Here's some info for you...
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Proviron (Mesterolone) 25mg tabs
Manufacturer/Distributor: Schering
Mechanism:
Oral androgen treatment, balances a deficiency of androgen formation which begins to fall gradually with an increasing age.
Suitable for all conditions caused by a deficient endogenous androgen formation.
In the recommended therapeutic dose, it will not impair spermatogenesis
Well tolerated by the liver.
Indications:
Declining physical activity and mental alertness in middle and old aged men attributeed to androgen deficiency.
Potency disturbances due to androgen deficiency.
Hypogonadism.
Male infertility.
Main Use:
Potency disturbances. Proviron overcomes potency disturbances due to androgen deficiency.It may also be of use as supplementary therapy in cases of diminished potency where androgen deficiency is not the primary cause.
Hypogonadism. Growth, development and function of androgen dependant target organs are stimulated by Proviron.It promotes development of secondary male sex characteristics in cases of prepuberal hypogonadism.Full clinical and laboratory investigations are necessary in all cases of young patients prior to commencement of treatment.Proviron tablets may also be used as a substitute therapy in cases where a loss of gonadal function has occured post-puberally.
Infertility. Oligozoospermia and deficient Leydig cell secretion may be the cause of infertility.With Proviron treatment, sperm count can be increased, the quality improved and further more, a higher fructose concentrations up to normal values can be achieved thus increasing the chances of procreation.
Notes:
If not otherwise directed by a physician, the following dosage is recommended:in declining physical activity and potency disturbances: Commencement treatment: One 25mg tablet 3 times a day. Continuation of treatment:One 25mg tablet 1 - 2 times a day.
According to type and severity of complaints, a course of Proviron lasting 4 - 6 weeks or a prolonged uninterupted treatment of several months is recommended.If required, the course of treatment may be repeated several times.
Hypogonadism requires continous therapy: For development of secondary male characteristics one Proviron 25mg tablet 3 - 4 times daily for several months. As maintenance dose one Proviron tablet of 25mg 2 - 3 times daily will be sufficient.
In oligospermia, one Proviron tablet of 25mg 2 - 3 times a day for the cycle of spermatogenesis ie. 90 days. In cases of simultaneously impaired gonadotrophic excretion, a combined therapy with gonadotrophic hormone exhibiting FSH activity is recommended for the commencement of treatment (eg.2000 IU serum gonadotrophin I/M twice weekly up to a total of 12000 IU).If necessary Proviron treatment is to be repeated after an interval of several days
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"I'n my opinion, it is the most misunderstood bodybuilding drug. Some say it's worthless, some say its useful. I would like to get imput from all, especially those who've used it, in my effort to learn more about this drug. Here is what we do know:
1. IT is an androgenic steroid.
2. It is used as an aromataze inhibitor to reduce estrogen and prevent Gyno and water retention.
3. It doesn't increase test production.
4. It can inhibit natural test production since it is an androgen.
5. It can increase sperm count.
6. It is non toxic.
7. It has a high affinity for Sex Hormone Binding Globulin.
8. It is acted opon by 3betahydroxysteroid dehydrogenase, which inactivates it in muscle tissue, which means it won't lessen gains when used during a cycle, contrary to many beliefs.
9. It dramatically increases muscle hardness.
Now here is what is believed, but not proven.
1. The same enzyme that acts on Proviron is also the same one that inactivates DHT in muscle tissue, therefore, Proviron may act in a DHT like manner to reduce estrogen, thus the increased muscle hardness.
2. It has recently been said on this board and in Anabolics 2000, that since Proviron has a high affinity for SHBG, that when used in conjuction with Test during a cycle, it will increase free test levels.
I was also interested in it's ability to bind to SHBG, so I spoke to Bill Roberts about it. He said: "SHBG doesn't eliminate the steroid, but acts as a depot and a means of transporting them. It doesn't affect free concentrations." In other words, he sees it as useless for this application. "
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".(Daniel Duchaine Underground Steroid Handbook 2: "I can think of no legitimate use for Proviron in enhancing athletic performauce.") Most, however do not know the main use of Proviron in bodybuilding.
You should be aware that Proviron is also an estrogen antagonist which prevents the aromatization of steroids. Unlike the antiestrogen Nolvadex which only blocks the estrogen receptors (see Nolvadex) Proviron already prevents the aromatizing of steroids. Therefore gynecomastia and increased water retention are successfully blocked. Since Proviron strongly suppresses the forming of estrogens no rebound effect occurs after discontinuation of use of the compound as is the case with, for example, Nolvadex where an aromatization of the steroids is not prevented. One can say that Nolvadex cures the problem of aromatization at its root while Nolvadex simply cures the symptoms. For this reason male athletes should prefer Proviron to Nolvadex. With Proviron the athlete obtains more muscle hardness since the androgen level is increased and the estrogen concentration remains low. This, in particular, is noted positively during the preparation for a competition when used in combination with a diet. Female athletes who naturally have a higher estrogen level often supplement their steroid intake with Proviron resulting in an increased muscle hardness. In the past it was common for bodybuilders to take a daily dose of one 25 mg tablet over several weeks, sometimes even months, in order to appear hard all year round. This was especially important for athletes' appearances at guest performances, seminars and photo sessions. Today Clenbuterol is usually taken over the entire year since possible virilization symptoms cannot occur which is not yet the case with Proviron. Since Proviron is very effective male athletes usually need only 50 mg/day which means that the athlete usually takes one 25 mg tablet in the morning and another 25 mg tablet in the evening. In some cases one 25 mg tablet per day is sufficient. When combining Proviron with Nolvadex (50 mg Proviron/day and 20 mg Nolvadex/day) this will lead to an almost complete suppression of estrogen."