over a hundred studies documenting its effectiveness at treating patients needing rapid increases in collagen syn to enhance healing.

These drugs have longer half-lives than most other AAS, so this should be considered when timing your post cycle clomid use. Here they are:

Deca: 15 days Equipoise: 14 days Primobolan: 10.5 days

Anavar has a half-life of only 8 hours so it should not pose a problem.

GH is probably the most remarkable drug at increasing collagen synthesis. It increases collagen syn in a dose dependant manner -- the more you use, the more you will increase collagen syn. It has also demonstrated this ability in short and long term studies. From what I've read, hGH at 6 iu/day increased the collagen deposition rate by around 250% in damaged collagen structures. This result indicates that the increased biomechanical strength of wounds to collagen structures treated with biosynthetic human growth hormone was produced by an increased deposition of collagen in the collagen structures.

Eq, primo, anavar, and deca are all good -- they increase several biomakers of collagen syn -- ie, type III, II, I, procollagen markers. GH just seems to do so most dramatically.

Use of any of these drugs @ supra-physiological levels with a maintenance dose of test will increase collagen syn while at the same time increase skeletal muscle mass. Skeletal muscle mass gains will not be as dramatic as with large testosterone doses but you have to weigh the risk/reward basis for yourself. Also, these drugs do not satisfy the libido like testosterone, but that is not the point of this thread. It is only to demonstrate that you can increase skeletal muscle and collagen syn at the same time with certain AAS -- the decision is up to you.

AnimalMass"

So it actually looks like EQ, primo, anavar or deca are a better choices than winny. Winny seems to make larger but weaker tendons while the others promote bigger, stronger tendons. It kind of makes a good case for staying away from large doses of test I would say.

 

[Spidey]

and this one...


Oxandrolone has over a hundred studies documenting its effectiveness at treating patients needing rapid increases in collagen syn to enhance healing.

I have only turned up one such study in pubmed. Could you point me to some others?