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Posting a recent study showing that just 20 mg androstenediol as a sublingual cyclodextrin tablet had real effects on hormone
levels. This study shows the form the andro
comes in is essential to getting a measurable effect.
J Appl Physiol 2002 Jan;92(1):142-6
Acute hormonal response to sublingual androstenediol intake
in young men.
Brown GA, Martini ER, Roberts BS, Vukovich MD, King DS
Exercise Biochemistry Laboratory, Department of Health and
Human Performance, Iowa State University, Ames, Iowa 50011,
USA.
The effectiveness of orally ingested androstenediol in
raising serum testosterone concentrations may be limited
because of hepatic breakdown of the ingested androgens.
Because androstenediol administered sublingually with
cyclodextrin bypasses first-pass hepatic catabolism, we
evaluated the acute hormonal response to sublingual
cyclodextrin androstenediol supplement in young men.
Eight men (22.9 +/- 1.2 yr) experienced in strength training
consumed either 20 mg androstenediol in a sublingual
cyclodextrin tablet (Sl Diol) or placebo (Pl) separated by
at least 1 wk in a randomized, double-blind, crossover
manner. Blood samples were collected before supplementation
and at 30-min intervals for 3 h after supplementation. Serum
hormone concentrations did not change with Pl. Serum
androstenedione concentrations were increased (P < 0.05)
above baseline (11.2 +/- 1.1 nmol/l) with Sl Diol from 60 to
180 min after intake and reached a peak concentration of
25.2 +/- 2.9 nmol/l at 120 min. Serum free testosterone
concentrations were increased from 86.2 +/- 9.1 pmol/l with
Sl Diol from 30 to 180 min and reached a peak concentration
of 175.4 +/- 12.2 pmol/l at 60 min. Serum total testosterone
concentrations increased above basal (25.6 +/- 2.3 nmol/l)
from 30 to 180 min with Sl Diol and reached a peak
concentration of 47.9 + 2.9 nmol/l at 60 min. Serum
estradiol concentrations were elevated (P < 0.05) above
baseline (0.08 +/- 0.01 nmol/l) from 30 to 180 min with Sl
Diol and reached 0.14 +/- 0.02 nmol/l at 180 min. These data
indicate that sublingual cyclodextrin androstenediol
intake increases serum androstenedione, free testosterone,
total testosterone, and estradiol concentrations.
levels. This study shows the form the andro
comes in is essential to getting a measurable effect.
J Appl Physiol 2002 Jan;92(1):142-6
Acute hormonal response to sublingual androstenediol intake
in young men.
Brown GA, Martini ER, Roberts BS, Vukovich MD, King DS
Exercise Biochemistry Laboratory, Department of Health and
Human Performance, Iowa State University, Ames, Iowa 50011,
USA.
The effectiveness of orally ingested androstenediol in
raising serum testosterone concentrations may be limited
because of hepatic breakdown of the ingested androgens.
Because androstenediol administered sublingually with
cyclodextrin bypasses first-pass hepatic catabolism, we
evaluated the acute hormonal response to sublingual
cyclodextrin androstenediol supplement in young men.
Eight men (22.9 +/- 1.2 yr) experienced in strength training
consumed either 20 mg androstenediol in a sublingual
cyclodextrin tablet (Sl Diol) or placebo (Pl) separated by
at least 1 wk in a randomized, double-blind, crossover
manner. Blood samples were collected before supplementation
and at 30-min intervals for 3 h after supplementation. Serum
hormone concentrations did not change with Pl. Serum
androstenedione concentrations were increased (P < 0.05)
above baseline (11.2 +/- 1.1 nmol/l) with Sl Diol from 60 to
180 min after intake and reached a peak concentration of
25.2 +/- 2.9 nmol/l at 120 min. Serum free testosterone
concentrations were increased from 86.2 +/- 9.1 pmol/l with
Sl Diol from 30 to 180 min and reached a peak concentration
of 175.4 +/- 12.2 pmol/l at 60 min. Serum total testosterone
concentrations increased above basal (25.6 +/- 2.3 nmol/l)
from 30 to 180 min with Sl Diol and reached a peak
concentration of 47.9 + 2.9 nmol/l at 60 min. Serum
estradiol concentrations were elevated (P < 0.05) above
baseline (0.08 +/- 0.01 nmol/l) from 30 to 180 min with Sl
Diol and reached 0.14 +/- 0.02 nmol/l at 180 min. These data
indicate that sublingual cyclodextrin androstenediol
intake increases serum androstenedione, free testosterone,
total testosterone, and estradiol concentrations.
