GhettoStudMuffin said:
That study is a bit of a joke because depending on the delivery system of the supplement you need to get at least 1000mgs for a very efficient product to up to 3500mgs for a not so efficient product. You have to get enough of it for it to take effect because the main compound protodioscin is in such small quantities that it's necessary to get enough so that it works like it's supposed to.
Now tell me, how are you supposed to get any positive benefits from it when you're not even tkaing an effective dosage to see results. At 1.5mgs per pound of bodyweight, that's only 300mgs a day. That is nothing. No wonder no positive benefits were shown lmao.
Makes you wonder how smart these supposed scientists really are....
Yes, you are right about the active compound being usually found in small quantities. This is why recommendations are varied. Dosage is dependent on the active saponins. The active compounds of tribulus terrestris that may be responsible for its anabolic and aphrodisiac properties are the furostanol saponins, including protodioscin. Recently, two new saponins have been isolated from tribulus terrestris: Terrestrinins A and B.
I maintain my point about the high concentration of active saponins being very important: Different samples of tribulus have been analyzed, with significant differences in the composition of saponins observed depending on the origin and plant part used. One analysis of products showed considerable variations of 0.17 to 6.5 % in protodioscin content.
For all intent and purposes, this is why I have
according to Rehan Jalili, the head of the supplement research foundation trib works at a divided dose of about 750 to 1500 milligrams per day. "Great times to take it are first thing in the morning and one hour before a workout"
However, because of variations in active saponins, these reccomendations are sketchy at best, and probably apply only to a trib, which has the required high concentration of saponins.
For anyone thats interested, here are some abstracts purtaining to trib:
Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain.
J Ethnopharmacol. 2005 Jan 4;96(1-2):127-32.
Tribulus terrestris L. (Zygophyllaceae) have been used as an aphrodisiac both in the Indian and Chinese traditional systems of medicine. Administration of Tribulus terrestris extract increased sexual behaviour and intracavernous pressure both in normal and castrated rats and these effects were probably due to the androgen increasing property of tribulus. The objective of the present study is to evaluate the effect of tribulus on nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and androgen receptor (AR) immunoreactivity in rat brain. Twenty-four adult male Sprague-Dawley rats were divided into two groups of twelve each. Group I was treated with distilled water and Group II was treated with tribulus terrestris at the dose of 5mg/kg body weight orally, once daily for 8 weeks. Following treatment transcardiac perfusion was done with Ringer lactate, 4% paraformaldehyde and 30% sucrose. The brain tissue was removed and sections of the paraventricular (PVN) area of hypothalamus were taken for NADPH-d and AR immunostaining. There was an increase in both NADPH-d (67%) and AR immunoreactivity (58%) in tribulus terrestris treated group and these results were statistically significant compared to the control. Chronic treatment of tribulus terrestris in rats increases the NADPH-d positive neurons and AR immunoreactivity in the PVN region. Androgens are known to increase both AR and NADPH-d positive neurons either directly or by its conversion to oestrogen. The mechanism for the observed increase in AR and NADPH-d positive neurons in the present study is probably due to the androgen increasing property of tribulus terrestris. The findings from the present study add further support to the aphrodisiac claims of tribulus terrestris.
Investigation on inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris on hepatoma cell line BEL-7402
Zhongguo Zhong Yao Za Zhi. 2004 Jul;29(7):681-4.
To investigate the inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris on liver cancer cell line BEL-7402. CONCLUSION: saponins from tribulus terrestris exert its cytotoxic effect on BEL-7402 cells by inducing apoptosis.
A novel furostanol saponin from Tribulus terrestris of Bulgarian origin.
Fitoterapia. 2004 Mar;75(2):117-22.
The phytochemical investigation of the aerial parts of Tribulus terrestris of Bulgarian origin has resulted in the isolation of the novel furostanol saponin 1, named tribol, together with the known spirostanol saponins 2 and 3 and sitosterol glucoside.
Terrestrinins A and B, two new steroid saponins from Tribulus terrestris.
J Asian Nat Prod Res. 2003 Dec;5(4):285-90.
Two new steroid saponins, named terrestrinins A (1) and B (2), along with six known compounds were isolated from the Chinese medicine herb Tribulus terrestris.
Study of antihypertensive mechanism of Tribulus terestris in 2K1C hypertensive rats: role of tissue ACE activity.
Life Sci. 2003 Oct 24;73(23):2963-71.
Tribulus terrestris is a natural herb used for treating many diseases including hypertension. According to previous reports, aqueous extract of tribulus fruits may have some antihypertensive effect with an unknown mechanism. The present study investigated the antihypertensive mechanism of tribulus in 2K1C hypertensive rats by measurement of circulatory and local ACE activity in aorta, heart, kidney and lung. Four groups of rats were selected; control, sham, operated or hypertensive and tribulus treated hypertensive group. Hypertension was induced using silver clip on renal artery by surgery. Four weeks after surgery, a single daily dose of 10 mg/kg of lyophilized aqueous extract of tribulus fruit were given orally to rats for four weeks. The systolic blood pressure (SBP) was significantly increased in 2K1C rats compared to control rats. The SBP of tribulus fed hypertensive rats was significantly decreased compared to hypertensive rats. The ACE activity in all tissues of 2K1C rats including: aorta, heart, kidney, lung as well as serum were significantly increased compared to normal rats. The ACE activity in all tissues of tribulus fed hypertensive rats was significantly lower than that of hypertensive rats, which was more pronounced in kidney. These results indicated that there is a negative correlation between consumption of tribulus terrestris and ACE activity in serum and different tissues in 2K1C rats. tribulus terrestris tribulus tribulus side effects tribulus terrestis.
Effect of saponin from Tribulus terrestris on hyperlipidemia
Zhong Yao Cai. 2003 May;26(5):341-4.
The preventive and therapeutic effects of saponin from Tribulus terrestris on diet-induced hyperlipidemia in mice have been studied. It showed that in preventive experiment the tribulus terrestris saponin could significantly low the levels of serum total cholesterol and triglyceride.
The inhibitory effect of saponins from Tribulus terrestris on Bcap-37 breast cancer cell line in vitro
Zhong Yao Cai. 2003 Feb;26(2):104-6.
The inhibitory effect of saponins from Tribulus terrestris on Bcap37 breast cancer cell line were determined by cell growth curve, MTT assay, protein content assay and morphological observation. The results showed that saponins from tribulus terrestris had potent inhibitory effect on Bcap-37 cell line in a concentration-dependent manner. Bcap-37 cell exhibited morphological alteration, namely, cells got round and shrunk, nuclei contracted after treating with tribulus terrestris. tribulus terrestris side effects tribulus terrestris extract fuel tribulus.
Experimental Tribulus terrestris poisoning in sheep: clinical, laboratory and pathological findings.
Vet Res Commun. 2003 Jan;27(1):53-62.
Eleven native sheep, 1-2 years old, of both sexes were randomly divided into two groups, 6 sheep being allocated to the experimental group and 5 serving as controls. The sheep in the experimental group were fed 80% Tribulus terrestris and 20% alfalfa hay and wheat straw, while the control sheep were given a mixture of 40% alfalfa hay and 60% wheat straw. Clinical signs of hepatogenous photosensitivity were observed from day 11, including reddening and crust formation on the muzzle, nose, ears and eyelids, depression, weight loss, icterus, conjunctivitis, and yellow discoloration of the urine. Laboratory findings on weekly samples indicated significant differences in white blood cell count, total plasma protein and fibrinogen, total and direct bilirubin, blood urea nitrogen and creatinine concentrations. There were no significant differences in the packed cell volume, in the neutrophil, lymphocyte or eosinophil counts, or in the serum calcium, phosphorus, potassium, sodium or chloride concentrations. At necropsy of the animals consuming tribulus terrestris, there were various degrees of generalized icterus and the livers were swollen and discolored by bile pigment. Histopathological examination revealed varying amounts of crystalloid material in the bile ducts and renal tubules, hepatocellular degeneration, biliary fibrosis and proliferation, renal tubular necrosis and focal necrosis of cardiac muscle. bulgarian tribulus tribulus and terrestris and linn tribulus terestris canada terrestris tribulus extract tribulus extreme fuel tribulus product tribulus terristris tribulus.
Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats.
Life Sci. 2002 Aug 9;71(12):1385-96.
Tribulus terrestris has long been used in the traditional Chinese and Indian systems of medicine for the treatment of various ailments and is popularly claimed to improve sexual functions in man. Sexual behavior and intracavernous pressure (ICP) were studied in both normal and castrated rats to further understand the role of Tribulus terrestris containing protodioscin (PTN) as an aphrodisiac. Adult Sprague-Dawley rats were divided into five groups of 8 each that included distilled water treated (normal and castrated), testosterone treated (normal and castrated, 10 mg/kg body weight, subcutaneously, bi-weekly) and Tribulus terrestris treated (castrated, 5 mg/kg body weight, orally once daily). Decreases in body weight, prostate weight and ICP were observed among the castrated groups of rats compared to the intact group. There was an overall reduction in the sexual behavior parameters in the castrated groups of rats as reflected by decrease in mount and intromission frequencies (MF and IF) and increase in mount, intromission, ejaculation latencies (ML, IL, EL) as well as post-ejaculatory interval (PEI). Compared to the castrated control, treatment of castrated rats (with either testosterone or Tribulus terrestris extract) showed increase in prostate weight and ICP that were statistically significant. There was also a mild to moderate improvement of the sexual behavior parameters as evidenced by increase in MF and IF; decrease in ML, IL and PEI. It is concluded that Tribulus terrestris extract appears to possess aphrodisiac activity probably due to androgen increasing property of Tribulus terrestris (observed in our earlier study on primates).
Hypoglycemic effect of saponin from Tribulus terrestris
Zhong Yao Cai. 2002 Jun;25(6):420-2.
To study the hypoglycemic effect of saponins from Tribulus terrestris. The level of serum glucose could be significantly reduced by saponin from Tribulus terrestris, which was the rate of 26% and 40% in normal mice and diabetic mice in respectively. The level of serum triglyceride could be reduced 23%. The tribulus saponin could also decrease the content of serum cholesterol. Serum SOD activity of the mice was increased by the saponin. CONCLUSION: Saponin from Tribulus terrestris could significantly reduce the level of serum glucose. study tribulus review tribulus dhea tribulus tribulus woman wild bull tribulus information tribulus l terrestris tribulus fact terrestris tribulus extract german terrestris tribulus.
The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males.
Int J Sport Nutr Exerc Metab. 2000 Jun;10(2):208-15. tribulus terrestris extract
The purpose of this study was to determine the effects of the herbal preparation Tribulus terrestris (tribulus) on body composition and exercise performance in resistance-trained males. Fifteen subjects were randomly assigned to a placebo or tribulus (3.21 mg per kg body weight daily) group. Body weight, body composition, maximal strength, dietary intake, and mood states were determined before and after an 8-week exercise (periodized resistance training) and supplementation period. There were no changes in body weight, percentage fat, total body water, dietary intake, or mood states in either group. Muscle endurance (determined by the maximal number of repetitions at 100-200% of body weight) increased for the bench and leg press exercises in the placebo group (p <.05; bench press +/-28.4%, leg press +/-28.6%), while the tribulus terrestris group experienced an increase in leg press strength only . Supplementation with tribulus does not enhance body composition or exercise performance in resistance-trained males. tribulus research, tribulus terrestris.
Sexual behavior and intracavernous pressure (ICP) were studied in both normal and castrated rats to further understand the role of tribulus containing protodioscin (PTN) as an aphrodisiac. Adult Sprague-Dawley rats were divided into five groups of 8 each that included distilled water treated (normal and castrated), testosterone treated (normal and castrated, 10 mg/kg body weight, subcutaneously, bi-weekly) and tribulus treated (castrated, 5 mg/kg body weight, orally once daily). Decreases in body weight, prostate weight and ICP were observed among the castrated groups of rats compared to the intact group. There was an overall reduction in the sexual behaviour parameters in the castrated groups of rats as reflected by decrease in mount and intromission frequencies (MF and IF) and increase in mount, intromission, ejaculation latencies (ML, IL, EL) as well as post-ejaculatory interval (PEI). Compared to the castrated control, treatment of castrated rats (with either testosterone or tribulus extract) showed increase in prostate weight and ICP that were statistically significant. There was also a mild to moderate improvement of the sexual behaviour parameters as evidenced by increase in MF and IF; decrease in ML, IL and PEI. These results were statistically significant. It is concluded that tribulus extract appears to possess aphrodisiac activity.