Please Scroll Down to See Forums Below 
.jpg "Research Chemical Sciences")
.png "Research Chemical Sciences")
needtogetaas
New member
Joint pain is a all to common problem among Americans. Even more so among body builders and people who work out. repetitive motion,pore bone health and nutrition,over working, over training,over weight,stress,and more. The list goes on and on.
A joint may consist of the following components:
• Cartilage - at the joint, the bones are covered with cartilage (a connective tissue), which is made up of cells and fibers and is wear-resistant. Cartilage helps reduce the friction of movement.
• Synovial membrane - a tissue called the synovial membrane lines the joint and seals it into a joint capsule. The synovial membrane secretes synovial fluid (a clear, sticky fluid) around the joint to lubricate it.
• Ligaments - strong ligaments (tough, elastic bands of connective tissue) surround the joint to give support and limit the joint's movement.
• Tendons - tendons (another type of tough connective tissue) on each side of a joint attach to muscles that control movement of the joint.
• Bursas - fluid-filled sacs, called bursas, between bones, ligaments, or other adjacent structures help cushion the friction in a joint.
• Synovial fluid - a clear, sticky fluid secreted by the synovial membrane.
• Femur - the thigh bone
• Tibia - the shin bone
• Patella - the knee-cap
• Meniscus - a curved part of cartilage in the knees and other joints
Problems with any part of the joint can cause pain. From bone health to proper Synovial fluid secretion each part of the body plays a significant role in how your joints stay pain free or leave you in agony during day to day activity.
In this Article I will be explaining how the (Needtobuildmuscle Pain relief stack) can restore health and proper function to problem areas ie muscles,joints,and bones.As well as Give immediate, constant, and long term pain relief to joints and muscles.
The (needtobuildmuscle pain relief stack) consist of two powerful cutting edge products. Both products use many medically proven ingredients, Combined with well known Holistic health ingredient to get the job done from the inside out and outside in. Yes, The stack is a two prong pain relief and prevention combo.
Staring from the inside out. Our first product in the stack Forged joint repair uses pharmaceutical grade glucosamine and chondroitin as well as Turmeric, Boswellia serrata extract,Quercetin,and Cissus quadrangularis to do a number of things with in the body (More on this later)
From the outside in. The second product in our stack (Skeletal-balm) uses a powerful all natural but time tested and proven topical delivery system. With its powerful topical delivery system Skeletal-balm deliverers Pure Cosmetic Grade ingredients instantly deep threw the skin into the bones and joints. Giving not only immediate But constant, and long term joint pain and muscle pain relief.
Lets first look at (Forged joint aid) effects on joint pain and bone health.
The first two ingredients pharmaceutical grade glucosamine and chondroitin. There have been a lot of joint products on the market ever since chondroitin and glucosamine first became available. Some work, some don't. What we at Needtobuildmuscle have noticed separates these two categories is quality. So when it came time for us to release a joint repair
formula we knew we had to start with the highest quality pharmaceutical grade glucosamine and chondroitin we could find. Know the company you are dealing with and the quality of the products they produce. Needtobuildmuscle.com is fast becoming a trusted name in the supplements industry, and for good reason. We use only the best and have a 100% money back standard we live by each day.
glucosamine
Effects on Cartilage
Firstly healthy cartilage needs three things: water for lubrication and nourishment, proteoglycans to attract and hold the water, and collagen to keep the proteoglycans in place.
Proteoglycans are like a rope that threads itself through the collage and are essential as they hold many times their own weight of water, which both lubricates and nourishes the collagen. If the cartilage is damaged the thread of rope becomes weak and ‘leaks’ out and thus the collagen loses its nourishment as the proteoglycans lose their grip and float away. Thus the cartilage cannot withstand shocks, cracks and may wear out completely.
Glucosamine is a major building block of the water – loving proteoglycans. Besides being a building block for the synthesis of proteoglycans, its mere presence acts as a stimulus to the cells that produce proteoglycans – in fact glucosamine is a key factor in determining how many proteoglycans are produced by the cells.
Glucosamine has been shown to speed up production of both proteoglycans and collagen and it normalises cartilage metabolism which helps keep cartilage from breaking down.
Thus because of the affect of glucosamine on cartilage metabolism it can in fact help the body to repair damaged or eroded cartilage. In other words, glucosamine strengthens your body’s natural repair mechanisms.
Besides stimulating cartilage production, glucosamine also reduces joint pain and inflammation
CHRONDROITON
Where glucosamine helps form the proteoglycans that sit within the space in the cartilage, chrondroiton sulphate acts like ‘liquid magnets’. Chrondroiton is a long chain of repeating nigans that attracts fluid into the proteoglycan molecules.
This is important for two reasons:
the fluid acts as a spongy shock absorber
the fluid sweeps the nutrients into the cartilage. Joint cartilage has no blood supply thus all of its nourishment and lubrication comes from the fluid that ebbs and flows as pressure is applied and released to the joint. Without this fluid, cartilage would become malnourished, drier, thinner and more fragile.
Chrondoiton Sulphate is a long chain molecule with a negative charge attached to it. As these chains wrap around proteoglycans they repel each other and thus create spaces between each proteoglycan. These are what are known as matrixes within the cartilage and this is where the fluid flows. There may be as many as 10,000 of these chains on a single proteoglycan molecule – thus we have a super water retainer as these chains make sure all these molecules are away from each other and cannot clump together.
Besides drawing in precious fluid, chrondroiton :
protects cartilage and stops it from breaking down and inhibits certain ‘cartilage chewing’ enzymes interferes with the metabolism of other enzymes that will starve the cartilage of fluid stimulates production of proteoglycans, glucosamine and collagen.
“Our joints are surrounded by a membrane called the synovial membrane (or synovium), which forms a capsule around the ends of the bones involved. This membrane secretes a liquid called the synovial fluid. It has many functions, all of them important. Among these, it serves as a lubricant, a shock absorber and a nutrient carrier. As a lubricant, it is without equal, when the joint is healthy. It makes the joint slicker than wet ice!
“When our bodies can’t produce enough glucosamine and chondroitin, however, the normally thick synovial fluid becomes thin and watery. In this state, it can’t do the job it was intended to do as a lubricant. As a shock absorber, our cartilage, immersed in the synovial fluid, protects our bones from the tremendous impact they would receive when we walk, run, jump, etc.
“This fluid also has remarkable properties as a shock absorbing, or hydraulic, fluid. It belongs to a rather unusual group of liquids known as dilatent liquids. These liquids are characterized by the rare quality of becoming thicker, that is, more viscous, when shear is applied to them.
“Thus, the synovial fluid in our knees and hips assume a very viscous nature at the moment of shear in order to protect the joints, and then it thins out again to its normal viscosity instantaneously to resume its lubricating function between shocks. All this happens over and over again, very rapidly, during the course of vigorous exercise, such as during an engagement in sports, dancing, walking, etc.
“When our bodies can’t produce enough glucosamine and chondroitin, this whole mechanism breaks down. The viscosity is dramatically reduced, giving thin, watery synovial fluid, which then fails as the shock absorber and lubricant it normally excels at.
“This results in the pain, stiffness and decreased mobility.
Inflamation of the joints is the main culprit for a lot of pain. For this reason We packed Forged joint repair full of natural Anti inflammatory herbs and plant flavonoids.
Boswellia serrata extract
Many studies have proven Boswellia serrata anti inflammatory effects.
Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFα, IL-1β, NO and MAP kinase
Abstract
The aim of the present study is to probe the anti-inflammatory potential of the plant Boswellia serrata by studying the effect of the crude extract and the pure compound isolated from it on key inflammatory mediators like TNFα, IL-1β, and NO thus enabling the understanding of the key signaling events involved. The crude methanolic extract and the pure compound were analysed for their inhibitory effect on TNFα, IL-1β and IL-6. The results demonstrated that all three cytokines are down regulated when PBMCs are cultured in the presence of crude extract or the pure compound at various time points. Observations on Th1/Th2 cytokines revealed marked down regulation of Th1 cytokines IFNγ and IL-12 while the Th2 cytokines IL-4 and IL-10 were up regulated upon treatment with crude extract and pure compound. The extract and the pure compound isolated also showed considerable inhibition of NO production in activated RAW 264.7 cells, possibly via suppression of inducible NO synthase mRNA expression. Further to elucidate the underlying mechanism of action the effect of 12-ursene 2-diketone on LPS-induced activation of MAPK has also been examined. Our results demonstrated that 12-ursene 2-diketone inhibits the expression of pro-inflammatory cytokines and mediators via inhibition of phosphorylation of the MAP kinases JNK and p38 while no inhibition was seen in ERK phosphorylation in LPS-stimulated PBMCs. The above study therefore indicates that the crude methanolic extract and the isolated pure compound are capable of carrying out a natural anti-inflammatory activity at sites where chronic inflammation is present by switching off the pro-inflammatory cytokines and mediators, which initiate the process.
Animal studies performed in India showed ingestion of a defatted alcoholic extract of Boswellia decreased polymorphonuclear leukocyte infiltration and migration, decreased primary antibody synthesis and caused almost total inhibition of the classical complement pathway. In an in vitro study of the effects of ß-Boswellic acid on the complement system,the extract demonstrated a marked inhibitory effect on both the classical and alternate complement systems.
In vitro testing revealed Boswellia in a dose-dependent manner, blocks the synthesis of pro-inflammatory 5-lipoxygenase products, including 5- hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4), which cause bronchoconstriction, chemotaxis, and increased vascular permeability. A recent in vivo study examined Boswellia extract and ketoprofen for their effects on glycosaminoglycan metabolism. Boswellia significantly reduced the degradation of glycosaminoglycans compared to controls, whereas ketoprofen caused a reduction in total tissue glycosaminoglycan content
Research has identified specific active anti-inflammatory
ingredients in this herb, which are commonly referred to as boswellic acids. In
animal studies, these acids have been shown to reduce inflammation significantly
in several ways. Boswellic acids deter inflammatory white cells from
infiltrating damaged tissue. They improve blood flow to the joints. They also
block chemical reactions that set the stage for inflammation to occur in chronic
intestinal disorders such as Crohn’s disease and ulcerative colitis. Boswellia
may help to ease symptoms of osteoarthritis and rheumatoid arthritis. Boswellia
can be taken internally as well as applied topically to affected joints to
relieve inflammation associated with these joint disorders. This may lessen
morning stiffness and increase joint mobility.
In a study of 175 patients with rheumatic disorders such as rheumatoid
arthritis, 122 participants experienced reduced stiffness and inflammation two
to four weeks after starting on a boswellia regimen. Boswellia’s
anti-inflammatory properties can help to reduce aching and stiffness, especially
when associated with low back pain. Although research indicates that boswellia
is best taken orally for this purpose, creams appear to be soothing as well.
Boswellia also appears to reduce the inflammation associated with ulcerative
colitis and Crohn’s disease, both painful intestinal disorders. It seems to
accomplish this without the risk of further gut irritation associated with many
conventional pain relievers. In a 1997 study of ulcerative colitis sufferers,
82% of those who took boswellia extract (350 mg three times daily) experienced a
complete remission of their disease
Turmeric
Most people know turmeric as a culinary herb (it's the spice in curry powder that makes it yellow), but it also possesses potent medicinal properties. A member of the ginger family, turmeric (Curcuma longa) treats mild osteoarthritis pain and inflammation. Only animal studies have proven its ability to reduce joint inflammation, but the herb has a centuries-long history of being used for inflammation in Ayurveda, the traditional medical system of India. plain and simple turmeric can effectively relieve joint pain.
Doctors and researchers are unsure exactly how turmeric works, although it appears to inhibit the production of inflammatory chemicals called prostaglandins and leukotrienes. A 1997 study in Molecular and Cellular Biochemistry showed that turmeric along with capsaicin (from red pepper) lowered inflammation in rats' paws. Other studies have been done on inflammation not related to joints; one of the studies involved rats, and another involved surgery patients with post-operative inflammation. Both the studies showed that turmeric reduced inflammation as powerfully as the drug phenylbutazone
plant flavonoid Quercetin
Effect of the flavonoid quercetin on inflammation ...[J Gastroenterol. 2008] - PubMed Result
SpringerLink - Journal Article
As anyone who has had to take
ibuprofen or another NSAID for joint disease or injury knows, an anti-inflammatory does more than
pain relief. It prevents further injury to the joint from the body's own immune system. In addition
quercetin is a powerful anti-oxidant.
Cissus quadrangularis effects on bone health and other cool goodies.
Cissus has a large vitamin component but more importantly the ability to deliver the vitamin to the target tissue.Cissus also stimulates myoblast and osteoblast acitivity. Form my brief studies on Tendons, Osteoblasts and myoblasts stimulate collagen II synthesis. Just because we stimulate collagen II synthesis does not exactly correlate to HEALING of an injury. You can stimulate Collagen II synthesis and GROW NEW tissue. New tissue is great if its directly stimulated where injury occurs. You can stimulate new growth but the growth may be away from the injury. A great example is your brick wall has a whole in it and instead of patching the whole directly you build a NEW wall to over the whole. The structural instability is still present.
Cissus in research has proven to correct structural instability in fractures. The healing process of Fractures includes Tendon and ligament stability.
THE SCIENCE
Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of Ceylon and India. It was prescribed in the ancient Ayurvedic texts as a general tonic and analgesic, with specific bone fracture healing properties. Modern research has shed light on Cissus' ability to speed bone healing by showing it acts as a glucocorticoid antagonist (1,2). Since anabolic/androgenic compounds are well known to act as antagonists to the glucocorticoid receptor as well as promote bone growth and fracture healing, it has been postulated that Cissus possesses anabolic and/or androgenic properties (1,3). In addition to speeding the remodeling process of the healing bone, Cissus also leads to a much faster increase in bone tensile strength. In clinical trials Cissus has led to a fracture healing time on the order of 55 to 33 percent of that of controls. That cissus exerts antiglucocorticoid properties is suggested by a number of studies where bones were weakend by treatment with cortisol, and upon administration of Cissus extract the cortisol induced weakening was halted, and the healing process begun.
While the increased rate of bone healing may be of great significance to persons suffering from chronic diseases like osteoporosis (4), the antiglucocorticoid properties of Cissus are likely of much more interest to the average bodybuilder or athlete, since endogenous glucocorticoids, particularly cortisol, are not only catabolic to bone, but catabolize muscle tissue as well. Numerous studies over the years have suggested that glucorticoids, including the body's endogenous hormone cortisol activate pathways that degrade not only bone, but skeletal muscle tissue as well. A recently published report documented exactly how glucocorticoids (including cortisol) induce muscle breakdown: They activate the so-called ubiquitin-proteasome pathway of proteolysis (5). This pathway of tissue breakdown is important for removing damaged and non-functional proteins. However, when it is overactive during periods of elevated cortisol (e.g disease states, stress, and over-training) excess amounts of normal tissue are broken down as well. By exerting an anabolic, antiglucorticoid effect cissus helps preserve muscle tissue during times of physical and emotional stress.
Although the bulk of the research on Cissus centers around bone healing, the possibility exists that Cissus may act to improve bone healing it may improve the healing rate of connective tissue in general, including tendons. If this is the case it would be of great benefit to bodybuilders and athletes.
Besides the above-mentioned properties of Cissus, the plant is also rich in the vitamins/antioxidants vitamin C and beta-carotene. As analyzed, Cissus quadrangularis contained ascorbic acid 479 mg, and carotene 267 units per 100g of freshly prepared paste in addition to calcium oxalate (6).
The typical recommended daily dosage of Cissus is 3 to 6 gramalso s to accelerate fracture healing. Safety studies in rats showed no toxic effects at dosages as high as 2000 mg/kg of body weight. So not only is Cissus efficacious, it is quite safe, in either the dried powder form or the commercially available extract.
Cissus also possess analgesic properties on a mg per mg basis comparable to aspirin or anti-inflammatory drugs like ibuprofen. Cissus quadrangularis, which has been proved to be highly effective in relieving pain, reduction of swelling and promoting the process of healing of the simple fractures as well as in curing the allied disorders associated with fractures (7). The mechanism through which Cissus exerts its analgesic and anti-inflammatory properties has not been well characterized. It may act centrally, but the anti-inflammatory features suggest that it acts by preventing the conversion of arachidonic acid to inflammatory prostaglandins.
Real World Application for injuries
Simply if your suffering from Joint pain, Ligament pain, cartilage pain, had surgery on bone, ligament or cartilage, Cissus is the supplement to use.
Some users will get instant relief and other will need to use Cissus for much longer period of time for complete healing of an injury.
THE OTHER SIDE EFFECT IS ANABOLIC!
Cissus is anabolic and anti-catabolic!!! Cissus users report a "PUMP" that we call the Cissus pump. The PUMP effect becomes prevalent at approximately 10-15 days of continous Cissus use. The "PUMP" is due to the increase of blood flow to the muscle. The Cissus pump will have you flexing your muscle for no apparent reason. This is when you know the product has exerted its effect.
This is a topic I will discus In depth in other Articles.
Now that we have covered how the (needtobuildmuscle pain relief stack) can be effective from the inside out. Le us now look into how it works from the outside in. Using our Super powerful Skeletal-balm
Skeletal-balm
A unique combination of natural nutrients formulated to relieve arthritis pain, muscle stiffness, soreness and to provide improved joint and muscle flexibility.
Using a powerful topical delivery system Skeletal-balm relieves pain and repairs joint and bone health.
The first and most powerful Ingredent in Skeletal-balm is Emu Oil
. Emu oil is a natural transdermal.
SpringerLink - Journal Article
Emu Oil Institute - Emu Oil Research
Research Proves Emu Oil Claims Valid
Our Skeletal-balm a Topically applied Joint and Muscle Reliever lotion is rich in Emu Oil, a transdermal anti-inflammatory and anti microbial. Comprised of concentrated Omega 3 fatty acids, Emu Oil naturally penetrates quickly and deeply carry effective nutrient, minerals and proteins to sore, inflammed muscles and joints.
Emu Oil Speeds cell regeneration and is naturally healing moisturizing and lubricating. It also acts as a transdermal carrier that has the ability to bring therapeutic ingredients deep into the skin. In addition, Emu Oil naturally contains a high level of Linoleic acid, a substance know to ease muscle and joint pain and Oleic acid, which provides a local anti-inflammatory effect.
Combining Emu oil and other other essential oils We have created a topical delivery system to deliver Methylsulfonylmethane (MSM) and other ingredents deep into the bone.
Topical Methylsulfonylmethane (MSM)
he potential benefits of MSM are extensive. MSM is an organic form of sulphur, the 3rd most vital nutrient in our body. In fact, sulphur is so essential to life that it is found everywhere, in every cell in every plant and animal on the planet. And, although it is available in foods we eat: meats, poultry, fish, eggs, dairy, most of it is lost in the processing, so supplementation with a reliable product could be potentially, extremely beneficial.
Most of us have heard of MSM's benefits in reducing or eliminating muscle soreness and cramps in aging patients and in athletes. It is well known that combined with the regenerative capabilities of glucosamine and chondroitin, MSM is proving to be a substantial player in the treatment of arthritis and other degenerative joint diseases. This powerful trio is now recognized as pivotal to any anti-arthritic regimen.
MSM's role as a molecular transporter is fascinating. It moves important nutrients to damaged cartilage and tissues, aiding in the control of the degeneration and pain of arthritis. The very small MSM molecules can pass easily through the skin and most tissues, enabling them to bind and escort sulfur atoms to their appropriate functional sites. Because of the many proteins, catalysts and enzymes which require a sulphur component in order to perform their specific jobs, a continual supply of sulphur must be provided to insure the 'normalizing' of these physiologic activities.
MSM (Methyl Sulfonyl Methane) was isolated by Robert Herschler and Dr. Stanley Jacob of the University of Oregon Medical School in the early 80's. Their research showed that MSM is a natural sulfur compound found in all living things. It revealed that MSM one of the most prominent compounds in our bodies, just behind water and sodium. In his research, Dr. Jacob found that the sulfur in MSM, called Sulfonyl, is as safe and is as important as vitamin C in our diet. He observed that it is very different than the bad sulfurs like sulfite, often used to preserve certain foods. MSM is a member of the sulfur family but should never be confused with sulfa drugs, to which some people are allergic. MSM is a natural form of organic sulfur found in all living organisms, including human body fluids and tissues. MSM originates in the ocean and reaches the human food chain through rainfall. MSM is an odorless, water-soluble, white crystalline material that supplies a bio-available form of dietary sulfur. While MSM is normally found in many common foods, including raw milk, meat, fish and a variety of fruits, vegetables, and grains, it is normally lost from our food by heating, storage, processing, drying, cooking and preserving and even washing. MSM has been shown to add flexibility to cell walls while allowing fluids to pass through the tissue more easily. MSM enhances tissue pliability and encourages the repair of damaged skin(6) MSM levels in humans decline with age, resulting in symptoms of fatigue, tissue and organ malfunction, and increased susceptibility to disease(6).
In a study of 24 people with athletic injuries, MSM was shown to reduce symptoms by nearly twice as much as those taking placebos, and was able to reduce the average needed visits to the chiropractor by approximately 60%(7). Another preliminary study compared 10 degenerative arthritis suffers taking MSM versus 6 who took a placebo. Results indicate a better than 80 percent control of pain within six weeks for those patients using MSM, while only two patients showed a minimal improvement (less than 20 percent) on the placebo(7). Dr. Lawrence, the medical doctor who headed up these studies, relates that he has treated more than one thousand patients with MSM and believes that it is safer than water. He noted that it appears that the body uses what it requires and flushes out the rest within 12 hours. According to a recent book by Lawrence, Jacob, and Zucker, entitled The Miracle of MSM, MSM can be a natural remedy for osteoarthritis, rheumatoid arthritis, Fibromyalgia, tendonitis and bursitis, muscular soreness and athletic injuries, carpal tunnel syndrome, post-traumatic inflammation and pain, heartburn and hyperacidity, headaches and back pain, and allergies. It was also noted that people taking MSM may notice other benefits, including softer skin, harder nails, thicker hair, and softening of scar tissue. An allotted time of 2 - 4 weeks may be needed before significant improvement is seen When using oral MSM but much faster when using topical.
Topical MSM is much faster and more powerful then Oral.
Skeletal-balm Uses Peppermint to help promote blood flow and reduce pain on contact. Acting as a natural Heating agent peppermint has been shown to reduce swelling,and relieve pain in most users.
Skeletal-balm Also has Aromatherapy Joint Pain Relief effects.
peppermint stimulates both hot and cold reactions in nerve endings in the skin. The brain registers these sensations at the same time. The contrast between the two messages makes a liniment seem much hotter than it really is.
muscle-relaxing and inflammation-reducing essential oils such as rosemary, marjoram, and lavender Then penetrate into the skin to work directly on the muscle giving a combined instant sensatory effect That relieves pain on contact.
Shea Butter
Several studies have shown shea butter to contain super effective anti-inflammatory compounds called triterpenes
The Shea Butter triterpenes are unique because they also stop inflammation throughout the body. In fact, research has shown that these are the most powerful inflammation fighter of any known botanical in the world. This is extremely important because pain is caused by inflammation so it is important to stop it is important to reduce inflammation as much as possible to remain pain free.
In addition to all its other amazing qualities, Shea Butter contains triterpene butyrospermol, a fat that penetrates deep into the skin. This is coupled with the presence of stigmasterol, a sterol known for its draining and anti-inflammatory properties
ALOE VERA - Provides healing, moisturizing, antiseptic, analgesic and anti-inflammatory properties. It’s natural penetrating action supplies moisture directly to tissues and stimulates the growth of healthy tissues. This is because Aloe Vera contains three natural analgesics for pain relief: magnesium, lupeol and salicylic acid. It also contains three natural anti-inflammatory agents for swelling, heat, redness and pain. This is why Aloe Vera is so effective for burns, cuts, scrapes and abrasions, as well as rheumatoid arthritis.These wonderful ingredients make “O” Shea J.A.M. a highly effective treatment for the temporary relief of: joint pain and stiffness, joint inflammation, back, hip, knee and arthritis pain, muscle pain, sore muscles, sprains, carpal tunnel syndrome.
Needtobuildmuscle.inc uses nothing but the most powerful pharmaceutical And cosmetic grade ingredients. Our customers satisfaction means everything to us. We pride our selfs on using the best,being the best and having the best.
Get the best joint aid,bone health,pain reliever stack on the market today at needtobuildmuscle.com For a affordable price.
A joint may consist of the following components:
• Cartilage - at the joint, the bones are covered with cartilage (a connective tissue), which is made up of cells and fibers and is wear-resistant. Cartilage helps reduce the friction of movement.
• Synovial membrane - a tissue called the synovial membrane lines the joint and seals it into a joint capsule. The synovial membrane secretes synovial fluid (a clear, sticky fluid) around the joint to lubricate it.
• Ligaments - strong ligaments (tough, elastic bands of connective tissue) surround the joint to give support and limit the joint's movement.
• Tendons - tendons (another type of tough connective tissue) on each side of a joint attach to muscles that control movement of the joint.
• Bursas - fluid-filled sacs, called bursas, between bones, ligaments, or other adjacent structures help cushion the friction in a joint.
• Synovial fluid - a clear, sticky fluid secreted by the synovial membrane.
• Femur - the thigh bone
• Tibia - the shin bone
• Patella - the knee-cap
• Meniscus - a curved part of cartilage in the knees and other joints
Problems with any part of the joint can cause pain. From bone health to proper Synovial fluid secretion each part of the body plays a significant role in how your joints stay pain free or leave you in agony during day to day activity.
In this Article I will be explaining how the (Needtobuildmuscle Pain relief stack) can restore health and proper function to problem areas ie muscles,joints,and bones.As well as Give immediate, constant, and long term pain relief to joints and muscles.
The (needtobuildmuscle pain relief stack) consist of two powerful cutting edge products. Both products use many medically proven ingredients, Combined with well known Holistic health ingredient to get the job done from the inside out and outside in. Yes, The stack is a two prong pain relief and prevention combo.
Staring from the inside out. Our first product in the stack Forged joint repair uses pharmaceutical grade glucosamine and chondroitin as well as Turmeric, Boswellia serrata extract,Quercetin,and Cissus quadrangularis to do a number of things with in the body (More on this later)
From the outside in. The second product in our stack (Skeletal-balm) uses a powerful all natural but time tested and proven topical delivery system. With its powerful topical delivery system Skeletal-balm deliverers Pure Cosmetic Grade ingredients instantly deep threw the skin into the bones and joints. Giving not only immediate But constant, and long term joint pain and muscle pain relief.
Lets first look at (Forged joint aid) effects on joint pain and bone health.
The first two ingredients pharmaceutical grade glucosamine and chondroitin. There have been a lot of joint products on the market ever since chondroitin and glucosamine first became available. Some work, some don't. What we at Needtobuildmuscle have noticed separates these two categories is quality. So when it came time for us to release a joint repair
formula we knew we had to start with the highest quality pharmaceutical grade glucosamine and chondroitin we could find. Know the company you are dealing with and the quality of the products they produce. Needtobuildmuscle.com is fast becoming a trusted name in the supplements industry, and for good reason. We use only the best and have a 100% money back standard we live by each day.
glucosamine
Effects on Cartilage
Firstly healthy cartilage needs three things: water for lubrication and nourishment, proteoglycans to attract and hold the water, and collagen to keep the proteoglycans in place.
Proteoglycans are like a rope that threads itself through the collage and are essential as they hold many times their own weight of water, which both lubricates and nourishes the collagen. If the cartilage is damaged the thread of rope becomes weak and ‘leaks’ out and thus the collagen loses its nourishment as the proteoglycans lose their grip and float away. Thus the cartilage cannot withstand shocks, cracks and may wear out completely.
Glucosamine is a major building block of the water – loving proteoglycans. Besides being a building block for the synthesis of proteoglycans, its mere presence acts as a stimulus to the cells that produce proteoglycans – in fact glucosamine is a key factor in determining how many proteoglycans are produced by the cells.
Glucosamine has been shown to speed up production of both proteoglycans and collagen and it normalises cartilage metabolism which helps keep cartilage from breaking down.
Thus because of the affect of glucosamine on cartilage metabolism it can in fact help the body to repair damaged or eroded cartilage. In other words, glucosamine strengthens your body’s natural repair mechanisms.
Besides stimulating cartilage production, glucosamine also reduces joint pain and inflammation
CHRONDROITON
Where glucosamine helps form the proteoglycans that sit within the space in the cartilage, chrondroiton sulphate acts like ‘liquid magnets’. Chrondroiton is a long chain of repeating nigans that attracts fluid into the proteoglycan molecules.
This is important for two reasons:
the fluid acts as a spongy shock absorber
the fluid sweeps the nutrients into the cartilage. Joint cartilage has no blood supply thus all of its nourishment and lubrication comes from the fluid that ebbs and flows as pressure is applied and released to the joint. Without this fluid, cartilage would become malnourished, drier, thinner and more fragile.
Chrondoiton Sulphate is a long chain molecule with a negative charge attached to it. As these chains wrap around proteoglycans they repel each other and thus create spaces between each proteoglycan. These are what are known as matrixes within the cartilage and this is where the fluid flows. There may be as many as 10,000 of these chains on a single proteoglycan molecule – thus we have a super water retainer as these chains make sure all these molecules are away from each other and cannot clump together.
Besides drawing in precious fluid, chrondroiton :
protects cartilage and stops it from breaking down and inhibits certain ‘cartilage chewing’ enzymes interferes with the metabolism of other enzymes that will starve the cartilage of fluid stimulates production of proteoglycans, glucosamine and collagen.
“Our joints are surrounded by a membrane called the synovial membrane (or synovium), which forms a capsule around the ends of the bones involved. This membrane secretes a liquid called the synovial fluid. It has many functions, all of them important. Among these, it serves as a lubricant, a shock absorber and a nutrient carrier. As a lubricant, it is without equal, when the joint is healthy. It makes the joint slicker than wet ice!
“When our bodies can’t produce enough glucosamine and chondroitin, however, the normally thick synovial fluid becomes thin and watery. In this state, it can’t do the job it was intended to do as a lubricant. As a shock absorber, our cartilage, immersed in the synovial fluid, protects our bones from the tremendous impact they would receive when we walk, run, jump, etc.
“This fluid also has remarkable properties as a shock absorbing, or hydraulic, fluid. It belongs to a rather unusual group of liquids known as dilatent liquids. These liquids are characterized by the rare quality of becoming thicker, that is, more viscous, when shear is applied to them.
“Thus, the synovial fluid in our knees and hips assume a very viscous nature at the moment of shear in order to protect the joints, and then it thins out again to its normal viscosity instantaneously to resume its lubricating function between shocks. All this happens over and over again, very rapidly, during the course of vigorous exercise, such as during an engagement in sports, dancing, walking, etc.
“When our bodies can’t produce enough glucosamine and chondroitin, this whole mechanism breaks down. The viscosity is dramatically reduced, giving thin, watery synovial fluid, which then fails as the shock absorber and lubricant it normally excels at.
“This results in the pain, stiffness and decreased mobility.
Inflamation of the joints is the main culprit for a lot of pain. For this reason We packed Forged joint repair full of natural Anti inflammatory herbs and plant flavonoids.
Boswellia serrata extract
Many studies have proven Boswellia serrata anti inflammatory effects.
Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFα, IL-1β, NO and MAP kinase
Abstract
The aim of the present study is to probe the anti-inflammatory potential of the plant Boswellia serrata by studying the effect of the crude extract and the pure compound isolated from it on key inflammatory mediators like TNFα, IL-1β, and NO thus enabling the understanding of the key signaling events involved. The crude methanolic extract and the pure compound were analysed for their inhibitory effect on TNFα, IL-1β and IL-6. The results demonstrated that all three cytokines are down regulated when PBMCs are cultured in the presence of crude extract or the pure compound at various time points. Observations on Th1/Th2 cytokines revealed marked down regulation of Th1 cytokines IFNγ and IL-12 while the Th2 cytokines IL-4 and IL-10 were up regulated upon treatment with crude extract and pure compound. The extract and the pure compound isolated also showed considerable inhibition of NO production in activated RAW 264.7 cells, possibly via suppression of inducible NO synthase mRNA expression. Further to elucidate the underlying mechanism of action the effect of 12-ursene 2-diketone on LPS-induced activation of MAPK has also been examined. Our results demonstrated that 12-ursene 2-diketone inhibits the expression of pro-inflammatory cytokines and mediators via inhibition of phosphorylation of the MAP kinases JNK and p38 while no inhibition was seen in ERK phosphorylation in LPS-stimulated PBMCs. The above study therefore indicates that the crude methanolic extract and the isolated pure compound are capable of carrying out a natural anti-inflammatory activity at sites where chronic inflammation is present by switching off the pro-inflammatory cytokines and mediators, which initiate the process.
Animal studies performed in India showed ingestion of a defatted alcoholic extract of Boswellia decreased polymorphonuclear leukocyte infiltration and migration, decreased primary antibody synthesis and caused almost total inhibition of the classical complement pathway. In an in vitro study of the effects of ß-Boswellic acid on the complement system,the extract demonstrated a marked inhibitory effect on both the classical and alternate complement systems.
In vitro testing revealed Boswellia in a dose-dependent manner, blocks the synthesis of pro-inflammatory 5-lipoxygenase products, including 5- hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4), which cause bronchoconstriction, chemotaxis, and increased vascular permeability. A recent in vivo study examined Boswellia extract and ketoprofen for their effects on glycosaminoglycan metabolism. Boswellia significantly reduced the degradation of glycosaminoglycans compared to controls, whereas ketoprofen caused a reduction in total tissue glycosaminoglycan content
Research has identified specific active anti-inflammatory
ingredients in this herb, which are commonly referred to as boswellic acids. In
animal studies, these acids have been shown to reduce inflammation significantly
in several ways. Boswellic acids deter inflammatory white cells from
infiltrating damaged tissue. They improve blood flow to the joints. They also
block chemical reactions that set the stage for inflammation to occur in chronic
intestinal disorders such as Crohn’s disease and ulcerative colitis. Boswellia
may help to ease symptoms of osteoarthritis and rheumatoid arthritis. Boswellia
can be taken internally as well as applied topically to affected joints to
relieve inflammation associated with these joint disorders. This may lessen
morning stiffness and increase joint mobility.
In a study of 175 patients with rheumatic disorders such as rheumatoid
arthritis, 122 participants experienced reduced stiffness and inflammation two
to four weeks after starting on a boswellia regimen. Boswellia’s
anti-inflammatory properties can help to reduce aching and stiffness, especially
when associated with low back pain. Although research indicates that boswellia
is best taken orally for this purpose, creams appear to be soothing as well.
Boswellia also appears to reduce the inflammation associated with ulcerative
colitis and Crohn’s disease, both painful intestinal disorders. It seems to
accomplish this without the risk of further gut irritation associated with many
conventional pain relievers. In a 1997 study of ulcerative colitis sufferers,
82% of those who took boswellia extract (350 mg three times daily) experienced a
complete remission of their disease
Turmeric
Most people know turmeric as a culinary herb (it's the spice in curry powder that makes it yellow), but it also possesses potent medicinal properties. A member of the ginger family, turmeric (Curcuma longa) treats mild osteoarthritis pain and inflammation. Only animal studies have proven its ability to reduce joint inflammation, but the herb has a centuries-long history of being used for inflammation in Ayurveda, the traditional medical system of India. plain and simple turmeric can effectively relieve joint pain.
Doctors and researchers are unsure exactly how turmeric works, although it appears to inhibit the production of inflammatory chemicals called prostaglandins and leukotrienes. A 1997 study in Molecular and Cellular Biochemistry showed that turmeric along with capsaicin (from red pepper) lowered inflammation in rats' paws. Other studies have been done on inflammation not related to joints; one of the studies involved rats, and another involved surgery patients with post-operative inflammation. Both the studies showed that turmeric reduced inflammation as powerfully as the drug phenylbutazone
plant flavonoid Quercetin
Effect of the flavonoid quercetin on inflammation ...[J Gastroenterol. 2008] - PubMed Result
SpringerLink - Journal Article
As anyone who has had to take
ibuprofen or another NSAID for joint disease or injury knows, an anti-inflammatory does more than
pain relief. It prevents further injury to the joint from the body's own immune system. In addition
quercetin is a powerful anti-oxidant.
Cissus quadrangularis effects on bone health and other cool goodies.
Cissus has a large vitamin component but more importantly the ability to deliver the vitamin to the target tissue.Cissus also stimulates myoblast and osteoblast acitivity. Form my brief studies on Tendons, Osteoblasts and myoblasts stimulate collagen II synthesis. Just because we stimulate collagen II synthesis does not exactly correlate to HEALING of an injury. You can stimulate Collagen II synthesis and GROW NEW tissue. New tissue is great if its directly stimulated where injury occurs. You can stimulate new growth but the growth may be away from the injury. A great example is your brick wall has a whole in it and instead of patching the whole directly you build a NEW wall to over the whole. The structural instability is still present.
Cissus in research has proven to correct structural instability in fractures. The healing process of Fractures includes Tendon and ligament stability.
THE SCIENCE
Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of Ceylon and India. It was prescribed in the ancient Ayurvedic texts as a general tonic and analgesic, with specific bone fracture healing properties. Modern research has shed light on Cissus' ability to speed bone healing by showing it acts as a glucocorticoid antagonist (1,2). Since anabolic/androgenic compounds are well known to act as antagonists to the glucocorticoid receptor as well as promote bone growth and fracture healing, it has been postulated that Cissus possesses anabolic and/or androgenic properties (1,3). In addition to speeding the remodeling process of the healing bone, Cissus also leads to a much faster increase in bone tensile strength. In clinical trials Cissus has led to a fracture healing time on the order of 55 to 33 percent of that of controls. That cissus exerts antiglucocorticoid properties is suggested by a number of studies where bones were weakend by treatment with cortisol, and upon administration of Cissus extract the cortisol induced weakening was halted, and the healing process begun.
While the increased rate of bone healing may be of great significance to persons suffering from chronic diseases like osteoporosis (4), the antiglucocorticoid properties of Cissus are likely of much more interest to the average bodybuilder or athlete, since endogenous glucocorticoids, particularly cortisol, are not only catabolic to bone, but catabolize muscle tissue as well. Numerous studies over the years have suggested that glucorticoids, including the body's endogenous hormone cortisol activate pathways that degrade not only bone, but skeletal muscle tissue as well. A recently published report documented exactly how glucocorticoids (including cortisol) induce muscle breakdown: They activate the so-called ubiquitin-proteasome pathway of proteolysis (5). This pathway of tissue breakdown is important for removing damaged and non-functional proteins. However, when it is overactive during periods of elevated cortisol (e.g disease states, stress, and over-training) excess amounts of normal tissue are broken down as well. By exerting an anabolic, antiglucorticoid effect cissus helps preserve muscle tissue during times of physical and emotional stress.
Although the bulk of the research on Cissus centers around bone healing, the possibility exists that Cissus may act to improve bone healing it may improve the healing rate of connective tissue in general, including tendons. If this is the case it would be of great benefit to bodybuilders and athletes.
Besides the above-mentioned properties of Cissus, the plant is also rich in the vitamins/antioxidants vitamin C and beta-carotene. As analyzed, Cissus quadrangularis contained ascorbic acid 479 mg, and carotene 267 units per 100g of freshly prepared paste in addition to calcium oxalate (6).
The typical recommended daily dosage of Cissus is 3 to 6 gramalso s to accelerate fracture healing. Safety studies in rats showed no toxic effects at dosages as high as 2000 mg/kg of body weight. So not only is Cissus efficacious, it is quite safe, in either the dried powder form or the commercially available extract.
Cissus also possess analgesic properties on a mg per mg basis comparable to aspirin or anti-inflammatory drugs like ibuprofen. Cissus quadrangularis, which has been proved to be highly effective in relieving pain, reduction of swelling and promoting the process of healing of the simple fractures as well as in curing the allied disorders associated with fractures (7). The mechanism through which Cissus exerts its analgesic and anti-inflammatory properties has not been well characterized. It may act centrally, but the anti-inflammatory features suggest that it acts by preventing the conversion of arachidonic acid to inflammatory prostaglandins.
Real World Application for injuries
Simply if your suffering from Joint pain, Ligament pain, cartilage pain, had surgery on bone, ligament or cartilage, Cissus is the supplement to use.
Some users will get instant relief and other will need to use Cissus for much longer period of time for complete healing of an injury.
THE OTHER SIDE EFFECT IS ANABOLIC!
Cissus is anabolic and anti-catabolic!!! Cissus users report a "PUMP" that we call the Cissus pump. The PUMP effect becomes prevalent at approximately 10-15 days of continous Cissus use. The "PUMP" is due to the increase of blood flow to the muscle. The Cissus pump will have you flexing your muscle for no apparent reason. This is when you know the product has exerted its effect.
This is a topic I will discus In depth in other Articles.
Now that we have covered how the (needtobuildmuscle pain relief stack) can be effective from the inside out. Le us now look into how it works from the outside in. Using our Super powerful Skeletal-balm
Skeletal-balm
A unique combination of natural nutrients formulated to relieve arthritis pain, muscle stiffness, soreness and to provide improved joint and muscle flexibility.
Using a powerful topical delivery system Skeletal-balm relieves pain and repairs joint and bone health.
The first and most powerful Ingredent in Skeletal-balm is Emu Oil
. Emu oil is a natural transdermal.
SpringerLink - Journal Article
Emu Oil Institute - Emu Oil Research
Research Proves Emu Oil Claims Valid
Our Skeletal-balm a Topically applied Joint and Muscle Reliever lotion is rich in Emu Oil, a transdermal anti-inflammatory and anti microbial. Comprised of concentrated Omega 3 fatty acids, Emu Oil naturally penetrates quickly and deeply carry effective nutrient, minerals and proteins to sore, inflammed muscles and joints.
Emu Oil Speeds cell regeneration and is naturally healing moisturizing and lubricating. It also acts as a transdermal carrier that has the ability to bring therapeutic ingredients deep into the skin. In addition, Emu Oil naturally contains a high level of Linoleic acid, a substance know to ease muscle and joint pain and Oleic acid, which provides a local anti-inflammatory effect.
Combining Emu oil and other other essential oils We have created a topical delivery system to deliver Methylsulfonylmethane (MSM) and other ingredents deep into the bone.
Topical Methylsulfonylmethane (MSM)
he potential benefits of MSM are extensive. MSM is an organic form of sulphur, the 3rd most vital nutrient in our body. In fact, sulphur is so essential to life that it is found everywhere, in every cell in every plant and animal on the planet. And, although it is available in foods we eat: meats, poultry, fish, eggs, dairy, most of it is lost in the processing, so supplementation with a reliable product could be potentially, extremely beneficial.
Most of us have heard of MSM's benefits in reducing or eliminating muscle soreness and cramps in aging patients and in athletes. It is well known that combined with the regenerative capabilities of glucosamine and chondroitin, MSM is proving to be a substantial player in the treatment of arthritis and other degenerative joint diseases. This powerful trio is now recognized as pivotal to any anti-arthritic regimen.
MSM's role as a molecular transporter is fascinating. It moves important nutrients to damaged cartilage and tissues, aiding in the control of the degeneration and pain of arthritis. The very small MSM molecules can pass easily through the skin and most tissues, enabling them to bind and escort sulfur atoms to their appropriate functional sites. Because of the many proteins, catalysts and enzymes which require a sulphur component in order to perform their specific jobs, a continual supply of sulphur must be provided to insure the 'normalizing' of these physiologic activities.
MSM (Methyl Sulfonyl Methane) was isolated by Robert Herschler and Dr. Stanley Jacob of the University of Oregon Medical School in the early 80's. Their research showed that MSM is a natural sulfur compound found in all living things. It revealed that MSM one of the most prominent compounds in our bodies, just behind water and sodium. In his research, Dr. Jacob found that the sulfur in MSM, called Sulfonyl, is as safe and is as important as vitamin C in our diet. He observed that it is very different than the bad sulfurs like sulfite, often used to preserve certain foods. MSM is a member of the sulfur family but should never be confused with sulfa drugs, to which some people are allergic. MSM is a natural form of organic sulfur found in all living organisms, including human body fluids and tissues. MSM originates in the ocean and reaches the human food chain through rainfall. MSM is an odorless, water-soluble, white crystalline material that supplies a bio-available form of dietary sulfur. While MSM is normally found in many common foods, including raw milk, meat, fish and a variety of fruits, vegetables, and grains, it is normally lost from our food by heating, storage, processing, drying, cooking and preserving and even washing. MSM has been shown to add flexibility to cell walls while allowing fluids to pass through the tissue more easily. MSM enhances tissue pliability and encourages the repair of damaged skin(6) MSM levels in humans decline with age, resulting in symptoms of fatigue, tissue and organ malfunction, and increased susceptibility to disease(6).
In a study of 24 people with athletic injuries, MSM was shown to reduce symptoms by nearly twice as much as those taking placebos, and was able to reduce the average needed visits to the chiropractor by approximately 60%(7). Another preliminary study compared 10 degenerative arthritis suffers taking MSM versus 6 who took a placebo. Results indicate a better than 80 percent control of pain within six weeks for those patients using MSM, while only two patients showed a minimal improvement (less than 20 percent) on the placebo(7). Dr. Lawrence, the medical doctor who headed up these studies, relates that he has treated more than one thousand patients with MSM and believes that it is safer than water. He noted that it appears that the body uses what it requires and flushes out the rest within 12 hours. According to a recent book by Lawrence, Jacob, and Zucker, entitled The Miracle of MSM, MSM can be a natural remedy for osteoarthritis, rheumatoid arthritis, Fibromyalgia, tendonitis and bursitis, muscular soreness and athletic injuries, carpal tunnel syndrome, post-traumatic inflammation and pain, heartburn and hyperacidity, headaches and back pain, and allergies. It was also noted that people taking MSM may notice other benefits, including softer skin, harder nails, thicker hair, and softening of scar tissue. An allotted time of 2 - 4 weeks may be needed before significant improvement is seen When using oral MSM but much faster when using topical.
Topical MSM is much faster and more powerful then Oral.
Skeletal-balm Uses Peppermint to help promote blood flow and reduce pain on contact. Acting as a natural Heating agent peppermint has been shown to reduce swelling,and relieve pain in most users.
Skeletal-balm Also has Aromatherapy Joint Pain Relief effects.
peppermint stimulates both hot and cold reactions in nerve endings in the skin. The brain registers these sensations at the same time. The contrast between the two messages makes a liniment seem much hotter than it really is.
muscle-relaxing and inflammation-reducing essential oils such as rosemary, marjoram, and lavender Then penetrate into the skin to work directly on the muscle giving a combined instant sensatory effect That relieves pain on contact.
Shea Butter
Several studies have shown shea butter to contain super effective anti-inflammatory compounds called triterpenes
The Shea Butter triterpenes are unique because they also stop inflammation throughout the body. In fact, research has shown that these are the most powerful inflammation fighter of any known botanical in the world. This is extremely important because pain is caused by inflammation so it is important to stop it is important to reduce inflammation as much as possible to remain pain free.
In addition to all its other amazing qualities, Shea Butter contains triterpene butyrospermol, a fat that penetrates deep into the skin. This is coupled with the presence of stigmasterol, a sterol known for its draining and anti-inflammatory properties
ALOE VERA - Provides healing, moisturizing, antiseptic, analgesic and anti-inflammatory properties. It’s natural penetrating action supplies moisture directly to tissues and stimulates the growth of healthy tissues. This is because Aloe Vera contains three natural analgesics for pain relief: magnesium, lupeol and salicylic acid. It also contains three natural anti-inflammatory agents for swelling, heat, redness and pain. This is why Aloe Vera is so effective for burns, cuts, scrapes and abrasions, as well as rheumatoid arthritis.These wonderful ingredients make “O” Shea J.A.M. a highly effective treatment for the temporary relief of: joint pain and stiffness, joint inflammation, back, hip, knee and arthritis pain, muscle pain, sore muscles, sprains, carpal tunnel syndrome.
Needtobuildmuscle.inc uses nothing but the most powerful pharmaceutical And cosmetic grade ingredients. Our customers satisfaction means everything to us. We pride our selfs on using the best,being the best and having the best.
Get the best joint aid,bone health,pain reliever stack on the market today at needtobuildmuscle.com For a affordable price.
FORGED Joint Care 
