I would think that with modern surgical implants, liposuction, rib removal and AAS, hGH, IGF-1 etc.....that genetics does not have to be limiting unless you wanna be a natty, or can't afford any of the above. If I had the moula I'd be first in line for some lipo and calf implants. The biggest reason I have not used AAS yet is that my calves are my genetically lagging bodypart, and taking AAS will not bring them up to match the rest of my body, so it won't help balance my physique. At the pro level ALL of the above are important, prolly more so than genetics. But having limbs too short or long, and muscle insertions in the wrong place will stop ya from being a top pro BB/Fitness chick. It won't stop you from being the best body that you can be within the boundaries you set for yourself though.