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A recent thread on tren got me to thinking about ED vs EOD dosing and what the implications of each would be. The argument was that A) tren does not "build up" in your system for 2-3 weeks...as opposed to B) because tren has a short half life (~48hrs) the concentration levels in your system would "build up" and stabilize quickly.
So I decided to do a little research and analysis to see what's going on. I examined dosing ED vs EOD and built an Excel workbook to calculate and track the system concentration taking into account the half life decay. I assumed a half life of 48 hours for simplicity...I'm not saying 48 hours is the actual half life of tren, but I needed to pick a number for the model.
With either ED or EOD dosing, system concentrations buildup and stabilize in about 10 days. So the 2-3 week build up theory has been proven false
Even though the average dose per day would be the same if you were doing 50mg ED or 100mg EOD, the system levels and ranges are interestingly different:
Dosing 100mg EOD results in system levels maxing out at ~200mg with an interdose range of ~100mg. So immediately after your dose on day 10, your system level is up to ~200mg, but immediately prior to your dose on day 12, your system level has fallen to ~100mg...soon to be jacked back up to ~200mg after dosing.
Dosing 50mg ED results in system levels maxing out at 170mg with an interdose range of ~50mg. So immediately after your dose on day 10, your system level is up to ~170mg, but immediately prior to your dose on day 11, your system level has fallen to ~120mg...soon to be jacked back up to ~170 after dosing.
What this shows is that dosing EOD results in higher max system levels and lower min system levels as compared to a comparable ED dose, with your levels fluctuating more widely between doses. In the end it might not make a difference, but everyone has an opinion about which (ED or EOD) is better). My conclusion is that it is really a matter of how larger fluctuations in system level impact results. Obviously, the more often you dose, the more consisten you keep system levels...BUT this is at the expense of maximum system levels. Max levels differed by ~30mg in the above example. If we consider 75mg ED vs 150mg EOD, max system levels differ by ~45mg.
Some people claim better results after changing to ED doses (EX going from 150EOD to 75ED). This suggests that more consistent system levels are more important that max average system level..because by making this change, you would have decreased your average system level by ~45mg, but stay within a tighter range.
Just for reference, you can calculate the amount of a dose remaining in your system with the following equation:
N2 = N1(.05^#half lives)
where:
N2 = amount remaining
N1 = dose amount
#half lives = # of half lives that have elapsed
So a dose amount of 100mg would be down to 70.7107mg after 1 day (.5 half lives) and 50mg after 2 days (1 half life)
Here's a link to a nice half life calculator...it's really for radioisotopes, but the calculations work exactly the same.
http://www.ausetute.com.au/halflife.html
I've also made some graphics to display the system build up and fluctuation with 50mg ED and 100mg EOD:
Although this little analysis is specific to tren, the same basic concepts hold true for other compounds. I'd be interested to look at other compounds with longer half lives and different dosing schedules. Let me know if anyone is interested.
JoBu
So I decided to do a little research and analysis to see what's going on. I examined dosing ED vs EOD and built an Excel workbook to calculate and track the system concentration taking into account the half life decay. I assumed a half life of 48 hours for simplicity...I'm not saying 48 hours is the actual half life of tren, but I needed to pick a number for the model.
With either ED or EOD dosing, system concentrations buildup and stabilize in about 10 days. So the 2-3 week build up theory has been proven false
Even though the average dose per day would be the same if you were doing 50mg ED or 100mg EOD, the system levels and ranges are interestingly different:Dosing 100mg EOD results in system levels maxing out at ~200mg with an interdose range of ~100mg. So immediately after your dose on day 10, your system level is up to ~200mg, but immediately prior to your dose on day 12, your system level has fallen to ~100mg...soon to be jacked back up to ~200mg after dosing.
Dosing 50mg ED results in system levels maxing out at 170mg with an interdose range of ~50mg. So immediately after your dose on day 10, your system level is up to ~170mg, but immediately prior to your dose on day 11, your system level has fallen to ~120mg...soon to be jacked back up to ~170 after dosing.
What this shows is that dosing EOD results in higher max system levels and lower min system levels as compared to a comparable ED dose, with your levels fluctuating more widely between doses. In the end it might not make a difference, but everyone has an opinion about which (ED or EOD) is better). My conclusion is that it is really a matter of how larger fluctuations in system level impact results. Obviously, the more often you dose, the more consisten you keep system levels...BUT this is at the expense of maximum system levels. Max levels differed by ~30mg in the above example. If we consider 75mg ED vs 150mg EOD, max system levels differ by ~45mg.
Some people claim better results after changing to ED doses (EX going from 150EOD to 75ED). This suggests that more consistent system levels are more important that max average system level..because by making this change, you would have decreased your average system level by ~45mg, but stay within a tighter range.
Just for reference, you can calculate the amount of a dose remaining in your system with the following equation:
N2 = N1(.05^#half lives)
where:
N2 = amount remaining
N1 = dose amount
#half lives = # of half lives that have elapsed
So a dose amount of 100mg would be down to 70.7107mg after 1 day (.5 half lives) and 50mg after 2 days (1 half life)
Here's a link to a nice half life calculator...it's really for radioisotopes, but the calculations work exactly the same.
http://www.ausetute.com.au/halflife.html
I've also made some graphics to display the system build up and fluctuation with 50mg ED and 100mg EOD:
Although this little analysis is specific to tren, the same basic concepts hold true for other compounds. I'd be interested to look at other compounds with longer half lives and different dosing schedules. Let me know if anyone is interested.
JoBu
