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Does anyone know the "real" half life of Testosterone Enanthate?
- Thread starter OXANDRIN
- Start date
Juiced2theGills
New member
Hope this helps:
Since it is effective for such a long period of time, Testosterone enanthate is always taken more frequently by athletes during their "steroid intervals." An injection of 250 mg every 2-3 weeks helps maintain strength and mass.
Since it is effective for such a long period of time, Testosterone enanthate is always taken more frequently by athletes during their "steroid intervals." An injection of 250 mg every 2-3 weeks helps maintain strength and mass.
milo hobgoblin
New member
Well...
I would have to say 7 to 8 days. I used my sex drive as a determinant.
Im thinking enanthate is the longest acting test in Sustanon 250 and after 8 days... my sex drive was gone. (Thanks to the fina completely shuttting me down)
Whatever sex drive I had was completely driven by the sustanon so... at almost exactly 8 days... nada.
I would have to say 7 to 8 days. I used my sex drive as a determinant.
Im thinking enanthate is the longest acting test in Sustanon 250 and after 8 days... my sex drive was gone. (Thanks to the fina completely shuttting me down)
Whatever sex drive I had was completely driven by the sustanon so... at almost exactly 8 days... nada.
Texas Ranger
New member
Milo, there's absolutely NO Test Enanthate in Sustanon/Omnadren.
milo hobgoblin
New member
...
k... is it prop/cyp/dec and undec then? could of swore I thought Enan was in there.
k... is it prop/cyp/dec and undec then? could of swore I thought Enan was in there.
_Yossarian_
New member
decanoate is the longest ester in sust. I believe eod injections are needed to get the most stable blood levels with enanthate. There's a thread floating around in the archives discussing this, I cant remember the author, jubei maybe???
psychedout
New member
5 days.
psychedout
New member
It depends on how you look at it. If you count half-life from the day you inject (which I do) then enathates half life is 5 days, as it has to 50% of the ammount originally in the bloodstream.
zziggzzigg
New member
It does not seem possible that testosterone blood levels are at their highest 24 hours after cypionate injection as the chart illustrates.
a week or so
gunner44
New member
zziggzzigg said:
It does seem wierd, but we have all seen that chart.
What that tells me is that there is a certain amount of absorbtion rate that takes place at the site of the injection, as well as the steroid making its way into the blood stream where the ester is removed.
I think that the ester must be removed quite quickly as it is absorbed into the muscle tissue surrounding the injection bolus.
I sure wish someone could explain this in more detail, cuz I have always wondered about that.
Anybody??
1: Int J Androl 1984 Jun;7(3):181-7 Related Articles, Books
Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivary testosterone levels in normal men.
Schurmeyer T, Nieschlag E.
The pharmacokinetics of 2 testosterone esters, testosterone enanthate and testosterone cyclohexanecarboxylate, were compared in a single blind crossover study in healthy young men. Their effects on serum and salivary levels of testosterone, as well as on the serum levels of LH, FSH and prolactin were measured after the injection of doses equivalent to 140 mg free testosterone. Both preparations yielded supraphysiological testosterone levels in serum and saliva as early as 2 h following injection, reaching peak levels 4 to 5 times above basal between 8 and 24 h. LH and FSH levels were suppressed as long as serum testosterone levels were elevated. Nine days after injecting testosterone enanthate and 7 days after giving testosterone cyclohexanecarboxylate, serum and salivary levels of testosterone had returned to basal. The longer activity of testosterone enanthate was also evidenced from more extended suppression of gonadotrophin levels. Although neither preparation is ideal because of the initial supraphysiological peaks, testosterone enanthate appears preferable for clinical use because of its slightly longer duration of action.
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Nine days after injection of Enanthate serum level returned to normal, which gives us 4.5 days of half life.
Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivary testosterone levels in normal men.
Schurmeyer T, Nieschlag E.
The pharmacokinetics of 2 testosterone esters, testosterone enanthate and testosterone cyclohexanecarboxylate, were compared in a single blind crossover study in healthy young men. Their effects on serum and salivary levels of testosterone, as well as on the serum levels of LH, FSH and prolactin were measured after the injection of doses equivalent to 140 mg free testosterone. Both preparations yielded supraphysiological testosterone levels in serum and saliva as early as 2 h following injection, reaching peak levels 4 to 5 times above basal between 8 and 24 h. LH and FSH levels were suppressed as long as serum testosterone levels were elevated. Nine days after injecting testosterone enanthate and 7 days after giving testosterone cyclohexanecarboxylate, serum and salivary levels of testosterone had returned to basal. The longer activity of testosterone enanthate was also evidenced from more extended suppression of gonadotrophin levels. Although neither preparation is ideal because of the initial supraphysiological peaks, testosterone enanthate appears preferable for clinical use because of its slightly longer duration of action.
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Nine days after injection of Enanthate serum level returned to normal, which gives us 4.5 days of half life.
OXANDRIN
New member
panerai,
i read that as well. my only thought was 140mg mg of free testosterone will equal more than 140mg of T-Enanthate because of the weight of the ester. my guess would be 150-170mg of TE = 140mg of unesterified Testosterone
in this case what is baseline?
150mg with a 5 day half life would be 75mg and at 9 days would be 37.5 (day 10 actually)
what does this mean?
if basline is 37.5 then TE has a half life of 5 days
just say baseline is 35
35 x 4 = 140mg (4-5 times baseline was shown)
35 x 5 = 175mg (4-5 times baseline was shown)
i am rounding up. i agree with you that the half life is close to 4.5 days.
now 250mg of TE would not get to a baseline of 35-40mg for a while
1: 250mg
5: 175mg
10: 87.5
15: 43.75
i read that as well. my only thought was 140mg mg of free testosterone will equal more than 140mg of T-Enanthate because of the weight of the ester. my guess would be 150-170mg of TE = 140mg of unesterified Testosterone
in this case what is baseline?
150mg with a 5 day half life would be 75mg and at 9 days would be 37.5 (day 10 actually)
what does this mean?
if basline is 37.5 then TE has a half life of 5 days
just say baseline is 35
35 x 4 = 140mg (4-5 times baseline was shown)
35 x 5 = 175mg (4-5 times baseline was shown)
i am rounding up. i agree with you that the half life is close to 4.5 days.
now 250mg of TE would not get to a baseline of 35-40mg for a while
1: 250mg
5: 175mg
10: 87.5
15: 43.75
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zziggzzigg
New member
quote: Originally posted by OXANDRIN
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200mg would look like this
200mg Day 1
100mg Day 5
50mg Day 10
25mg Day 15
12.5mg Day 20
6.25mg Day 25
3.125mg Day 30
===========================================
if it is perfectly linear, the above chart is what the depot in your glute would look like, but does not necessarily show us what blood serum levels would be doing over that time period, as there would be different metabolic action on the testosterone once released from the ester depot in the muscle to the bloodstream, from 5ar reduction to aromatase, to shbg, etc.
If you could somehow stop all metabolism of the drug in the bloodstream (impossible of course), you would then have 196.875 mg testosterone floating around in the blood after 30 days... of course this is not what happens but just illustrates to the extreme what I mean by the metabolism issue that needs to be considered and makes the half-life concept a little more complex.
--------------------------------------------------------------------------------
200mg would look like this
200mg Day 1
100mg Day 5
50mg Day 10
25mg Day 15
12.5mg Day 20
6.25mg Day 25
3.125mg Day 30
===========================================
if it is perfectly linear, the above chart is what the depot in your glute would look like, but does not necessarily show us what blood serum levels would be doing over that time period, as there would be different metabolic action on the testosterone once released from the ester depot in the muscle to the bloodstream, from 5ar reduction to aromatase, to shbg, etc.
If you could somehow stop all metabolism of the drug in the bloodstream (impossible of course), you would then have 196.875 mg testosterone floating around in the blood after 30 days... of course this is not what happens but just illustrates to the extreme what I mean by the metabolism issue that needs to be considered and makes the half-life concept a little more complex.
OXANDRIN
New member
does esterified testosterone have the same effect as time release gh.
in the example of nutropin gh the body is constantly exposed to gh release vs regular gh where the substance only lasts several minutes. the continious release of the nutropin (at a smaller dose) is more effective than mutiple daily injects of regular gh at a higher dose.
my thinking here is that while the body only produces 4-7mg of testosterone per day. having 180mg (250mg enanthate) in the system exposes the body to constantly higher testosterone levels.
does this make any sense?
in the example of nutropin gh the body is constantly exposed to gh release vs regular gh where the substance only lasts several minutes. the continious release of the nutropin (at a smaller dose) is more effective than mutiple daily injects of regular gh at a higher dose.
my thinking here is that while the body only produces 4-7mg of testosterone per day. having 180mg (250mg enanthate) in the system exposes the body to constantly higher testosterone levels.
does this make any sense?
zziggzzigg
New member
OXANDRIN
New member
what would baseline testosteone be for a male?
i mean the normal range is between 300-800 ng/dl
5.6 liters of blood in a male (average) = 56 deciliters
1mg = 1,000,000 ng
180mg free test = (250mg of enanthate) = 180,000,000 ng
180,000,000 / 56 = 321 428.571 doesn't make sense.
i mean the normal range is between 300-800 ng/dl
5.6 liters of blood in a male (average) = 56 deciliters
1mg = 1,000,000 ng
180mg free test = (250mg of enanthate) = 180,000,000 ng
180,000,000 / 56 = 321 428.571 doesn't make sense.
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