another
http://groups.google.com/[email protected]&rnum=2
From: Elzi Volk (
[email protected])
Subject: Re: To Elzi: Fish oil AND Flax oil?
Newsgroups: misc.fitness.weights
Date: 2000-11-25 11:01:00 PST
"Lau Hansen" <
[email protected]> wrote:
>Elzi, you have recommended fish oil when dieting because the
>n-3 fatty acids in the fish oil have shown to prevent the body
>from going in starvation - correct?
No.
I advocate fish oil for several reasons, some of which are highly
individual. Omega-3 FAs are well documented to modulate cell
function and metabolism, with the following effects:
1) ratio of n-6, n-3 and cholesterol influences structural and
functional properties of cell membranes. n-3 increases fluidity and
possibly protein/receptor sensitivity in the membranes.
2) n-3s compete with n-6 to produce anti-inflammatory
eicosanoids.
3) production and release of several cytokines and other immune
system mediators are suppressed.
4) n-3s upregulate UCP1 in adipose tissue.
5) n-3 downregulates fatty acid synthase in white adipose tissue
The overall response to n-3 supplementation is:
1) improves various pathophysiological states, such as
cardiovascular disease, psoriasis, inflammatory conditions
2) improves post-injury and post-operative response, both stress
and immune status.
3) alters lipogenic activity in adipose tissue with a decrease in fat
mass in both animal and human subjects.
4) increases glucose clearance by upregulating GLUT4 transport
(although I suspect that may be more a function of incorporation
of GLUT4 transporters into the membrane).
5) possibly counteracting the muscle insulin resistance induced by
high muscle TG content (a source of muscle tissue insulin
resistance in obese people)
>As I have come to understand you say to stay on fish oil like 7
>days (low calories), then switch to flax for 2-3 days (high carb,
>above maintainance calories) - is that correct?
Depends on the individual's overall diet and fat mass. If food
sources of n-6 are relatively high and sources of n-3 are low,
there may be no need to switch. My only concern is the research
that showed downregulation of leptin in animal and huiman
subjects on high 0-3 supplementation. However, the data was
not adjusted for loss of fat mass, so this may just be a correlation
and less of causation. Nevertheless, leptin *is* a cytokine, so my
concern still remains. In folks carrying large amounts of fat mass,
this would not be an overwhelming concern as their plasma levels
are high anyway. Those who are relatively lean and where a
sustained energy deficit will result in decreased levels of leptin,
the effect of n-3 on leptin levels is more of a concern.
>But haven't flax oil also shown to prevent the starvation mode
>when dieting? why should one not take fish AND flax oil at the
>same time? how many grams of eicosapentaenoic acid and
>docosahexaenoic acid are necessary per day? My fish oil
>contains about. 1,5 grams of n-3 fatty acids per 15ml.
I'll have to pull out the relevant studies to see if I can extrapolate
effective dosages. I use pharmacological dosages of 10-16 g/day
to treat a chronic inflammation problem. I also derive a small
amount of n-6 from the fish oil and other sources, such as animal
products and vegetables, but it is limited.
If I don't address the issue above by Monday, remind me. Have
several projects going on right now.
Elzi