Niacin

[Mysterio]

When you take Niacin do you ever get all ichy and hot? It's really uncomfortable! Anyways, why does this occur?

 

[Mysterio]

So no one knows why I get this reaction?

 

[YellowJacket]

I do too bro, id say it probably has something to do with the blood in your body. Niacin raises vascularity and that always makes me itch when my blood is flowing like that

 

[naturally anabolic]

it opens up all the blood vessels in your body, that feeling you are getting is caused by that.

 

[willy]

I think it has to do with histamines?

 

[Mysterio]

Thanks guys!

 

[cockdezl]

Niacin causes the release of prostaglandin D2 from the tissue beds of causing a capillary dilation.

Title

Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid.
Author
Morrow JD; Parsons WG 3d; Roberts LJ 2d
Address
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232.
Source
Prostaglandins, 1989 Aug, 38:2, 263-74
Abstract
Nicotinic acid (niacin) is a B vitamin which is also a potent hypolipidemic agent. However, intense flushing occurs following ingestion of pharmacologic doses of niacin which greatly limits its usefulness in treating hyperlipidemias. Previous studies have demonstrated that niacin-induced flushing can be substantially attenuated by pre-treatment with cyclooxygenase inhibitors, suggesting that the vasodilation is mediated by a prostaglandin. However, the prostaglandin that presumably mediates the flush has not been conclusively determined. In this study we report the finding that ingestion of niacin evokes the release of markedly increased quantities of PGD2 in vivo in humans. PGD2 release was assessed by quantification of the PGD2 metabolite, 9 alpha, 11 beta-PGF2, in plasma by gas chromatography mass spectrometry. Following ingestion of 500 mg of niacin in three normal volunteers, intense flushing occurred and plasma levels of 9 alpha, 11 beta-PGF2 were found to increase dramatically by 800, 430, and 535-fold. Levels of 9 alpha, 11 beta-PGF2 reached a maximum between 12 and 45 min. after ingesting niacin and subsequently declined to near normal levels by 2-4 hours. Levels of 9 alpha, 11 beta-PGF2 in plasma correlated with the intensity and duration of flushing that occurred in the 3 volunteers. Release of PGD2 was not accompanied by a release of histamine which was assessed by quantification of plasma levels of the histamine metabolite, N tau-methylhistamine. This suggests that the origin of the PGD2 release is not the mast cell. Only a modest increase (approximately 2-fold) in the urinary excretion of the prostacyclin metabolite, 2,3-dinor-6-keto-PGF1 alpha, occurred following ingestion of niacin and no increase in the excretion of the major urinary metabolite of PGE2 was found. These results indicate that the major vasodilatory PG released following ingestion of niacin is PGD2. The fact that markedly increased quantities of PGD2 are released suggests that PGD2 is the mediator of niacin-induced vasodilation in humans.

 

[Magnússon]

Get the flush free capsules. I sometimes consume 500 mg before I lift to get some freaky ass veins poppin out, the fina helps just a bit too

 

[Nutri-Wrestler]

whats wrong with a niacin flush? niacin is used to get you veiny im guessing.

Ross

 

[Mysterio]

whats wrong with a niacin flush? niacin is used to get you veiny im guessing.

Ross [/QUOTE

I burns like a MOTHER!