initial feedback from this thread:
swordfish151 said:
One week into using it, 2 pumps am/pm on the inner forearm...no bloat in sight..im consuming alot more cals then before (was dieting before i got on), im on sustanon (500mgs wk for 12 weeks and 30mgs of dbol for 4 weeks) so far im loving it..dry as hell...pounding down around 3000+ cals....oh and i love the smell...citrus(orange) right..lol
ChefWide said:
smell is good, water down, no sides that i can pinpoint other than the desireable ones... did develop a rash in the crook of each elbow, small blisters actuall, but that might have been from some dastardly combo of events, so i am being very careful to avoid application in that spot for no other reason that the tiny remnants of rash are sore... no skin irritation of any kind anywhere along the inner forearm, so i am guessing external elements NOT realated to the product.
will keep ya informed.
axe3 said:
I luv the smell...wife thinks it smells like bathroom cleaner. I substituted my a-dex for your product. I have been doing 2 squirts 2x per day. I am still dry as all can be. So I have to give it 2 thumbs up.
Ulter said:
Personally, I have been cycling for 20 years and since I started using it, have never been this dry on 800mg/wk of steroids.
some studies:
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Cancer Res. 1982 Aug;42(8 Suppl):3327s-3333s.
A new hypothesis based on suicide substrate inhibitor studies for the mechanism of action of aromatase.
Covey DF, Hood WF.
Recently, it was discovered that 4-hydroxy-4-androstene-3,17-dione, 4-androstene-3,6,17-trione, and 1,4,6-androstatriene-3,17-dione, compounds previously reported to be competitive inhibitors of aromatase, cause a time-dependent loss of aromatase activity in human placental microsomes. We report here that 1,4-androstadiene 3,17-dione (Ki 0.32 microM; kinact 0.91 X 10(-3)/sec) and testolactone (Ki 35 microM; kinact 0.36 X 10(-3)/sec) also cause a similar loss of aromatase activity.
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Physiol Behav. 1987;39(1):141-5.
The aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), blocks testosterone-induced olfactory behaviour in the hamster.
Steel E, Hutchison JB.
The effect of ATD on olfactory investigation in intact and in castrated, testosterone-treated male hamsters was studied using subcutaneous silastic implants. In intact males, there was a dose-dependent action of ATD in reducing sniffing towards novel females and in eliminating the discrimination between females after pre-exposure to vaginal odour. Both sniffing and olfactory discrimination reappeared after removal of ATD implants. Neither the weight nor the general behavioural activity of treated males was affected, indicating a specific behavioural affect. Testosterone (T) maintained olfactory behaviour in castrated males. Untreated castrates and castrates with ATD + T implants showed reduced sniffing and showed no discrimination between females after exposure to female odour. We conclude that conversion of T to oestrogen plays an essential role in the control of male olfactory behaviour.
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this one is quite amusing...
1: Brain Res Dev Brain Res. 1995 Apr 18;85(2):273-9. Related Articles, Links
Increased number of vasopressin neurons in the suprachiasmatic nucleus (SCN) of 'bisexual' adult male rats following perinatal treatment with the aromatase blocker ATD.
Swaab DF, Slob AK, Houtsmuller EJ, Brand T, Zhou JN.
Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam.
In an earlier article an enlarged subpopulation of vasopressin containing neurons was found in the suprachiasmatic nucleus (SCN) of homosexual men as compared to heterosexuals. The present study investigates the possibility that the number of vasopressin neurons in the SCN and sexual partner preference behavior in male rats are both influenced by sex hormones during brain development. For this purpose, we studied groups of adult male rats that had been treated either prenatally or pre- and postnatally with the aromatase inhibitor ATD (1,4,6-androstatriene-3,17-dione) which blocks the aromatization of testosterone to estradiol. Rats treated with ATD in both pre- and postnatal periods showed 'bisexual' partner preference behavior and appeared to have 59% more vasopressin-expressing neurons in the SCN than the controls. The prenatally treated rats did not differ from the controls. This observation supports the hypothesis that the increased number of vasopressin neurons found earlier in the SCN of adult homosexual men might reflect differences that took place in the interaction between sex hormones and the brain early in development
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because the most "interesting" area in animals is sexual differentiation, much of the research is done using silastic capsules which release ATD directly into the brain (great for studying very specific effects of aromatase deprivation on the brain.... but not of too much value in this discussion other than to establish that it is a potent aromatase inhibitor). however feel free to do a search on pubmed for ATD or 1,4,6-androstatriene-3,17-dione. there are nearly 100 studies.
as a note- letro, aromasin and dex are all effective AI's each with their owns quirks and individual variances in response. The purpose of this was to introduce another option, an option that was one not solely limited to Aromatase inhibition and that was OTC.
though by all means wait for additional feedback, you can be sure that it will be similar to that above.
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to suggest that AF would encourage people to take something that was less than effective....
