The Only pct I endorse at this time right now is in my Article here
http://www.elitefitness.com/forum/a...e-support-drug-steroid-user-bible-778853.html
This Article above Brakes down Pct and blows your mind with the amount of knowledge and supporting evidence/writing/literature ^^^
First off I would like to say if you cant sit through something like this and read the whole thing. Then you really have no business taking these kinds od drugs in the first place. You also have no business making a comment on this thread ether. Thanks.
What Is Nolvadex/Tamoxifen?
Tamoxifen is considered as the antagonist of the estrogen receptor which again is primarily present in the breast tissue of the human body. It is interesting to note that certain breast cancer cells require that the estrogen levels need to grow with passing time. Ideally, Tamoxifen has been used as the standard endocrine for the treatment of early breast cancer patients. It is therefore used as an anti estrogen therapy and it is mainly given to postmenopausal women. The role of an estrogen is to bind as well as activate the estrogen receptors that are present in the breast cells of a human body. The role of Tamoxifen is to stop estrogen to bind with the receptor. Although it is metabolized into compounds that aid in the binding of estrogen receptors, Tamoxifen does not allow the estrogen receptors to get activated in the breast cells of the human body. Hence, the growth of breast cancer cells can be stopped by making use of this compound. Nonetheless, results vary from person to person and the use of Tamoxifen cannot be deduced as a permanent cure for breast cancer patients.
It is ideally a drug which is taken orally in the form of an edible tablet and it is known to interfere with the activity of the estrogen levels present in the breast tissue. It has been studied that unless the estrogen levels in the human body are kept under strict control, they can lead to breast cancer. Tamoxifen has primarily been used for the past 30 years for treating patients suffering from breast cancer. It has also been administered to patients who are in their early stages of breast cancer. Even patients whose breast cancer has spread to various parts of the body have been known to use Tamoxifen on a regular basis. It has been stated that this drug has the ability to stop cancer cells from spreading within the human body but ironically there is no substantial study which clearly backs this statement with the help of substantial proof. Nonetheless, owing to the hype that it has received via media, people who are having breast cancer or those women who run the risk of developing breast cancer have been known to take this medicine on a regular basis. Interestingly, it has also been seen that women who are suffering from ductul carcinoma in stu, which in turn is similar to invasive breast cancer, have also been known to administer this medicine on a regular basis.
In the past 20 years steroid users have been using nolvadex for a number of reasons. To ether help reduce bloat or gyno problems during a cycle or after a cycle to help recovery natural test production. In men, tamoxifen "nolvaldex" is sometimes used by steroid-taking, weight-training athletes.An alternative and highly similar compound is clomiphene citrate "clomid". These drugs are used as anti-estrogen therapy. In this regard, the drug is used for three purposes. The first purpose, is to
reduce the effect of circulating estrogens even if Tamoxifen itself increase the circulating level of estrogens since they are not bound to the estrogen receptors. Abnormally high levels of estrogen in men, can be caused by taking highly aromatizing anabolic steroids e.g. Dianabol, Anadrol or Testosterone. In dosing with a dosing with 20 mg of Novaldex (Tamoxifen) for the duration of a steroid cycle, a reduction in water retention can be achieved. This prevents large fluctuations in water weight within the muscle.
Using Tamoxifen for the duration of a steroid cycle may or may not promote a preferable outcome for a weight training athlete, as the temporary increase in water weight within the muscle increases strength and allows larger weights to be used for the duration of the steroid cycle. Said water will dissipate once usage of steroids has ceased, and a dramatic loss in weight can be observed. Tamoxifen is also used to prevent estrogen related gynecomastia, resulting from elevated estrogenic levels. It can be taken as a preventative measure in small doses, or used at the onset of any symptoms e.g. nipple soreness/sensitivity. In the latter case, dosing reverses the affliction
However it Is now well known that well taking nolvadex serum level estrogen raises and yet another drug must be taken with it during cycle,during pct,or after pct to prevent estrogen rebound. (how retarded). Studies have of course shown the its use can cause a rise in lh and test production but at what cost? Many other factors must be taken into account.
All this is happening in complete ignorance as they are not aware that this medicine has certain side effects that can prove fatal in the longer run. At the same time robbing ones self of a better pct and cycle from using drugs like this.
Though I do feel its "ok" to use them "if you must" but use as little as you can and use support/pct sups to help alleviate the side effects and bad feelings one gets from these harsh drugs.
Where Was This drug Discovered?
Interestingly, this drug was discovered by AstraZeneca Pharmaceuticals which were earliest known as ICI pharmaceuticals. It is now sold under various trade names such as Nolvadex, Valodex and Istubal. Although it is sold under various names, it is primarily known and popularly termed as Tamoxifen. Although this drug is widely used in treating breast cancer patients, it also has adverse side effects which very few people are actually aware off.
Once praised for its benefits in preventing breast cancer recurrence, the lucrative pharmaceutical drug tamoxifen is now implicated in causing dangerous side-effects, including other types of cancers.
In the early 1970's, a shameful chapter closed on the widespread use of a known carcinogenic and endocrine-disrupting drug called DES (diethylstilboestrol), the first synthetic, non-steroidal estrogen drug. Against the advice of its creator, Sir Charles Dodd, between four and six million American and European women and 10,000 Australian women innocently used DES for the prevention of miscarriage and pregnancy complications.
In addition, DES became a popular though unproven drug for a variety of other conditions. It was used for the suppression of lactation, the treatment of acne, the treatment of certain types of breast and prostatic cancer, and as an inhibitor of growth in young girls, an estrogen replacement in menopause and a "morning after" pill.
It would take 30 years to accept what laboratory tests had indicated as early as 1938 — that DES was a highly dangerous and harmful drug. It was reported that, 20 years after taking DES, mothers had a 40 to 50 per cent greater risk of breast cancer than non-exposed mothers. In addition, the children of DES mothers showed a high incidence of reproductive abnormalities, miscarriages, vaginal cancer, testicular cancer, sterility and immune dysfunction. In fact, it is feared that repercussions of this drug will be felt for generations to come.
The irony of this entire debacle is that the medical establishment finally acknowledged that DES was useless in preventing miscarriages. Thus, DES, another disastrous experiment on women, was added to the long list of major medical blunders.
Out of this early research, a new drug appeared on the horizon which would be soon be heralded as a shining star in the war against the growing epidemic of breast cancer. In the late 1960's the pharmaceutical industry developed a drug called "tamoxifen". As a synthetic, non-steroidal compound with hormone-like effects (many of which are poorly understood), tamoxifen has a similar structure to DES. In fact, it was observed that tamoxifen caused the same abnormal changes seen in cells of women taking estradiol and DES. This similarity raised alarm bells for some.
Pierre Blais, well known as a drug researcher who was ejected from Canada's health protection bureaucracy when he spoke out about silicone breast implants, describes the story of tamoxifen as "the story of modern drug design which produces garbage drugs". He says, "Good drug design ceased, unfortunately, in the 1930s." Tamoxifen, Blais asserts, "...
is a garbage drug that made it to the top of the scrap heap. It is a DES in the making."
Blais's dire predictions were ignored with the promise of a potential drug treatment for breast cancer.
Tamoxifen was first approved by the US Food and Drug Administration (FDA) for use as a birth-control pill; however, it proved to induce rather than inhibit ovulation.(just goes to show how retarded they truly are) Although tamoxifen didn't work as a contraceptive, it was found to lower mammary cancer rates in animals. Animal studies showed that tamoxifen prevented estrogen from binding to receptor sites on breast tissue cells. Tamoxifen also reduced the incidence of breast cancer in rodents after administration of a breast-carcinogenic substance. This discovery provided the impetus to study its effects in treating human breast cancer.
Estrogen is the common link between most breast cancer risk factors, i.e., genetic, reproductive, dietary, lifestyle and environmental. It both stimulates the division of breast cells (healthy as well as cancerous) and, especially in its 'bad' form, increases the risk of breast cancer. Thus, hormonal drugs such as tamoxifen that block the effects of estrogen on the breast were expected to reduce the risk of breast cancer recurring in women treated for breast cancer.
Tamoxifen acts as a weak estrogen by competing for estrogen receptors much as phyto-estrogens do(I want you to keep this word PHYTO ESTROGENS IN MIND WE WILL COVER IT AGAIN LATER). Like phyto-estrogens, tamoxifen has mild estrogenic properties but is considered an anti-estrogen since it inhibits the activity of regular estrogens. More accurately, tamoxifen is an
estrogen-blocker(Not a estrogen reducer)
HORMONAL EFFECTS OF TAMOXIFEN IN OLIGOSPERMIC MEN
Yes the test shows over time that both lh and androgins were raised, but at the same time (serum level estrogen was tripled)and thus the reason many experence rebound gyno after its use.
Tamoxifen fights breast cancer by competing with estrogen for space on estrogen receptors in the tumor tissue. Every tamoxifen molecule that hooks onto an estrogen receptor prevents an estrogen molecule from linking up at the same site. Without a steady supply of estrogen, cells in an estrogen-receptor-positive (ER+) tumor do not thrive and the tumor's ability to spread is reduced.
However, tamoxifen exhibited two conflicting characteristics. It could act either as an anti-estrogen or as an estrogen. Therefore, while tamoxifen is anti-estrogenic to the breast, it also acts as an estrogen to the uterus and, to a lesser extent, the heart, blood vessels and bone. Moreover tamoxifen also acts as an estrogen in the liver thus causing the lowering of IGF-1
In This Issue -- 82 (21): 1661 -- JNCI Journal of the National Cancer Institute
http://cancerres.aacrjournals.org/cgi/reprint/49/7/1882.pdf
Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women
Comparison of Tamoxifen and Testosterone Propionate in Male Rats: Differential Prevention of Orchidectomy Effects on Sex Organs, Bone Mass, Growth, and the Growth Hormone-IGF-I Axis -- Fitts et al. 25 (4): 523 -- Journal of Andrology
For people suffering from breast cancer I guess this would be a good thing. Since Lowering IGF would reduce the growth of everything. However this is not one any of the people using nolva for pct or on cycle use want now is it?
So, although it initially showed the tendency to counter breast cancer recurrence, it would soon be revealed that it also promoted particularly aggressive uterine and
liver cancers, caused fatal blood clots and interfered with many other functions.
Doctors, however, were quick to jump on the tamoxifen bandwagon, turning a blind eye to its more injurious tendencies. Starting in the 1970's oncologists began using tamoxifen to treat women with cancer, often in combination with other drugs, radiation or surgery such as lumpectomy and mastectomy, with modest success. Like DES, tamoxifen's benefits were then extended for use as a preventive against osteoporosis and heart disease.
Today, doctors are treating about one million American breast cancer patients with tamoxifen, about 20 per cent of them for more than five years. As studies published in the New England Journal of Medicine in 1989 and the Journal of the National Cancer Institute in 1992 showed, women with breast cancer who took tamoxifen reduced their chances of developing cancer in the other breast (contralateral cancer) by about 30 to 50 per cent. These findings would later be challenged.
Tamoxifen is now recommended for all pre-menopausal women with hormone-positive cancers, as well as for most postmenopausal women with breast cancer and/or a growing number of women with hormone-negative cancers. Tamoxifen is currently used by more women with breast cancer than any other drug.
Tamoxifen (brand name Nolvadex) is now the most widely prescribed cancer medication in the world. It generated revenues of US
$265 million in 1992. By 1995, worldwide sales of Nolvadex reached $400 million. (7) And at AUD $90 for one month's supply, it doesn't come cheap (the Australian Pharmaceutical Benefits Scheme covers $70).
Global sales of tamoxifen in 2001 were $
1,024 million.[54] Since the expiration of the patent in 2002, it is now widely available as a generic drug around the world. Barr Labs Inc had challenged the patent (which in 1992 was ruled unenforcable) but later came to an agreement with Zeneca to licence the patent and sell tamoxifen at close to Zeneca's price.[55] As of 2004, tamoxifen was the world's largest selling hormonal drug on record and off record may be the number 1 selling drug in word of all time to date. So we are truly talking about billions in revenue world wide for drug companies,sources,ug's and more. Money is at the root of this drug and why its so heavily pushed on all forums by everyone. Its cheap to make and it brings in billions plain and simple.
These numbers are nothing compared to what this drug now makes for the drug companies,sources.ug's selling it. So you can bet your life they will make sure every test and study in the world is published to make sure its seen in a good light. This not even including its "off label use" Ie all us men using it for on cycle and pct. The use of the drug for this reason triples its sales and you can just emagen the amount of money its making. You do the math my friends!. At this very moment 500000000 sources and people with monitary ties to this drug are out there pushing like crazy to make sure you and everyone else keeps its use for pct alive. This is the #1 reason why we have not given up on this years ago.
Tamoxifen was developed by UK-based Imperial Chemical Industries (ICI), one of the world's largest multinational chemical corporations. Zeneca, an ICI subsidiary, is responsible for manufacturing and marketing the hormone and is now the world's largest cancer-drug company.
CARCINOGENENIC EFFECTS
It wasn't long before laboratory studies showed that tamoxifen acted as a
carcinogen. It has been found that tamoxifen binds tightly and
irreversibly to DNA, the genetic blueprint of a cell, causing a cancerous mutation to take place. Even Australia's conservative National Health and Medical Research Council (NHMRC) warned that no amount of tamoxifen is safe when it comes to carcinogenic effects.
In California there is a law called "Proposition 65" that requires the state to publish and maintain a list of all known carcinogens. In May 1995,
the state's Carcinogen Identification Committee voted unanimously to add tamoxifen to its list.
When research is done on anti-cancer drugs (such as SERMs), the aim is to find a drug that prolongs life, with the least amount of acute side-effects. In other words, the goal isn’t so much about finding a cure, as it is finding something that can alleviate the symptoms and/or prolong life.
When it comes to steroid users so many are willing to forgo any and everything to get the one simple effect they desire (recovery). The popularity of these drugs stems from the popular advice to use these drugs for everything from testosterone recovery.bitch tits,make your dick grow bigger, increase the amount of jiz you drop on a girls face, and everything in between. Advice on its use is handed out like candy and everyones got a sweat tooth for quick advice. Of course many "vets and so called know it alls" defend it to the death and it can do no wrong. Mainly do to not wanting to be wrong,habit,they got money involved with it, or just for the sake of argument.
“Its FDA approved for cancer treatment. It must be safe!”
It’s wrong to assume that an “FDA approved” drug has a proven safety profile. The FDA has continually issued stronger health warnings for tamoxifen over the years. For instance, in 1994 the FDA demanded that the tamoxifen manufacturer Zeneca (an ICI sub-division), issue warning letters to health care practitioners about the increased risk of endometrial and gastro-intestinal cancers with tamoxifen use. Zeneca also reported adverse effects similar to those seen with DES, such as reproductive abnormalities in the animals whose mothers received tamoxifen. (remember, DES was the original synthetic estrogen, and also an analog to tamoxifen)
A number of cancer researchers have pointed out the health risks too, such as Elwood et al (6) -
“[Tamoxifen], therefore, is not appropriate for use in the general population because of the known increased risk of endometrial cancer”
What Are Side Effects Of Temoxifen
You Can Get Blood Clots!
Have you any idea that a regular dosage of Tamoxifen can actually increase the chances of blood clots? Well, this is a true fact and can be fatal for those who are using this drug to get rid or avoid the chance of getting Gyno on cycle and or for pct. According to recent medical studies, it has been noticed that people who have been using Tamoxifen on a regular basis have had a substantial increase in terms of their blood clots. Hence, as compared to those people who are not using this drug, their chances of getting blood clots is relatively higher.
A blood clot can be defined as an internal body mechanism by which the cut can be stopped from bleeding excessively. The proteins present in your blood work along with the platelets and in a bid to form a clot. This is also termed as coagulation. In the event of an injury, this can prove to be really very effective as it would stop the flow of blood from your wound and thus save your life. Nonetheless, if the blood clots while it is moving through your body, it can prove fatal. This is also termed as hyper coagulation and it can prove very dangerous for the concerned individual. Tamoxifen has been known to cause hyper coagulation and hence, it needs to be taken under strict medical supervision.
When the study was conducted, it was ascertained that a relatively large number of people developed this conditions and although not many people using this drug were actually studied, those that were using it regularly, were in a shock to find out that it also led to blood clots.
Hence, although this drug is helpful to a certain extent, we need to also see that the extent of damage it can do to our body in terms of hazardous blood clots are much more and hence, you as a steroid user need to exercise caution and spend some quality time researching on this so called ‘wonder-drug’ before making it an eminent part of your daily routine and or pct.
One of the main reasons why a blood clot is considered dangerous is because this drug causes a clot inside the blood vessel which in turn is known as thrombus. What happens is that at times this blood clot can travel through your blood streams and get pushed into your lungs. When this happens, you can be rest assured that your life is in acute danger as this condition is life threatening. This condition is also known as pulmonary embolus. Similarly, a clot this clot can also block the blood vessels in the brain and this in turn may lead to a stroke. When this blood clot clocks the blood vessels of your heart, it stops the blood from rushing to your heart area thereby reducing the oxygen supply to that area. This in turn leads to cardiac arrest.
All the above mentioned conditions arising from blood clots, which in turn are caused from a regular intake of Tamoxifen, can prove to be life threatening for the concerned individual. Hence, even before you decide to take this medication on a regular basis, you need to exercise caution and be prepared to face the ill effects of this so called ‘wonder-drug’.
Increased susceptibility to gyno -
Tamoxifen is often used to combat gyno during cycle when “flare ups” occur. While tamoxifen may provide immediate inhibition of proliferation, and serve as valuable tool, it can actually increase future susceptibility to gyno.
This is caused by tamoxifen’s ability to up-regulate the progesterone receptor. (54-56) This can dramatically increase the chances of developing gyno in future cycles when utilizing progestin based anabolics such as Nandrolone (Deca) or Trenbolone (or any pro-hormone acting upon the progesterone receptor).
It is interesting to speculate. Is tamoxifen use directly related to the increased gyno occurrences seen with modern day steroid users?
You Can Develop Cataract!
Cataract can be defined as a thin white layer of membrane which blocks the passing light to the retina thereby clouding your vision. Although it is relatively painless, it does cloud your vision and can even blind you if it is not removed through the means of a surgical procedure. The retina is ideally a nerve layer which is located at the back of the eye socket and its main purpose is to direct the light which is entering the eye via the means of electromagnetic signals to the brain. Once the brain receives these nerve signals, it is passed on to the nervous system, after which you can transform your vision into clear moving pictures. If this thin layer of membrane is blocked owing to any reason, you would have problems with your vision.
While aging is looked on as the major cause behind cataract, it has recently been noticed that patients using Tamoxifen have been identified as ones susceptible to cataract on a regular basis. people who are aging and using this drug on a regular basis are on a higher risk of contracting cataract as compared to those who are not using Tamoxifen. The other eye problems that can be faced by individuals include scarring of the corneal area and abrupt retinal changes.
In case you are using this drug regularly and you have a cloudy, fuzzy or foggy vision, you need to get your eyesight checked with immediate effect. In case you are unable to withstand the glare of lamps and are unable to catch a glimpse of the morning sun, then again you need to get your eyes checked. This is so because, Temoxifen has a natural tendency to obstruct the normal eye vision and if you do suffer from this symptom, you may not be able to drive at night as the headlamps of the opposing vehicle may blind you momentarily.
In order to get rid of cataract that has been developed owing to a continuous intake of Temoxifen, you may need to undergo a corrective surgery. In case you want to delay a surgical procedure, you may want to light up your room with plenty of tubes and bulbs and keep your eyeglass up to date with the latest prescription. Ideally, the only known cure for cataract that has been a resultant of Temoxifen is a surgical procedure.
If you would like to avoid this problem, you would have to seek an alternative to Temoxifen at the earliest given opportunity.
Libido reduction & erectile dysfunction
Erectile dysfunction ow libido, and general impotence are typical complaints from men recently discontinuing steroids or HRT therapy, which is often combated by Clomid or Nolvadex, paradoxically so.
Regardless of any positive effects on fertility or testosterone levels, Clomid and Nolvadex use is highly correlated with erectile dysfunction, libido suppression, and even emotional disorders Research with male breast cancer patients has also reported decreased libido, and thrombosis associated with tamoxifen use. he thrombotic effect (blood vessel clogging) could explain the mechanism by which SERMs may inhibit erectile function, by reducing circulation to erectile tissue (as discussed before)
Nolva/clomid both raise shbg.
This is something I do not see a lot of people disusing so I I wanted to make it well know. Just do a web search on TAMOXIFEN,clomid or nolva raises shbg or any variation and you will get all the studies and prof you need.
Trait Anxiety and Tamoxifen Effects on Bone Mineral Density and Sex Hormone- Binding Globulin -- Cameron et al. 64 (4): 612 -- Psychosomatic Medicine
iHOP - Information Hyperlinked over Proteins [ SHBG ]
Sex Hormone Binding Globulin in Clinical Perspective; Acta Obstetricia et Gynecologica Scandinavica - 66(3)
ages 255-262 - Informa Healthcare
Wiley InterScience :: Session Cookies
2. Nolva lowers Igf-1 Again just a simple search on (TAMOXIFEN or nolva lowers IGF 1 and walla you got all the prof you need.
In This Issue -- 82 (21): 1661 -- JNCI Journal of the National Cancer Institute
http://cancerres.aacrjournals.org/cgi/reprint/49/7/1882.pdf
Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women
Comparison of Tamoxifen and Testosterone Propionate in Male Rats: Differential Prevention of Orchidectomy Effects on Sex Organs, Bone Mass, Growth, and the Growth Hormone-IGF-I Axis -- Fitts et al. 25 (4): 523 -- Journal of Andrology
They can cause Major triglyceride and glucose problems and even to the point of Severe hypertriglyceridemia or also Pancreatitis
Severe hypertriglyceridemia caused by tamoxifen-tr... [Endocr J. 1997] - PubMed result
Tamoxifen-induced hypertriglyceridemia in association with diabetes mellitus - EM|consulte
SpringerLink - Journal Article
Capecitabine-Induced Severe Hypertriglyceridemia: Report of Two Cases -- Kurt et al. 40 (2): 328 -- The Annals of Pharmacotherapy
Elsevier: Article Locator
Estrogen and Triglycerides
http://annonc.oxfordjournals.org/cgi/reprint/11/8/1067.pdf
WikiGenes - Hypertriglyceridemia
A word on clomiphene (Clomid) –
Clomiphene (Clomid) consists of two stereoisomers which possess radically different pharmacodynamics. Zuclomiphene has predominantly estrogenic effects and slow clearance while the enclomiphene isomer has predominately anti-estrogenic effects and quick clearance. his creates a divergent effects between estrogen blockage and estrogen stimulation and an acute imbalance once Clomid administration is discontinued. Bodybuilders will often complain of “estrogenic rebound” after stopping Clomid, which could be attributed to the lingering estrogenic isomer zuclomiphene as the anti-estrogenic enclomiphene has long cleared the system. (Recently, enclomiphene has been isolated by the pharmaceutical company Repros, for use in Androxal™.)
For all intents and purposes, tamoxifen is a superior SERM, simply for the fact that tamoxifen provides a purely anti-estrogenic isomer, whereas Clomid provides a mix of anti and pro estrogenic effects.
In regards to the health consequences about to be listed, it can be safely assumed that Clomid will share similar detrimental effects as tamoxifen, since it shares the same triphenylethylene backbone and carcinogenic tendencies.
One of the main reasons why people make use of Clomid is for the purpose of recovering their bodies after a steroid cycle In simple words, this drug is mainly used in the form of post cycle therapy. Clomid has the actual potential to stimulate the production of hypothalamus which in turn would release a particular kind of hormone called gonadotrophic hormones. This hormone has the natural ability to allow the human testicles to secrete testosterone, which in turn would bring the depleting levels of testosterone in the body to its permissible levels. When this is achieved, the human body would stop losing its muscle mass in a natural way. Reacovery of test production is the gaols at any cost is the common thought.
Its a known fact that both clomid and nolvadex cause some really messed up mood swings.
Clomid/nolva have been known to cause severe mood swings in users and it has apparently been noticed that anyone who has been making use of Clomid/nolva have suffered from such side effects on a regular basis. Many users have categorically complained that the use of Clomid has been considered as the worst side effect that they have suffered so far. A few features of mood swings may include a change in the usual behaviour, tearful behaviour, excessive depression, anxiety and extremely sensitive in nature. Stop acting like you don't know what I am talking about. We all know its true.
Liver cancer -
Originally, tamoxifen was accepted as being non-toxic to the human liver upon finding that tamoxifen did not cause noticeable liver damage (DNA adducts) during short-term test tube studies with human liver cells.
However, it became apparent that test tube research was largely flawed due to the low rate of metabolism in such a superficial environment. It was soon discovered that the hepatotoxic effects from tamoxifen stem from the metabolism and buildup of the a-hydroxytamoxifen and N-desmethyltamoxifen metabolites, which would only appear in an in vivo environment. Surely enough, the results from the original rat studies showing dramatic carcinogenic effects on the liver, soon correlated with human data when researchers found the same type of liver DNA adducts in tamoxifen patients.
More recent human research has reported tamoxifen treated women to have 3x the risk of developing fatty liver disease, which occurs as soon as 3 months into therapy at only 20mg/day. In some cases, the disease lasts up to 3 years, despite cessation of tamoxifen therapy. Five and ten year follow-ups with patients on long term tamoxifen therapy show cases of deadly hepatocellular carcinoma.
In 2002, a bizarre study examined the use of tamoxifen for hepatocellular carcinoma treatment in humans. It was assumed that since tamoxifen could inhibit proliferation of breast cancer, it could offer the same benefit for liver cancer. The devastating results could not have been more indicative of tamoxifen’s hepatotoxic nature, as the tamoxifen treatment significantly increased the rate of death, compared to the group not receiving tamoxifen.
Finally, in a case study reviewing tamoxifen induced liver disease; D.F Moffat et al made a profound statement –
“Hepatocellular carcinoma in tamoxifen treated patients may be under-reported since there may be reluctance to biopsy liver tumours which are assumed to be secondary carcinoma of the breast.” In other words, it appears that liver carcinomas from a large number of breast cancer patients on tamoxifen therapy have been misdiagnosed as an infection from the breast cancer itself.
Although tamoxifen induced liver cancer may take years to manifest in a healthy male, its damaging effects could easily be exaggerated by other popular hepatotoxic drugs, such as 17aa oral steroids.
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Testosterone it’s What separates the men from the boys
Remember what it was like to be young and full of testosterone? The day you used to wake up with a massive rock hard morning wood and at that time in your life hardly even knew what to do with it. How about the good old days when you could down a package of Oreo’s with a gallon of milk without even gaining a single pound? What about that feeling of power and cockiness that was always present with you as a young man. Feeling like king of the world, no one could stand in your way and every woman on earth wanted to you because you were so perfect in every way. Oh yes those sure where the days that have long since passed, Or have they? Are these days gone forever or can we regain some of these feelings once again?
Testosterone is a lot more than just the pesky hormone that gets young boys into trouble. It’s responsible for much more than a teenage boys rebellion well going through the changes of life. Thankfully we have learned much more about testosterone. Immaturity is what gets a young man in trouble, but testosterone is what separates the men from the boys.
What is Testosterone?
Testosterone is a steroid hormone from the androgen group and is also the MAIN hormone in a male’s body. In mammals, testosterone is primarily secreted by the testes of males and by the ovaries of females, while a tiny amount is also secreted by the adrenal glands. It is the main male sex hormone and an anabolic steroid. Testosterone plays a key role in the development of male reproductive tissues which are the testis and prostate. Testosterone also promotes secondary sexual characteristics such as increased muscle and bone mass, hair growth, sexual behavior, development of the male genitals, increased glands, and sperm production. The adult human male body produces about ten times more testosterone than an adult human female body, but females are more sensitive to the testosterone. The brain and the bones are two important tissues in humans where the main effect of testosterone is carried out by way of aromatization to estradiol. Testosterone in the bones allows estradiol to accelerate maturation of the cartilage into bone, leading to closure of the epiphyses and end of growth. This in short explains why when young girls reach menarche, their growth starts to stunt. Estradiol serves as the most important feedback signal to the hypothalamus which triggers LH production. Testosterone is derived from cholesterol which is why people who suffer from cholesterol issues usually have low testosterone. Testosterone is a hormone that is triggered through the HPTA (hypothalamus). When the HPGA Axis is stimulated, the hypothalamus secretes gonadotropin-releasing hormone (GnRH), which on reaching the anterior pituitary, binds to the gonadotrophs and stimulates the release of both the luteinizing hormone (LH) and follicle stimulatinghormone (FSH) into the bloodstream. In the testes, testosterone is produced by the Leydig cells. The male generative glands additionally contain Sertoli cells which require testosterone for spermatogenesis. Like most hormones, testosterone is supplied to target tissues in the blood where much of it is transported bound to a specific plasma protein gondal, called the "sex hormone binding globulin" otherwise known as (SHBG). In males, LH binds to Leydig cells, stimulating production of the principal Leydig cell hormone, testosterone. Testosterone is secreted to the plasma and also carried to Sertoli cells by androgen binding protein (ABP). In Sertoli cells the 4 double bond of testosterone is reduced, producing dihydrotestosterone. A little more than 5% of testosterone is reduced to 5a-dihydrotestosterone (DHT) by the cytochrome through the enzyme 5a reductase. The conversion of testosterone to DHT leads to more sebaceous glands which in turn can leads to oily skin and acne. Less than 1% of testosterone is converted into estradiol by aromatase; also known as the CYP19A1 enzyme. Going back to the Sertoli Cells, in these cells it is regulated by FSH, again acting through a cAMP- and PKA-regulatory pathway. In addition, FSH stimulates Sertoli cells to secrete androgen-binding protein (ABP), which transports testosterone and DHT from Leydig cells to sites of spermatogenesis. There testosterone acts to stimulate protein synthesis and sperm development. Aromatase activity is also found in granulosa cells, but in these cells the activity is stimulated by FSH. Typically, then the cal-cell androgens produced in response to LH distribute to granulosa cells, whereas granulosa cell aromatase converts these androgens to estrogens. As granulosa cells mature they develop capable large numbers of LH receptors in the plasma membrane and become increasingly receptive to LH, increasing the amount of estrogen created from these cells. If not controlled it could lead to problems such as suppressed testosterone or gynecomastia due to the excess E2 levels. In a real short simplified expression; more SHBG leads to more Estrogen which leads to eventual negative effects.[2] Testosterone biosynthesis involves the cleavage of the sidechain of cholesterol by CYP11A, a mitochondrial cytochrome P450 oxidase with the loss of six carbon atoms to become pregnenolone ( the master precursor to all hormones). Next, two additional carbon atoms are removed by the CYP17A enzyme in the endoplasmic reticulum to give up a variety of carbon 19 steroide. In addition, the 3-hydroxyl group is oxidized by 3-ß-HSD to produce androstenedione. In the final and rate limiting step, the C-17 keto group androstenedione is condensed by 17-ß hydroxysteroid dehydrogenase to give way to testosterone.
From reading this explanation of how testosterone is produced even the untrained eye can see a few easy ways one can increase their testosterone production. By increasing the master hormone pregnenolone, by increasing Lutinizing hormone, and or by lowering shbg are just some of the many ways one can begin to raise natural test levels and gain its benefits once again.
Testosterone’s effect on blood Glucose Levels
Androgen (specifically testosterone) deficiency has in recent times come to the forefront of the medical literature after being overlooked for decades. The popularity of hypogonadism is greater than previously thought. Important links are being developed and established in the literature between androgen deficiency and metabolic disorders. There is an important health impact related to metabolic syndrome, insulin resistance, type 2 diabetes, and eventually vascular disease and ERECTILE DYSFUNCTION! Low concentrations of testosterone are associated with insulin resistance and mixed up in hyperglycemia, hypertension, dyslipidemia, and an increased risk of vascular disease. The increasing number of individuals with obesity and low testosterone continue to show the same continuous pattern. I came across a study that consisted of over 6000 men, the men with higher serum levels of testosterone were at much lower risk of type 2 diabetes than men with lower levels of testosterone. [6] Low testosterone demonstrated to have adverse effects on insulin levels and sudden spurts in blood glucose levels. From research lower total testosterone levels leads to less insulin resistance which equates to more body fat distribution. Research indicates insulin is capable of stimulating testosterone production in vivo and at the same time reducing SHBG concentrations in both normal-weight and obese men. Since testosterone SIGNIFIGANTLY boosts insulin sensitivity it also gives leeway for glycemic control which allow one to EAT MORE CARBOHYDRATES without any problem whatsoever! This explains why you hear people saying “when I was a young dude I was able to pound two quarter pounders with NO problem, but now if I eat one quarter pounder I get extremely bloated, those were the good old days.”
Aside from raining testosterone levels there are also powerful products that can have a outstanding positive effect on healthy insulin sensitivity. one such product of this nature would be Need2slin Need2slin and also
Testosterone is the Fountain of Youth?
Here is a small excerpt from a study that shows how testosterone declines within age which affects many organs and functions of the body. “Concentrations of sex steroids (especially testosterone) in serum decline progressively with age in men, as a result of complex alterations in reproductive physiology secondary causes of gonadal dysfunction and lifestyle factors and changes in the levels of binding proteins. Treatment of hypogonadism in younger and older men may result in an improvement in some relevant measures (e.g. osteopenia, sexual dysfunction, and muscle weakness). The average age of the study sample was 73 years of age and 389 (15%) were age 80 or older. Approximately 75% were Caucasian. Most reported themselves to be in excellent or good health compared with their peers. There were few current smokers, but a large proportion had smoked in the past. Alcohol consumption was four drinks per week on average. With the exception of race, distributions of these characteristics were not significantly different from those in the entire MrOS cohort. As men age; their SHBG levels rise and their total/free testosterone drops along their estradiol levels causing a loss in bone density. Higher BMI was related to lower testosterone and SHBG levels and higher estradiol concentrations. Total and free testosterone levels were slightly higher in men who rated their health status as excellent/good compared with those who rated it as fair/poor/very poor and were slightly higher in current smokers. Total testosterone levels were lower in Asian men and higher in African-American and Hispanic men. Free testosterone levels differed significantly by race (unadjusted P < 0.001; age- and BMI-adjusted P < 0.001) following the same trends as for total testosterone. No significant differences in total estradiol by race category were found. Unadjusted free estradiol differed slightly by race (P < 0.03) with whites having the lowest free estradiol concentration; however, after adjusting for age and BMI, the differences by race category diminished. SHBG concentrations differed by race category with Asian men having the lowest SHBG concentration and African-American and white men having the highest mean concentrations. Increasing levels of BMI positively, but slightly, influenced free estradiol. A larger proportion of free estradiol levels were related to free testosterone (positively) and SHBG (negatively) levels. Men with the highest free testosterone and lowest SHBG levels had free estradiol levels approxi-mately 3-fold higher than those with the lowest free testosterone and highest SHBG concentrations. The relationships between free testosterone and free estradiol, and between SHBG and estradiol, were linear. The concentrations of SHBG were slightly higher with greater age, were positively related to total testosterone levels, and were negatively associated with free estradiol levels. The rate of decline in free testosterone in older men is about 10% per decade. Higher SHBG levels were related to lower estradiol levels independent of free testosterone, suggesting that either SHBG has effects on estradiol levels over and above its testosterone-binding properties or that SHBG is actually a surrogate for other variables that may affect both SHBG and estradiol levels.” [7]
Another study showed total testosterone of elderly men were inversely associated with weight, BMI, waist to hip ratio, systolic and diastolic blood pressure, fasting plasma glucose and/or serum insulin, HOMA-IR, triglycerides, CRP and leptin levels and positively related to HDL cholesterol and adiponectin levels. Total testosterone was slightly lower among men who consumed at least one alcohol drink daily, compared with those who drank less or not at all. Those who maintained a healthy BMI/LBM index maintained higher levels of total testosterone. The risk of death was significantly elevated for men in the lowest quartile of the total and bioavailable(free) testosterone distributions. Low total and bioavailable testosterone were each significantly associated with elevated 20-years decline period risk of Cardio Vascular Disease mortality and death due to respiratory disease but not from cancer or death due to other fatal causes. Renal, liver disease, stroke and pulmonary disease have also been linked to low total and free testosterone in older men. [8]
Now both these articles conclude that it would be REALLY BENEFICIAL to take TRT (testosterone replacement therapy) if suffering from hypogonadism; which is primarily found in older men. Men who suffer from low testosterone do not get to reap the fruits of life as much as those who have higher levels of testosterone. Lots of older men use Testosterone replacement therapy to increase Rapid Eye Movement (REM) sleep in order to recover efficiently. There are studies that show that older men use testosterone replacement treatment for a better sense well of being. There are countless studies that show the distinct relationship between depression and testosterone levels. Depression and anxiety lead to lower levels of total and free testosterone, which would explain why certain SSRI’s have a noticeable effect on testosterone levels, serotonin along other neurotransmitters have been linked to effecting hormonal output. The one issue that some older men have with TRT is the higher increments in hemoglobin and hematocrit than young men after adjusting for testosterone levels. When older men take solid doses of testosterone studies show that they lose fat real quickly along with added muscle mass. These traits can be attributed to the ANABOLIC EFFECTS OF TESTOSTERONE! When men are receiving injections of testosterone; automatically nitrogen retention and protein synthesis capabilities rise much higher than the norm. This allows the individual the ability to consume more protein making anabolism even easier. Of course as age heightens; libido drops and old men lose the will or desire to engage in sexual activity. Testosterone also improves HDL which helps cholesterol in return providing proper blood flow to the corpus cavernosum allowing MAXIMUM erection strength. Testosterone replacement therapy has been touted to prevent osteoporosis through increasing the bone mineral density, when testosterone has a good ratio with estrogen it provides a nice sturdy foundation for bone structure, which again re-establishes the importance of testosterone to the male body. Older men as well as young men both deserve to enjoy the benefits of testosterone whether it is through endogenous or exogenous means.
Sleep really does Testosterone some Good!
Sleep really does Testosterone some Good!
Recent research suggests that testosterone plays a role in regulating the CNS during sleep and vice versa. When sleeping in particularly during Rapid Eye Movement; testosterone levels raise dramatically, however as one awakes and encounters the typical stressors, testosterone levels gradually fall throughout the waking day. Rapid Eye Movement occurs in intervals of 90 minutes per stage of sleep, so if one were to sleep 8 hours, the individual could go through REM about 6 times throughout their sleep. Sleep deprivation results in a collection of widespread symptoms leading to alterations in catecholamine, hormone levels, and behaviors. In particular, sleep loss has been connected with altered regulation of the hypothalamic-pituitary adrenal axis, and it impairs gonadal function by producing a marked reduction in testosterone concentration. Subnormal testosterone concentrations may contribute to sexual inadequacy in humans, which may affect established or desired sexual relations. Sleep deprivation really negatively impacts over trained athletes, so those who compete as an athlete NEED to sleep in order for their body to maximize its hormonal production. When sleep is interrupted, the rise of testosterone is also interrupted causing a sudden drop, again REM is EXTREMLY important for the rise of testosterone during sleep. The endocrine system (specifically TESTOSTERONE) has a responsibility to maintain the metabolic processes needed for tissue repair, regeneration, and recovery. The circulating testosterone levels also are play a role in erection frequency, as time goes erection during REM lessens, which would also would explain the correlation of testosterone with libido. Sleep deprivation can lead to many sleep disorders, one common one is linked to testosterone, and this disorder is Sleep Apnea. Sleep Apneic males with severe breathing issues exhibited delayed peak testosterone concentrations. Men with severe obstructive sleep apnea show significantly reduced serum concentrations of free and total testosterone and of sex hormone-binding globulin (SHBG), though their LH levels are normal. This endocrine defect was reversed after 3 months of continuous positive airway pressure (CPAP) therapy. Males who take artificial amounts of testosterone also may have issues with sleep disturbances. Testosterone raises the nocturnal metabolic rate which can negatively affect the way one sleeps. Again realize these are people on cycle and not people with normal amounts of testosterone. Basically low or TOO high levels of testosterone can negate REM sleep which is why one should get blood work done to see where they stand. Many studies show that sleep deprivation leads higher cortisol levels and lower total/free testosterone levels, so I tell you all SLEEP AND SLEEP WELL! Higher testosterone leads to better sleep and more frequencies of REM. [4]
For anyone needing help getting to sleep and staying a sleep at night Need2sleep is the perfect sleep aid Need 2 Sleep . Not only will it help get you to sleep faster but it helps get you into a deep sleep and keeps you there longer.
Testosterone good for the Brain!
Unlike what people may have thought due to the common “MeatHead” nickname given to muscular dumb guys, testosterone increases neurological function. An article I came across showed that as a result of decline in age, testosterone dropped, this led to increased risks for Alzheimer’s disease. Men with Alzheimer’s disease had lower levels of serum testosterone; this explains how both testosterone and estrogen have neuro-stimulative properties. Since Testosterone and Estrogen are neurosteroids this means they would also help prevent one from easily acquiring Addison’s disease. I even saw some research on PubMed that displayed testosterone’s importance in preventing Dementia, another “Slowing down of the Brain” disease. This is why dopamine in abundance has a positive effect on testosterone, although too much dopamine can cause over-stimulation leading to Schizophrenia. Some of you may be saying what he means by “neuro-stimulation”. When one ingests 200mg of caffeine, they are ingesting a bunch of stimulants which cause your neurotransmitters to rapidly fire, well certain sex hormones like testosterone act in this matter without the jittery feeling. This effect allows for better awareness, mental clarity, mental acuity, increased memory and so on. Caffeine has been proven to be effective in improving cognitive function, this goes to show you that when you compare caffeine to testosterone in the way they effect the brain, they both positive since they delay the effects of Dementia while allowing you to do more mental tasks
So far we have seen that testosterone is good for the heart, respiratory system, brain function, blood glucose levels, cholesterol, bone density, sense of well being, and now we see testosterone’s anabolic properties. Here is a full abstract from another article that shows the anabolic benefits of testosterone:
“Testosterone Therapy Prevents Gain in Visceral Adipose Tissue and Loss of Skeletal Muscle in Nonobese Aging Men
C. A. Allan, B. J. G. Strauss, H. G. Burger, E. A. Forbes and R. I. McLachlan
Prince Henry’s Institute (C.A.A., H.G.B., E.A.F., R.I.M.), Andrology Australia (C.A.A., R.I.M.), and Departments of Obstetrics and Gynecology (C.A.A., R.I.M.) and Medicine (B.J.G.S.), Monash University; and Clinical Nutrition and Metabolism Unit (B.J.G.S.), Monash Medical Centre, Monash University, Clayton, Victoria 3168, Australia
Address all correspondence and requests for reprints to: Professor R. I. McLachlan, Prince Henry’s Institute, P.O. Box 5152, Clayton, Victoria 3168, Australia. E-mail:
[email protected] .
Background: Trials of testosterone therapy in aging men have demonstrated increases in fat-free mass (FFM) and skeletal muscle and decreases in fat mass (FM) but have not reported the impact of baseline body composition.
Objective: The objective of the study was to determine the effect, in nonobese aging men with symptoms of androgen deficiency and low-normal serum testosterone levels, of testosterone therapy on total and regional body composition and hormonal and metabolic indices.
Methods: Sixty healthy but symptomatic, nonobese men aged 55 yr or older with total testosterone (TT) levels less than 15 nM were randomized to transdermal testosterone patches or placebo for 52 wk. Body composition, by dual-energy x-ray absorptiometry (FM, FFM, skeletal muscle) and magnetic resonance imaging (abdominal sc and visceral adipose tissue, thigh skeletal muscle, and intermuscular fat) and hormonal and metabolic parameters were measured at wk 0 and 52.
Results: Serum TT increased by 30% (P = 0.01), and LH decreased by 50% (P < 0.001). Relative to placebo, total body FFM (P = 0.03) and skeletal muscle (P = 0.008) were increased and thigh skeletal muscle loss was prevented (P = 0.045) with testosterone therapy and visceral fat accumulation decreased (P = 0.001) without change in total body or abdominal sc FM; change in visceral fat was correlated with change in TT levels (r2 = 0.36; P = 0.014). There was a trend to increasing total and low-density lipoprotein cholesterol with placebo.
Conclusion: Testosterone therapy, relative to placebo, selectively lessened visceral fat accumulation without change in total body FM and increased total body FFM and total body and thigh skeletal muscle mass”.
PCT
now you guys can see that PCT (Post Cycle Therapy) is crucial to maintain gains and boost overall health. Many studies and blood panels have shown that PCT boosts liver cells, better ALT/LST levels, good cholesterol, proper testosterone to estrogen ratios, proper testosterone to cortisol ratios, solid IGF levels, proper hypothalamus function, proper brain function, good adrenals, good sense of well being, anti-oxidative, anti-cancerous, restoration of distorted blood vessels, proper maintenance of SHBG’s, bone and ligament/joint protection. As you can see there is plenty of reasons to have a PCT aligned besides maintaining gains. I have always been a firm believer of keeping testosterone and FREE testosterone levels up in order to keep vitality and overall quality of life. There are many way PCT protocols once could follow, I suggest do your own research and see what fits you best. Before/after a cycle and post PCT one should follow their body by doing hormonal/organ blood work to see where you stand.
Supplements to boost testosterone naturally!
For years people have tried many ways to boost testosterone naturally for their specific means of interest. We had the tribulus error which was proven not to do much for the human male. Studies recently suggest that tribulus does boost androgen receptors within the brain which causes the rise in libido associated with supplementation of it. Now AI’s have been proven to raise LH output, increase both total and FREE testosterone while lowering estrogen. Formestane, 6bromo, Exemestane, arimadex all do the job in boosting total/free testosterone while blocking estrogen. 6-bromo and Formestane also block prolactin which allows for even MORE TOTA/FREE TESTOSTERONE boost. It is able to block prolactin by blocking the progesterone receptors at the same time it blocks the estrogen receptors. This would make Formestane an IDEAL otc AI while on Deca to avoid the unwanted “deca-dick”. The benefits of Formestane are really undeniable and should be a part of everyone’s artillery. Formestane also boosts IGF levels which mean MORE MUSCLE GROWTH. Formestane can be used as a standalone, on cycle and during PCT! I did not mention ATD why, simple it has anti-androgen properties since it blocks the androgen receptor in the brain which leads to a lack of libido. It also does not boost testosterone levels as once thought, it appears that ATD provides false testosterone levels because ATD contains metabolites similar to Testosterone which cause the false high positives. Currently there are three reliable sources of Formestane:
1. Competitive Edge Labs Formestane
2. Formestane LV
3.
https://www.mrsupps.com/Product-Forma-Stanzol_26.aspx
In this article: BCAAs raise T levels in bodybuilders
We get to see how effective BCAA’s are in boosting testosterone since they reduce cortisol levels which rise during intense training. People have tried to deny the effectiveness of BCAA’s but as you can see it boosts testosterone. It only took 6 grams of BCAA’s for 4 weeks to see a noticeable difference. Now imagine taking the effects of Gear (Bovine super plasma blood serum) which is 3x more potent than standard BCAA’s, this means MORE TESTOSTERONE boost and MORE MUSCLE PRESERVATION! More testosterone leads to gains in MUSCLE MASS, STRENGTH, RECOVERY, and a BETTER YOU!
HCGenerate brings a revolution to all herbal testosterone boosters because it contains a specific extract of Fadogia. Fadogia has shown to increase total testosterone levels at 6x more than that of some of the other popular herbal raws. It helps preserve and create new leydig cells which allows for more conversion of cholesterol to testosterone. Its ability to boost LH and testosterone dramatically makes it very comparable to HCG, which is why HCGenerate can be used on cycle to minimize shutdown; allowing PCT to be a breeze. HCGenerate also contains testofen which has been shown to DOUBLE FREE testosterone levels in HUMAN males. Free testosterone means that one is able to achieve the anabolic and androgenic effects of testosterone. When testosterone is not free; its USELESS because it cannot be used for any masculine purpose. So if one has really high testosterone but low free testosterone; they will not really reap the benefits that someone on a cycle of testosterone will receive. HCGenrate also contains Divanil which boosts FREE testosterone, lowers SHBG levels and boosts Nitric Oxide levels. HCGenerate is a MUST if you plan on using a SERM( Selective Estrogen Receptor Modulator) because SERM’s have been proven to raise SHBG’s which will drop free (useable) testosterone. Eventually high SHBG’s leads to not only low Free testosterone but Low total testosterone as seen with older individuals.
7,8 Benzoflavone has always intrigued me because of its effectiveness. There are studies that show boosts testosterone by increasing GrRH release in which it stimulates GABAergic modulation and at the same time blocks estrogen due to its AI properties. It has an IC50 value of 70nm which is RIDICULOUS for an herbal raw, this explains why individuals who use this raw have dramatic boosts in testosterone with low LH levels. This raw converts LH to testosterone at a high rate while keep estrogen to a norm; giving it a nice 1-2 punch. I have seen my testosterone levels with bloodwork boost over 50% which is definitely impressive and lets me know it’s a must to add in my PCT with HCGenerate. Forma-stanzol again has what you need and contains 7,8 benzoflavone.
https://www.mrsupps.com/Product-Forma-Stanzol_26.aspx
Forged Steel has really caught my eye as of recently since it boosts libido DRAMATICALLY and boosts testosterone at the same time! Let’s start off with the pumpkin seed powder that Forged Steel contains. Pumpkin seed powder has an abundance of Zinc which is crucial for maintaining testosterone efficiency, along bone density strength. Zinc protects the prostate from prostate enlargement which can be fatal. Zinc also is important for fertility in providing more counts of semen and semen mobility. Solid levels of Zinc also prevent testosterone from converting to DHT at a high rate which is what you want. Pumpkin Powder Seed has also been touted to raise FEMALE’S LIBIDO through her olfactory system. In essence, the scent of pumpkin makes a woman wetter in her “special place” which is what any testosterone filled dude wants! Companies are now starting to make colognes with Pumpkin seed powder extract to entice men to purchase their product. So it’s real simple, ingesting pumpkin seed leads to a concentration of pumpkin seed in the body, which leads to pore concentration, finally translates to women appeal and a good chance of GETTING LAID! Forged Steel also contains Muira Puama which decreases prolactin leading to increased TOTAL testosterone levels. It also boosts dopamine levels which lead to HARDER ERECTIONS and LASTING LONGER in the bedroom! Forged Steel is the REAL DEAL if you are looking for a quick boost prior to sexual activity.
FORGED STEEL - OrbitNutrition
One more raw I want you all to witness is mytosterone, this bad boy has been proven to boost testosterone by 60% while blocking estrogen by 9% and blocking DHT conversion by 20 plus %. Here is an excerpt to the study that showcases mytosterone:
“BACKGROUND: Maintaining endogenous testosterone (T) levels as men age may slow the symptoms of sarcopenia, andropause and decline in physical performance. Drugs inhibiting the enzyme 5alpha-reductase (5AR) produce increased blood levels of T and decreased levels of dihydrotestosterone (DHT). However, symptoms of gynecomastia have been reported due to the aromatase (AER) enzyme converting excess T to estradiol (ES). The carotenoid astaxanthin (AX) from Haematococcus pluvialis, Saw Palmetto berry lipid extract (SPLE) from Serenoa repens and the precise combination of these dietary supplements, Alphastat(R) (Mytosterone(trade mark)), have been reported to have inhibitory effects on both 5AR and AER in-vitro. Concomitant regulation of both enzymes in-vivo would cause DHT and ES blood levels to decrease and T levels to increase. The purpose of this clinical study was to determine if patented Alphastat(R) (Mytosterone(trade mark)) could produce these effects in a dose dependent manner. METHODS: To investigate this clinically, 42 healthy males ages 37 to 70 years were divided into two groups of twenty-one and dosed with either 800 mg/day or 2000 mg/day of Alphastat(R) (Mytosterone(trade mark)) for fourteen days. Blood samples were collected on days 0, 3, 7 and 14 and assayed for T, DHT and ES. Body weight and blood pressure data were collected prior to blood collection. One-way, repeated measures analysis of variance (ANOVA-RM) was performed at a significance level of alpha = 0.05 to determine differences from baseline within each group. Two-way analysis of variance (ANOVA-2) was performed after baseline subtraction, at a significance level of alpha = 0.05 to determine differences between dose groups. Results are expressed as means +/- SEM. RESULTS: ANOVA-RM showed significant within group increases in serum total T and significant decreases in serum DHT from baseline in both dose groups at a significance level of alpha = 0.05. Significant decreases in serum ES are reported for the 2000 mg/day dose group and not the 800 mg/day dose group. Significant within group effects were confirmed using ANOVA-2 analyses after baseline subtraction. ANOVA-2 analyses also showed no significant difference between dose groups with regard to the increase of T or the decrease of DHT. It did show a significant dose dependant decrease in serum ES levels. CONCLUSION: Both dose groups showed significant (p = 0.05) increases in T and decreases in DHT within three days of treatment with Alphastat(R) (Mytosterone(trade mark)). Between group statistical analysis showed no significant (p = 0.05) difference, indicating the effect was not dose dependent and that 800 mg/per day is equally effective as 2000 mg/day for increasing T and lowering DHT. Blood levels of ES however, decreased significantly (p = 0.05) in the 2000 mg/day dose group but not in the 800 mg/day dose group indicating a dose dependant decrease in E levels.”
Myodrol 120 caps, Axis Labs - OrbitNutrition
Pretty impressive huh, I think a stack of Myodrol, HCGenerate and forma-stanzol would be INSANE providing that one will SIGNIFIGANTLY boost total/free testosterone, lower conversion of testosterone to DHT and estradiol, and preventing high aromatization. The only supplement that has a legit dose of mytosterone is myodrol by Axis Labs: Myodrol 120 caps, Axis Labs - OrbitNutrition
Be it just to feel naturally more like a man or to help feel less like a woman during pct, Testosterone is what separates the men from the boys my friends and now you know how to get you some.
Sources:
1.Journal of Clinical Endocrinology & Metabolism Vol. 37, No. 1 148-151
doi:10.1210/jcem-37-1-148
2. Michael R. Waterman, Genes Involved in Androgen Biosynthesis and the Male PhenotypeDiane S. KeeneyDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tenn., USA Vol. 38, No. 5-6, 1992
3.Steroid Hormones
4. Monica Levy Andersen*, Sergio Tufik. The effects of testosteroneonsleep and sleepdisorderedbreathing in men:Its bidirectionalinteraction with erectile function. Sleep Medicine Reviews (2008) 12, 365e379 (
http://www.sono.org.br/pdf/2008_Ande...ep_Med_Rev.pdf)
5. ABDULAMAGED M. TRAISH, ANDRE GUAY, FARID SAAD. The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance. Journal of Andrology, Vol. 30, No. 1, January/February 2009. (The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance -- Traish et al. 30 (1): 23 -- Journal of Andrology)
6. Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2006;295: 1288 –1299.[
7. Testosterone and Estradiol among Older Men. The Journal of Clinical Endocrinology & Metabolism Vol. 91, No. 4 1336-1344
Testosterone and Estradiol among Older Men -- Orwoll et al. 91 (4): 1336 -- Journal of Clinical Endocrinology & Metabolism
8. Low Serum Testosterone and Mortality in Older Men. The Journal of Clinical Endocrinology & Metabolism Vol. 93, No. 1 68-75(2008)
Low Serum Testosterone and Mortality in Older Men -- Laughlin et al. 93 (1): 68 -- Journal of Clinical Endocrinology & Metabolism
9. Older Men Are as Responsive as Young Men to the Anabolic Effects of Graded Doses of Testosterone on the Skeletal Muscle. The Journal of Clinical Endocrinology & Metabolism Vol. 90, No. 2 678-688 (2005)
10. Jones, T.H. (Barnsley/Sheffield) (eds): Advances in the Management of Testosterone Deficiency. Testosterone, Bone and Osteoporosis Front Horm Res. Basel, Karger, 2009, vol 37, pp 123-132 (2010)
11. NEJM -- The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men
12.Age-Related Testosterone Depletion and the Development of Alzheimer Disease. Vol.292 Nov.12, Sept. 22-29, 2004
13. Behav Brain Res. 2010 Jan 20; 206(2): 216-22.
14.Inhibition of human estrogen synthetase (aromatase) by flavones JT Kellis, Jr et al.Science, Sep 1984; 225: 1032 - 1034.
15. Pumpkin Seeds Shown to Boost Sex Drive
16. An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. Journal of the International Society of Sports Nutrition 2008, 5:12 (2008)
17. orbitnutrition.com
18. mrsupps.com
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