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Some time ago Fonz put up an interesting post (on elite I believe) regarding bromocriptine.
As most of us know, GHB and its equivalents have been shown to cause a dramatic increase in growth hormone, which we like very very much. Unfortunately, this has been associated (and at least partially offset) by a significant increase in prolactin. [See the excerpt at the bottom of this post]
The point of Fonz's post was that bromocriptine destroys prolactin. In addition, as shown in the study below, people who took bromocriptine by itself over 18 weeks lost an average of about 10 lbs. more than the people in the group receiving a placebo.
In sum, it appears that a combination of GHB and bromocriptine would result in elevated GH without a concurrent increase in prolactin. This would be a very potent fat burning combination which could be anabolic and anti catabolic as well.
Bromocriptine is available (apparently without a prescription) at http://208.234.10.47/mcart/?task=item&ItemID=IT11
Has anybody tried this, or does anybody know more about the subject?
Here is an interesting read on the fat reducing effects of bromocriptine alone, excerpted from
http://www.ispub.com/journals/IJAPA/Vol1N2/obesity2.html
Bromocriptine
Bromocriptine is a dopamine agonist the has been shown to decrease body fat stores in experimental animals with little or no reduction in body weight or food intake.145 Accordingly, Meier and colleagues treated 33 obese postmenopausal women and 15 men with poorly-controlled Type II diabetes mellitus with bromocriptine. The subjects received 1.25 mg or 2.5 mg daily for 10 weeks with no other interventions. Body fat, as estimated by skinfold measurement, was reduced by 11.7% in the non-diabetic subjects. In the diabetic subjects, body fat was also reduced but to a greater extent in those subjects taking antidiabetic pills for control of their diabetes. Hyperglycemia resolved in most of the diabetics allowing cessation of hypoglycemic drugs in some. The degree of weight loss was minimal in all patients and mild nausea was the only side effect reported. 146 Encouraged by these results, the same investigators randomized 17 obese subjects to bromocriptine (1.6 or 2.4 mg daily within 2 hours of awakening of a quick-release form of bromocriptine) or placebo. In addition, all subjects were instructed to follow a moderately-low calorie diet. After 18 weeks, the subjects receiving bromocriptine had lost 6.3 kg and those receiving placebo only lost about 1 kg. Treatment with bromocriptine was also associated with a greater reduction in body fat and improved glucose tolerance.147 The way in which bromocriptine decreases fat stores and body weight and improves glucose tolerance is not known, but appetite suppression or a reduction of lipogenesis (the production of fat) have been proposed 146,147 Although these data are promising, the use of bromocriptine cannot be recommended until more information about long-term safety and efficacy is available. Bromocriptine is not currently FDA- approved for the treatment of obesity, but phase III studies are under way.
Here is some information on the increase in natural GH production from ingestion of GHB:
Increasing natural growth hormone secretion-experts observed increases in plasma GH over a period of 90 minutes after GHB took effect. These plasma GH levels reached a peak of nearly 40 ng/ml. This lead researchers to conclude that GHB supplementation stimulates the secretion of GH by the pituitary gland in human subjects. It may cause a release of GH by modifying the amount of serotonin available to the nerve terminals. One Japanese study reported nine-fold and sixteen-fold increases in growth hormone 30 and 60 minutes respectively after intravenous administration of 2.5 grams of GHB in six healthy men between the ages of twenty-five and forty. GH levels were still seven-fold higher at 120 minutes. At the same time GH is being released, prolactin levels also rise. Serum prolactin levels increase in a similar time-dependent manner as GH, peaking at five-fold above baseline at 60 minutes. This effect, unlike the release of GH, is entirely consistent with GHB's inhibition of dopamine. Other compounds which lessen dopamine activity in the brain (such as the neuroleptic Thorazine) have been shown to result in prolactin release. Although prolactin tends to counteract many of the beneficial effects of GH, the sixteen-fold increases in GH probably overwhelm the five-fold increases in prolactin. Contributing to anabolism and lypolysis-GHB activates a metabolic process known as the "pentose pathway" which plays an important role in the synthesis of protein within the body. It also causes a "protein sparing" effect which reduces the rate at which the body breaks down its own proteins. These properties, along with GHB's effect on growth hormone, underlie its common use as an aid to muscle-building and fat loss.
As most of us know, GHB and its equivalents have been shown to cause a dramatic increase in growth hormone, which we like very very much. Unfortunately, this has been associated (and at least partially offset) by a significant increase in prolactin. [See the excerpt at the bottom of this post]
The point of Fonz's post was that bromocriptine destroys prolactin. In addition, as shown in the study below, people who took bromocriptine by itself over 18 weeks lost an average of about 10 lbs. more than the people in the group receiving a placebo.
In sum, it appears that a combination of GHB and bromocriptine would result in elevated GH without a concurrent increase in prolactin. This would be a very potent fat burning combination which could be anabolic and anti catabolic as well.
Bromocriptine is available (apparently without a prescription) at http://208.234.10.47/mcart/?task=item&ItemID=IT11
Has anybody tried this, or does anybody know more about the subject?
Here is an interesting read on the fat reducing effects of bromocriptine alone, excerpted from
http://www.ispub.com/journals/IJAPA/Vol1N2/obesity2.html
Bromocriptine
Bromocriptine is a dopamine agonist the has been shown to decrease body fat stores in experimental animals with little or no reduction in body weight or food intake.145 Accordingly, Meier and colleagues treated 33 obese postmenopausal women and 15 men with poorly-controlled Type II diabetes mellitus with bromocriptine. The subjects received 1.25 mg or 2.5 mg daily for 10 weeks with no other interventions. Body fat, as estimated by skinfold measurement, was reduced by 11.7% in the non-diabetic subjects. In the diabetic subjects, body fat was also reduced but to a greater extent in those subjects taking antidiabetic pills for control of their diabetes. Hyperglycemia resolved in most of the diabetics allowing cessation of hypoglycemic drugs in some. The degree of weight loss was minimal in all patients and mild nausea was the only side effect reported. 146 Encouraged by these results, the same investigators randomized 17 obese subjects to bromocriptine (1.6 or 2.4 mg daily within 2 hours of awakening of a quick-release form of bromocriptine) or placebo. In addition, all subjects were instructed to follow a moderately-low calorie diet. After 18 weeks, the subjects receiving bromocriptine had lost 6.3 kg and those receiving placebo only lost about 1 kg. Treatment with bromocriptine was also associated with a greater reduction in body fat and improved glucose tolerance.147 The way in which bromocriptine decreases fat stores and body weight and improves glucose tolerance is not known, but appetite suppression or a reduction of lipogenesis (the production of fat) have been proposed 146,147 Although these data are promising, the use of bromocriptine cannot be recommended until more information about long-term safety and efficacy is available. Bromocriptine is not currently FDA- approved for the treatment of obesity, but phase III studies are under way.
Here is some information on the increase in natural GH production from ingestion of GHB:
Increasing natural growth hormone secretion-experts observed increases in plasma GH over a period of 90 minutes after GHB took effect. These plasma GH levels reached a peak of nearly 40 ng/ml. This lead researchers to conclude that GHB supplementation stimulates the secretion of GH by the pituitary gland in human subjects. It may cause a release of GH by modifying the amount of serotonin available to the nerve terminals. One Japanese study reported nine-fold and sixteen-fold increases in growth hormone 30 and 60 minutes respectively after intravenous administration of 2.5 grams of GHB in six healthy men between the ages of twenty-five and forty. GH levels were still seven-fold higher at 120 minutes. At the same time GH is being released, prolactin levels also rise. Serum prolactin levels increase in a similar time-dependent manner as GH, peaking at five-fold above baseline at 60 minutes. This effect, unlike the release of GH, is entirely consistent with GHB's inhibition of dopamine. Other compounds which lessen dopamine activity in the brain (such as the neuroleptic Thorazine) have been shown to result in prolactin release. Although prolactin tends to counteract many of the beneficial effects of GH, the sixteen-fold increases in GH probably overwhelm the five-fold increases in prolactin. Contributing to anabolism and lypolysis-GHB activates a metabolic process known as the "pentose pathway" which plays an important role in the synthesis of protein within the body. It also causes a "protein sparing" effect which reduces the rate at which the body breaks down its own proteins. These properties, along with GHB's effect on growth hormone, underlie its common use as an aid to muscle-building and fat loss.
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