Please Scroll Down to See Forums Below MickyBlues
New member
What are peoples results with Dermacrine or Dermacrine Sust. ? Im looking to get a more hard and vascular look and was wondering how this product is.
Question about Dermacrine?
- Thread starter MickyBlues
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DJ_UFO
Banned
Is Dermacrine Sustain, not sustanon. Sustain is not anabolic like to give u a harder or vascular look, but it will stimulate your body to produce more LH hormone and that means extra natty test. You will feel awesome on it, your mood, your concentration, you'll be happier, more energy. Your balls will be bigger, plump and juicy.
Probably regular Dermacrine is anabolic due to Dhea, but at the same time that could shut you down.
Probably regular Dermacrine is anabolic due to Dhea, but at the same time that could shut you down.
needtogetaas
New member
Dermacrine is a topically applied product that can dramatically increase testosterone, while maintaining a safe balance of estrogen and DHT. Our cutting edge topical formula is the ultimate supplement for any man who wishes to increase energy, lean muscle, reduce fat, and optimize his sexual performance. Dermacrine is a well balanced forumla that supports testosterone without compromising cholesterol levels, prostate or liver health.DJ_UFO said:
By combining hormone precursors and natural anti-estrogens, Dermacrine helps boost testosterone and other important hormones to support muscle growth, fat loss, sexual function and mental performance
Dermacrine is positively correlated to increase lean body mass and reduce fat mass through four main mechanisms: Combating cortisol dominance, increasing GH & IGF-1, increasing androgens, reducing estrogen, and increasing thermogenesis.
Cortisol dominance is an unbalanced hormonal profile that favors cortisol activity through either high cortisol levels, low androgen levels, or both. This hormonal shift towards cortisol dominance can be caused by excessive physical or mental stress [ ↑ cortisol], post steroid use [ ↓ androgen], alcohol consumption [ ↓ androgen ↑ cortisol] and old age [ ↓ androgen ↑ cortisol] 1,2,3,4 In all cases, cortisol dominance is a condition associated with decreased muscle mass, increased fat mass, and degradation of general well being.4,5,17,18,19 Excessive cortisol activity can also decrease production of steroid hormones and androgens creating further cortisol dominance.6 In order to neutralize the negative effects of cortisol and avoid cortisol dominance, one must maintain optimum levels of critical androgens.24 Illustrated on the "Hormones" page
DHEA is an immediate precursor to the critical androgens known as androstenediol and androstenetriol.20,21 These metabolites of DHEA are known to have powerful anti-catabolic and anti-cortisol activity by counteracting the muscle wasting and immuno-suppressive effects of cortisol.23,24 Both androstenediol and androstenetriol act as anabolic hormones and have been shown to enhance recovery and tissue repair from injury.24,25 Furthermore, DHEA, androstenediol and androstenetriol have been found to be potent enhancers of the immune system, by helping to fight off infection, protect against lethal radiation, and restore immunity during times of stress.26-29
Studies using DHEA with elderly subjects and HIV patients have also shown restoration of immune system activity by increasing the division of immune promoting cells.30,31,32 Its been proposed that this increased division of immunogenic cells is a result of DHEA increasing the bioavailability of IGF-1 and enhancing cellular mitosis.31
DHEA's stimulation of IGF-1 activity is supported by other human trials.33,34 These studies have also revealed that DHEA can stimulate GH release. Therefore, the increase in IGF-1 can be explained by the increase in GH, since GH is converted to IGF-1 in the liver. An explanation for the GH release can be explained here by Suarez et al. 2005,
"it can be inferred that DHEA may release GH in vivo by reducing somatotrope responsiveness to somatostatin, as well as by enhancing somatotrope sensitivity to GHRH."
In general terms, DHEA sensitizes the pituitary to GHRH and boosts the release of GH.34
The increase in GH and IGF-1 with DHEA supplementation has shown to have real world benefits in muscle growth, fat loss and muscle strength in various human studies.35,36,37 Besides having a direct effect on body composition, IGF-1 plays an important role in steroidogenic hormone production. Most notably, IGF-1 stimulates the conversion of cholesterol to pregnenolone, otherwise known as the rate limiting step in steroid hormone synthesis. Enhancement of steroidal synthesis by IGF-1 is accomplished by IGF-1's action upon the leydig cell and stimulation of CYP11A, 3b HSD, and StAR. 38,39,40 Direct stimulation upon the leydig cell from IGF-1 helps initiate the first steps in creating anabolic hormones such as androstenedione, androstenediol, and testosterone.
Unlike anabolic androgenic steroids, which can dramatically inhibit the bodies hormone production,9-12, and degrade the enzymes responsible for testosterone synthesis, such as the 17a-hydroxylase enzyme, 3b HSD, and cAMP.13,76-79 DHEA and pregnenolone appear to encourage there own production by stimulating the enzymes and hypothalamus to increase androgen production. Pregnenolone has been found to increase the release of gonadotropin releasing hormone (GnRH) from the pituitary, and thereby increase luteinizing hormone (LH) and follicle stimulating hormone (FSH) release.7 DHEA has been shown to stimulate StAR at a cellular level, therefore enhancing uptake of cholesterol into the mitochondria and up-regulating the rate limiting step in hormone synthesis.8 These properties of DHEA and pregnenolone make them an excellent choice for men wishing to boost hormone levels without having an overly suppressive effect on the body. Still, DHEA and pregnenolone can eventually convert to estrogen through interaction with the aromatase enzyme (CYP 19). Excessive estrogen can inhibit the hypothalamus pituitary testicular axis (HTPA), and increase fat deposits and water retention41. Fortunately, Dermacrine limits estrogen synthesis by including the Phyto Aromatase Inhibitor (Phyto AI) complex, consisting of three potent plant based aromatase inhibitors, namely 7,8 benzoflavone, chrysin and resveratrol.42,43 These flavonoids directly compete with aromatizing androgens for interaction with the aromatase enzyme as well as inhibit the production of the aromatase enzyme itself.44,45 As a result, estrogen is kept down , and the steroidogenic enzymes are kept up, therefore making Dermcrine one complete hormone rejuvenator.
Aside from reducing estrogen and estrogen related fat depositing. The fat loss is further catalyzed by the ingredients DHEA and 7-keto DHEA. Both of these powerful thermogenic hormones increase calorie burning and fat loss by directly activating the mitochondrial and cytosolic thermogenic enzymes in liver.46,47.
Numerous studies with animals and humans have shown dramatic increases in fat and weight loss with the use of DHEA and 7-keto DHEA.48,49,50,51 Since DHEA is not a stimulant, the fat loss is accomplished without the jitters, anxiety or heart palpitations associated with drugs like caffeine and ephedra.
In summery, Dermacrine may help improve body composition by antagonizing cortisol, stimulating GH & IGF-1 release, raising anabolic/androgenic hormones, reducing estrogens and eliciting a thermogenic response from liver enzymes.
and no it will not shut you down unless used for a long time. 4-6 weeks is as long as I would use this...
pm me for discounts.
DJ_UFO said:
Haha! You said plump and juicy! LOL
newbro said:
Dermacrine would be a perfect stack with Anavar. It would give you a very nice boost of natural androgens (Adione, Adiol, Atriol, ect) which will help with strength, recovery, sex drive, ect. Dermacrine could easily replace the need for Test on a cycle like this.
If you guys are looking for something to use off cycle then Sustain is probably what you want. Dermacrine is great as a standalone supplement, but you have to be careful not to use it for too long as it can eventually shut you down. (not good if your already on AAS for most of the year)
If you’re not using steroids then Dermacrine would be a good legal alternative, and it stacks well with other pro-hormones (superdrol, halodrol, ect) so you can make a pretty effective cycle out of this which would be totally legal. Just keep the cycle under 6 weeks and get Sustain for PCT an you will recovery just fine.
-Pp
