fhg43
New member
pa1ad said:It is my opinion that aromatase inhbitors (arimidex, 6-oxo) are much better for bodybuilders then estrogen receptor antagonists like clomid and tamoxifen. Both can raise testosterone levels but these ERT's have estrogenic activity in the liver which promotes undesirable effects like lowering of IGF-1 and raising of SHBG.
Okay....let's get back on topic
pa1ad-
I am a big fan of 1-AD. Had great luck with this past summer and hope to run an improved cycle this winter.
I ordered some 6-OXO and have decided to use that as my postcyle recovery supp. I was planning on using 300mg ED for 20 days. Does this sound like an appropriate dose? I was planning on running 1-AD @ 300-400mg for 6wks. This was a good dose for me last year. I was planning on adding some 4-AD (about 500mg ED) as well. I got good results.
Recently I read some studies that indicated aromatase inhibitors may actually lower IGF-1 levels (anastrozole-didn't see data on letrozole). As well I saw a study reporting that aromatase inhibitors (anastrozole) caused a rapid increase in atherosclerotic lesions in rat coronary arteries! Eeek!
Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase
Obviously you didn't do major clinical studies on 6-OXO, but would it have a similar side effect? Any thoughts on if the lesions would be specific to the pharmaceutical AIs or rats? 6-OXO is a suicide inhibitor so it works in a slightly different manner, correct? Besides causing aromatase to suicide does 6-OXO have any other hormonal effects like helping LH levels return to normal?
thanks,
FHG
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