Dbol & Grapefruit Juice- Does This REALLY Work???

So we need to intake grapefruit every day, but the real question is how much

Watch yourself with it. Again, the enzyme limiting effect lasts up to 24 hours. This can mean an overacumulation of the drug.

Many Many threads on this bros...

From what I remember GFJ helps with the uptake of MANY oral medications as it reduces some liver enzymes that would otherwise break down the medication...

jh1 said:

Many Many threads on this bros...

From what I remember GFJ helps with the uptake of MANY oral medications as it reduces some liver enzymes that would otherwise break down the medication...

Click to expand...

say some one is rocking 25 mg of d bol ED how GF juice would u recomend one drink
'




thanks

damn, gotta love that GFJ! this was a helpful thread... good job ranger

scientific evidence:

Eur J Clin Nutr. 2004 Jan;58(1):1-9. Related Articles, Links


Food-drug interaction: grapefruit juice augments drug bioavailability--mechanism, extent and relevance.

Dahan A, Altman H.

Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.

More than a decade has passed since it was unintentionally discovered that grapefruit juice interacts with certain drugs. The coadministration of these drugs with grapefruit juice can markedly elevate drug bioavailability, and can alter pharmacokinetic and pharmacodynamic parameters of the drug. The predominant mechanism for this interaction is the inhibition of cytochrome P-450 3A4 in the small intestine, resulting in a significant reduction of drug presystemic metabolism. An additional mechanism is, presumably, the inhibition of P-glycoprotein, a transporter that carries drug from the enterocyte back to the gut lumen, resulting in a further increase in the fraction of drug absorbed. Some calcium channel antagonists, benzodiazepines, HMG-CoA reductase inhibitors and cyclosporine are the most affected drugs. A single exposure to one glass of the juice can usually produce the maximal magnitude of the interaction. The data available so far, concerning this interaction and its clinical implications, are reviewed in this article. It is likely that more information regarding this interaction will accumulate in the future, and awareness of such is necessary for achieving optimal drug therapy.

PMID: 14679360 [PubMed - in process]

: Steroids. 1995 Apr;60(4):353-66. Related Articles, Links


Metabolism of anabolic steroids in humans: synthesis of 6 beta-hydroxy metabolites of 4-chloro-1,2-dehydro-17 alpha-methyltestosterone, fluoxymesterone, and metandienone.

Schanzer W, Horning S, Donike M.

Institut fur Biochemie, Deutschen Sporthochschule Koln, Germany.

Hydroxylation at position 6 beta testosterone I (17 beta-hydroxyandrost-4-en-3-one) and the anabolic steroids 17 alpha-methyltestosterone II (17 beta-hydroxy-17 alpha-methylandrost-4-en-3-one), metandienone III (17 beta-hydroxy-17 alpha-methylandrosta-1,4-dien-3-one), 4-chloro-1,2-dehydro-17 alpha-methyltestosterone IV (4-chloro-17 beta-hydroxy-17 alpha-methylandrosta-1,4-dien-3-one), and fluoxymesterone V (9-fluoro-11 beta, 17 beta-dihydroxy-17 alpha-methylandrost-4-en-3-one) was achieved via light-induced autooxidation of the corresponding trimethysilyl 3,5-dienol ethers dissolved in isopropanol or ethanol. The reaction further yielded the 6 alpha-hydroxy isomer in low amounts. The 6 beta-hydroxy isomer of I-V and the 6 alpha-hydroxy isomers of I, III, and IV were isolated and characterized by 1H and 13C NMR, high-performance liquid chromatography, gas chromatography, and mass spectrometry. Human excretion studies with single administered doses of boldenone (17 beta-hydroxyandrosta-1,4-dien-3-one), 4-chloro-1,2-dehydro-17 alpha-methyltestosterone, fluoxymesterone, metandienone, 17 alpha-methyltestosterone, and [16,16,17-2H3] testosterone showed that 6 beta-hydroxylation is the major metabolic pathway in the metabolism of 4-chloro-1,2-dehydro-17 alpha-methyltestosterone, fluoxymesterone, and metandienone, whereas for boldenone, 17 alpha-methyltestosterone, and testosterone, 6 beta-hydroxylation is negligible.

PMID: 8539789 [PubMed - indexed for MEDLINE]

For the dutchies there is an interesting article over here:

http://www.ergogenics.org/grapefruit.html

i use Xanax from time to time and i GUARANTEE that grapefruit juice enhances its effects. in fact, there's a warning on the prescription bottle regarding this. i wouldn't take it without it.


Nadr

So why wouldn't you want to use grapefruit juice with your juice. You get more bang for your buck then right?

Scaggs