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"Low HDL Levels"
- Thread starter Mr Beef
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40butpumpin
New member
hhajdo, my apologies because my post wasn't worded carefully enough bro. Unfortunately, I made it sound like you made such claims. I saw a post by a user on the following thread:
http://www.steroidology.com/forum/showthread.php?threadid=3585&highlight=niacin
and just made a statment based on that. My intention was definitely not to put you on the spot bro, or put words in your mouth.
For the record I've taken up to 5grams of No-Flush for extended periods of time with no problem whatsoever with my liver values. And yes, I've had them checked.
http://www.steroidology.com/forum/showthread.php?threadid=3585&highlight=niacin
and just made a statment based on that. My intention was definitely not to put you on the spot bro, or put words in your mouth.
For the record I've taken up to 5grams of No-Flush for extended periods of time with no problem whatsoever with my liver values. And yes, I've had them checked.
hhajdo
New member
LOL, it's OK bro...
Some flush free/time released preparations do seem to cause hepatic toxicity more frequently than unmodified preparations, but that doesn't seem to be the case with inositol hexanicotinate...
Am J Med 1992 Jan;92(1):77-81 Related Articles, Links
Hepatic toxicity of unmodified and time-release preparations of niacin.
Rader JI, Calvert RJ, Hathcock JN.
Division of Nutrition, Food and Drug Administration, Washington, DC 20204.
Niacin (nicotinic acid) is used frequently in the treatment of hypercholesteremia. It is available in both unmodified and time-release preparations. The latter were developed in attempts to minimize the skin-flushing reaction that affects virtually all users and may limit acceptance. Adverse effects on the liver from both unmodified and time-release preparations have been recognized for many years. We reviewed the literature on the hepatic toxicity of both types of niacin preparations. Adverse reactions in six patients resulted from the exclusive use of unmodified niacin and in two patients from the exclusive use of time-release preparations. In 10 additional patients, adverse reactions developed after an abrupt change from unmodified to time-release preparations. Many of these patients were ingesting time-release niacin at doses well above the usual therapeutic doses currently recommended. Signs of liver toxicity developed in less than 7 days in four of these 10 patients. In doses that achieve equivalent reductions in serum lipids, hepatic toxicity occurred more frequently with time-release preparations than with unmodified preparations. An awareness of toxicity associated with ingestion of high doses of time-release niacin preparations is important because of their widespread availability and the potential for self-prescribed, unmonitored use.
..."Vitamin B3 (as nicotinamide) may be toxic in the range 3-6gm/d85. Niacin, as nicotinic acid, is generally considered less toxic40, but, still, in some individuals large doses of niacin have caused abnormal liver behaviour. Also niacin can cause an uncomfortable, although, as far as we know, harmless and temporary skin flushing. Taken as inositol hexanicotinate, which is generally regarded as non-toxic, unlike some other slow-release formulations73, removes this problem..."
Some flush free/time released preparations do seem to cause hepatic toxicity more frequently than unmodified preparations, but that doesn't seem to be the case with inositol hexanicotinate...
Am J Med 1992 Jan;92(1):77-81 Related Articles, Links
Hepatic toxicity of unmodified and time-release preparations of niacin.
Rader JI, Calvert RJ, Hathcock JN.
Division of Nutrition, Food and Drug Administration, Washington, DC 20204.
Niacin (nicotinic acid) is used frequently in the treatment of hypercholesteremia. It is available in both unmodified and time-release preparations. The latter were developed in attempts to minimize the skin-flushing reaction that affects virtually all users and may limit acceptance. Adverse effects on the liver from both unmodified and time-release preparations have been recognized for many years. We reviewed the literature on the hepatic toxicity of both types of niacin preparations. Adverse reactions in six patients resulted from the exclusive use of unmodified niacin and in two patients from the exclusive use of time-release preparations. In 10 additional patients, adverse reactions developed after an abrupt change from unmodified to time-release preparations. Many of these patients were ingesting time-release niacin at doses well above the usual therapeutic doses currently recommended. Signs of liver toxicity developed in less than 7 days in four of these 10 patients. In doses that achieve equivalent reductions in serum lipids, hepatic toxicity occurred more frequently with time-release preparations than with unmodified preparations. An awareness of toxicity associated with ingestion of high doses of time-release niacin preparations is important because of their widespread availability and the potential for self-prescribed, unmonitored use.
..."Vitamin B3 (as nicotinamide) may be toxic in the range 3-6gm/d85. Niacin, as nicotinic acid, is generally considered less toxic40, but, still, in some individuals large doses of niacin have caused abnormal liver behaviour. Also niacin can cause an uncomfortable, although, as far as we know, harmless and temporary skin flushing. Taken as inositol hexanicotinate, which is generally regarded as non-toxic, unlike some other slow-release formulations73, removes this problem..."
40butpumpin
New member
DTOX said:
Na, that'll dehydrate you. You're better off with simple red grape juice. "It isn't the alcohol in the wine that provides a health benefit but the anti-oxidants, the red wine polyphenols, anthrocyanidins and resveratrol." (from: http://www.advance-health.com/redwine.html)
btw, resveratrol can be obtained from BAC among other places.
Well, niacin IS a B-Vitamin...and these are FAT soluble. So some preparations could be toxic if taken in large doses. They would have to be large though.
Same thing goes for all fat-soluble substances though...as they are the only ones that can enter cells. Even ALA is toxic b/c it is fat soluble(Around 30g for a 180lbs individual or thereabouts).
Fonz
Same thing goes for all fat-soluble substances though...as they are the only ones that can enter cells. Even ALA is toxic b/c it is fat soluble(Around 30g for a 180lbs individual or thereabouts).
Fonz
40butpumpin
New member
Fonz said:
Fonz B's are fat soluble? I thought A, D, E, K and a certain form of C (ascorbyl palmitate) were fat soluble, however, B's were not. Are you sure bro?
40butpumpin said:
No, they aren't(I'm an idiot today...lol).
Vitamin C is water soluble btw. Vit. E is fat soluble.
ALA is different. It is both fat and water soluble. i.e. Its a phospholipid.
Hence why there are 2 kinds of anti-oxidants: Fat and Water soluble. Vitamin E is fat Soluble while Vit. C is water soluble.
ALA is both.
Fonz
40butpumpin
New member
Not a problem bro......but there is both water and fat soluble C (ascorbyl palmitate). hehe Just a bad day bro.
...but there is both water and fat soluble C (ascorbyl palmitate). hehe Just a bad day bro.
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