I was asking about supplementation, there are plenty of waise through diet and exercise. Strictly supplements.
Testofen which is popular now because of Phyto-Test, show improvement of 98% if Free Test. From the GenCor Human Study.
LongJax by AIDP taken from website...
As the key male hormone, testosterone is well known for its role in reproductive health. Fewer people are aware of its essential role in cardiovascular health, cognitive function, insulin sensitivity and the maintenance of lean body mass and bone density. At around age 30, testosterone levels begin a gradual decline that continues throughout the life span.[10] In part, this is due to increased production of sex hormone-binding globulin (sex hormone binding globulin ), a protein that binds testosterone, making it biologically unavailable. This can result in a condition known as low testosterone syndrome, or andropause. Low testosterone syndrome is associated with reduced sexual function, increased risk of cardiovascular disease, reduced insulin sensitivity, cognitive decline, mood changes and bone loss.[11] Lean body mass may gradually be replaced with fat, culminating in sarcopenia, an age-related condition characterized by the twin markers of obesity and diminished muscular strength.[12]
One specific extract, LongJaX™, was administered to human subjects in two separate studies. In first study, 800 mg/day of LongJaX™ showed testosterone increasing within two days, and doubling in five.[13] The second longer-term study showed 400 mg/day increased testosterone over 30% at 21 days, and over 50% by day 50.[14]
LJ100
How does it work?
Tongkat Ali root contains numerous beneficial compounds and potent protective antioxidants which inhibit cellular aging. Our recent human clinical trials has shown LJ100® to increase IGF1 level and modulate Cortisol level. The bioactive Eurypeptides® significantly boost sex drive and function, in both men and women, by increasing testosterone and inhibiting Sex Hormone Binding Globulin (sex hormone binding globulin ), so that more free testosterone remains in the blood. This additionally stems the aging process, improves energy and sexual function, and helps to reduce risk factors associated with hypertension and cardiovascular disease. In vitro study shows that LJ100® is not only capable in increasing the testosterone production but at the same time it also influences the synthesis of which plays an important role in communication, psychological , pheromone- An a and sexual behavior both in human and animals.
Our scientists, Dr Johari Saad, Phd found that when given LJ100®, testosterone levels in animals increase by 3 to 4 times. In laboratory test on human testicular tissue, LJ100® increases the formation of testosterone fourfold. In men, testosterone plays a key role in the development and maturity of male sex organs, sexual desire and sexual behavior. In women, testosterone is the key to sex drive and essential to pleasure.
Human clinical research conducted by Dr Ismail Tambi, from the Specialist Reproduction Research Center in Malaysia have confirmed that LJ100® increases serum testosterone level, increases DHEA level, and decreases SHBG level considerably. When given 100 mg of LJ100® for 3 weeks, 91% of the subjects reported improvement in libido, 73% improvement in sexual function, and 82% psychological improvement relative to sex among the men participated in the study.
WATER – SOLUBLE EXTRACT OF LJ100 ® AS A POTENTIAL NATURAL ENERGIZER FOR HEALTHY AGING MEN
by M.I.M. TAMBI, S. OTHMAN AND J.M. SAAD
SHIQ results showed 62% of the cases having an increased or maximum score. Breakdown of the results showed increase in sexual desire and success in the attempts at sexual intercourse while on treatment and related well with the PADAM score’s results showing improvement in sexual attempts and desire. PADAM score demonstrated that 82% of the cases showed a decrease in total score. The breakdown included: 91% improvement of sexual component, 73% improvement in the physical component, and 82% improvement of the psychological component. The Vasomotor score showed improvement in 52% of the subjects. Analysis of DHEA showed gradual increase in the level from 26% after 1 week to 47% after 3 weeks. This suggests that the extract may influence the DHEA production, which would in turn subsequently be aromatized to testosterone. SHBG analysis showed that levels were reduced in 36% of the cases after one week. The reduction went up to 66% after 3 weeks. This suggests that the extract could have an effect on the production of SHBG. Consequently, when SHBG level declines, the Free Testosterone Index (FTI) goes up. FTI analysis showed an escalation of 39% of subjects after 1 week and 73% after 3 weeks.
THE ANABOLIC EFFECTS OF LJ100 ® Sareena Hanim Hamzah & Ashril Yusof
Fat free mass of the group supplemented with LJ100 Eurycoma water soluble extract showed a significant increment of approximately 2.1 kg. There were no significant changes in fat free mass in placebo. Body fat percentage were significantly decreased in treatment and placebo. However, a greater decrement was shown in treatment compared to placebo i.e. 9.14% and 6.57% respectively. The 1 RM test muscle strength test showed an increase in gross muscle power in both groups. The treatment group showed a greater increment in strength compared to placebo i.e. 6.78% and 2.77% respectively. The mean arm circumference in treatment group increased significantly by 1.8 cm following the supplementation while no significant changes observed in placebo group. The mean sEMG reading of the treatment and placebo showed a significant decrement in values after going through the exercise program. However, the treatment group showed 2.92% higher reduction in electrical activity of the muscle measured at the end of the experiment period compared to placebo (25.70% and 22.78% respectively). During and after the administration of Eurycoma, no adverse effects were noted within the treatment group.
LJ100 ® Saliva Testosterone Test
Saliva Testosterone Test of 9 Individuals 26-52 years of Age
¢ Dosage 2x2(50mg/capsules) morning & evening for 10 days
¢ Normal range for athlete 800 = 150ng/dl of blood
Volunteer
age
pre treatment
ng/dl blood
after treatment
ng/dl blood Increase
%
1
26
860 = 30
1,650 = 50
91.86%
2
28
580 = 30
985 = 35
69.83%
3
35
875 = 40
1, 576 = 60
80.11%
4
24
950 = 45
2,210 = 55
132.63%
5
29
755 = 30
1,345 = 35
78.15%
6
48
650 = 20
875 = 30
34.62%
7
52
450 = 25
765 = 35
70.00%
8
50
585 = 25
875 = 35
49.57%
9
42
350 = 30
480 = 35
37.14%
Data – preliminary data - more work to be carried out
Volunteers 1-5 are athletes - data are an average of 3 different studies at different times
Volunteers 6-9 do not exercise on a regular basis
2005 Human Clinical
20 male volunteers of various health conditions from the ages of 38 to 58 were randomly given either 200,400,600 mg of LJ100 (22% Bioactive Eurypeptides) or placebo for 2 months. The SHIM (Sexual Health Inventory for Male) scores were elevated to upper normal level showing improvement in sexual desire and performance for majority of the volunteers. The Aging Male Score (AMS) were lowered showing improvement in sexual, physical, psychology, and vasomotor domain for majority of the volunteers. Testosterone and DHEAS levels showed high normal levels when compared to baseline and is consistent with the excellent QOL (Quality of Life) score. LJ100 modulates the production of DHEAS, which would in turn be aromatized to testosterone. Bioavailable testosterone is needed to maintain wellness and enhance libido.
Full blood examinations showed normal limits even at 600mg dosage for all tests. LJ100 does not interfere with the platelets or hemoglobin and does not have any toxicity to the RBC. The liver function test showed no liver toxicity even at high doses of LJ100 . Renal function test showed that LJ100 has no harmful effect on the renal system even for men whose renal function is affected (as seen in the diabetics). Some volunteers even showed improved or normal levels of uric acid at end of trials. Tumor markers are sensitive indicators of cellular stress. AFP( Alpha Fetal Protein) identifies testicular cancer; PSA ( Prostate Specific Antigen) is used to detect prostate cancer. All tumor markers were within normal levels even at 600mg dosage of LJ100 .
The Lipid studies showed increment of high-density lipoprotein (HDL Cholesterol –good cholesterol) levels. Elevations of HDL are normally associated with a lower risk of heart attack.
Volunteers who were diabetic, showed significant effect on lowering the blood glucose levels. LJ100 does not exert hypoglycemic effects but may have influence on the cellular uptake of glucose.
The cortisol levels were in the higher normal level for the LJ100 group as opposed to the placebo group. T
High thyroxin indicates high BMR (Basal Body Metabolism Rate). Majority of volunteers on LJ100 have high normal level of thyroxine compared to the placebo group. This mean slight higher metabolism rate which can be translated to better weight management. Volunteers taking LJ100 have high normal level of IGF-1 at end of trials. Some with low IGF-1 level was increased to normal level after 1 week. Placebo group is showing no change in the IGF-1 levels. This study suggests that LJ100 has a secretagogue effect on growth hormone and modulates the release of IGF-1; in turn, making it a great anti-aging supplement.
Effect of LJ100 on Anabolic Balance During Endurance Exercise
Talbott S, Talbott J, Negrete J, Jones M, Nichols M, and Roza J.
SupplementWatch, Inc. Draper, UT & Source One Global Partners, Chicago, IL
Published: Journal of International Society of Sport Medicine 3 (1): S32 2006
Eurycoma Longifolia, commonly known as "Tongkat Ali" or "Longjack", is often touted as a testosterone "booster" and marketed to athletes as a training aid and performance enhancer. Rodent studies have shown oral delivery of Eurycoma extract to improve sexual performance and increase serum testosterone levels. Open-label human trials have suggested that Eurycoma extract may help prevent age-associated androgen defieciency, improve sexual function, and increase psychological parameters such as mood, ebergy, and sense of well-being. The purpose of this study was to determine the effects of Eurycoma Longiflia on testosterone and cortisol levels during intense endurance exercise.
Methods
We used a freeze dried extract of Eurycoma Longifolia (E) standardized to 22% EuryPeptides and 40% Glycosaponins. Male subjects (N=30) were recruited from a 24-hour mountain biking event and asked to provide a saliva sample before and after each lap for measurement of cortisol and testosterone by enzyme immunoassay (Salimetrics, State College, PA.) Subjects completed 4 laps (14.91 miles / lap) and provided 8 saliva samples over a 24 hour period. Subjects consumed 100mg of E (N = 15) or a look-alike placebo (P, N = 15) approximately 30 minutes prior to exercise.
Results
Cortisol levels were 32.3% lower in E compared to P (0.552+0.665 versus 0.816+0.775 ug/dL, P < 0.05). Testosterone levels were 16.4% higher in E compared to P (86.72+40.90 versus 72.47+33.77 pg/mL, P < 0.05).
LJ100 vs. LongJax 20:1
LJ100 is a Eurycoma product that is a 100:1 water extract. They recently have standardized their product based on Europeptide. They had a patent application filed on that. I have read carefully the patent application (US 2004/0087493). I am not convinced that the peptide they identified, 36 amino acids, 4.3KD is responsible for the biological activity for the following reason:
A) The only biological test they did in the patent application was using a Fr3 fraction by size-exclusive column. This faction contains many things, among them the 36 amino acids, 4.3KD peptide. Based on my many year’s experience in drug-based screening, unless you purify the peptide or synthesis the peptide and use it for the biological testing, you can not conclude at all that the peptide is responsible for the effect. IN fact, 98% of the cases it is not responsible.
Based on my experience, peptide normally elute at 20-40 mins range. 9 mins elute is too early for peptide, which makes me skeptical.
C) If you look at the HPLC graph on Figure 3 of the patent application, there are many different components there. Unless they specifically tested the peptide (which did not show in the patent), they can not conclude that the peptide is responsible for the biological effect.
Unless they have direct data, Europeptide is misleading to me.
2) Lab Analysis
If they believe that it is the glycoprotein that is responsible, our product has high content of glycoprotein, even at a 20:1 ratio. Here is the result of our LongJax versus LJ 100 done at the same independent lab:
Based on the Glycoprotein level, our product provides 10 fold more value compared to LJ100 since their product is 5 times more concentrated. This is conceivable because optimal extraction concentration will likely retain more useful ingredients.
3) Human Studies:
The optimum test of the biological function is, of course, the effectiveness in human. We have also carried a small human test, and fortunately, used the same method as done by LJ100. Thus it can be used as a comparison.
1) LJ100 study (copied from Website)
Saliva Testosterone Test of 9 Individuals 26-52 years of Age
¢Dosage 2x2(50mg/capsules) morning & evening for 10 days
¢Normal range for athlete 800 = 150ng/dl of blood
Volunteer age pre treatment after treatment %
ng/dl blood ng/dl blood Increase
1 26 860 = 30 1,650 = 50 91.86%
2 28 580 = 30 985 = 35 69.83%
3 35 875 = 40 1, 576 = 60 80.11%
4 24 950 = 45 2,210 = 55 132.63%
5 29 755 = 30 1,345 = 35 78.15%
6 48 650 = 20 875 = 30 34.62%
7 52 450 = 25 765 = 35 70.00%
8 50 585 = 25 875 = 35 49.57%
9 42 350 = 30 480 = 35 37.14%
Data – preliminary data - more work to be carried out
Volunteers 1-5 are athletes - data are an average of 3 different studies at different times
Volunteers 6-9 do not exercise on a regular basis
2) Longjax study
Testosterone Saliva Test
(Dosage 800mg/day for 5 days)
Volunteer Age Pre-treatment After-treatment % increase
(ng/dl) (ng/dl)
_________________________________________________________
1 61 49.9 130.9 150%
2 40 147 274 86%
3 25 181 334 85%
_________________________________________________________
*Tests were done in the US by medical clinical labs.
*Samples were collected same time every morning.
*Preliminary data
* Volunteers do not exercise on a regular basis.
Notice that in normal individuals, LJ100 at 200mg/day (100:1 extract) increased T on an average 47.83% in four individuals. Longjax, on the other hand, increased T on an average 107% in three individuals at a dosage of 800mg/day (20:1 extract). Thus, LongJax is 2-fold effective in human tests even at a lower dosage as compared to LJ100.
4) Safety Issue:
Longjax has a LD50 of greater than 5g/kg (the highest people normally test). We spent more money to have the test done in Japan to insure quality.
5) Other Quality Advantages of Longjax
A. We set internal quality control standards. We take steps to make sure our quality is consistent. B. We do studies in the US to assure accuracy.
C. LongJaX is reprocessed in the US. As a result, it offers the following three advantages.
a) Free flowing and friendly for manufacturing.
The eurycoma extract tends to be clumpy when stored over a period of time. The capsule may not look the same as the new ones. LongJaX can store much longer without the same issue. Your capsules can maintain its original form over time.
c) The eurycoma extract can have high yeast and mould. The reprocessing process will help control yeast and mould.
d).Our material is made of roots. There are inferior materials on the market that are made of trunk. Such extract may have low potency and high toxic ingredients.
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