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ANy time my man
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oral steroids,oral anabolic steroids,oral steroids cycles
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ANy time my man
needtogetaas
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We have all gotten medication from the pharmacy at one time or another. How many of us read the warning? Even more so how many of us read the little pamphlet that on drug interactions they give you with the medication. You know the little folded up peace of paper with thousands of tiny words.
Well Of course I am write lolol.. Every time i read one there is something that sticks out to me. Almost all of them always say " do not consume with grapefruit juice do to harmful interactions" or something along these lines. Some medications it interacts so much that they find it important to put this directly on the bottle.
So of course this got me thinking why? How does Grapefruit juice effect medication?
So I did some research and I found out as always.
A enzymes in the liver called CYP3A4 and CYP1A2 are responsible for the rake down of many things "including medications. They even does the job of braking down mythelation and or other oral steroids as well. A sabstance in grapefruit juice known as "Naringin" HAs been medically proven to brake down both the CYP3A4 and CYP1A2 enzymes in the liver.
CYP3A4
YP3A4 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens.[3]
Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to increase circulating drug levels.
The discovery that grapefruit juice can increase the oral availability of some medications was an accidental discovery made when grapefruit juice was used to mask the taste of ethanol in a study involving the calcium channel blocker felodipine. Since then, more different drugs have shown to enhance oral availability when consumed with grapefruit juice. Most of the drugs affected by grapefruit juice have highly variable oral bioavailability. In addition, most of these drugs are chiefly metabolized in the body by CYP3A4, an enzyme present in the liver and intestine.
The major effect of grapefruit juice appears to reduce “first-pass” metabolism by reducing CYP3A4 activity.
As little as 250 mL of grapefruit juice can change the metabolism of some drugs.3 This drug–food interaction occurs because of a common pathway involving a specific isoform of cytochrome P450 — CYP3A4 — present in both the liver and the intestinal wall. Studies suggest that grapefruit juice exerts its effect primarily at the level of the intestine but to some degree within the liver
After ingestion, a substrate contained in the grapefruit binds to the intestinal isoenzyme, impairing first-pass metabolism directly and causing a sustained decrease in CYP3A4 protein expression. Within 4 hours of ingestion, a reduction in the effective CYP3A4 concentration occurs, with effects lasting up to 24 hours. The net result is inhibition of drug metabolism in the intestine and increased oral bioavailability. Because of the prolonged response, separating the intake of the drug and the juice does not prevent interference.
Individuals express CYP3A4 in different proportions, those with the highest intestinal concentration being most susceptible to grapefruit juice/–naringin drug interactions. An effect is seen with the whole fruit as well as its juice,and naringin extracts so caution should be exercised with ALL. There is no similar reaction with orange juice, although there is some suspicion that "sour oranges" such as the Seville variety, may have some effect. A recent study, however, that tested the known interference of grapefruit juice with cyclosporine showed no similar effect with Seville oranges.
There is some interest in the potential therapeutic benefit of adding grapefruit juice to a drug regimen to increase oral bioavailability. The limitation is the individual variation in patient response. However, if the chemical that causes grapefruit's CYP3A4 inhibition is elucidated, there may be an opportunity to modulate that pathway in a controlled fashion.
What to do: Much of the data obtained on grapefruit juice–drug interactions involved measuring serum drug concentrations in small numbers of healthy volunteers. Because of the limited data and only occasional case reports, it is difficult to quantify the clinical significance for individual patients. One may assume that the interaction occurs primarily with oral medicines, and only with those that share the CYP3A4 metabolism pathway, with the consequence being increased oral bioavailability, higher serum drug concentrations and associated adverse effects.
One of the things I found most interesting is when you look for a list of drugs effected by grapefruit juice every known list has "dbol" on this list of drugs effected by grapefruit juice. This means that dbol is Highly effected by the CYP3A4 pathway! and i suspect that many other oral drugs also do go by route of CYP3A4 pathway.
Also a drug known as Cyprotraine a anti androgen/dht, is metabolized by the CYP3A4 enzyme, forming the active metabolite 15β-hydroxycyproterone acetate, which retains its antiandrogen activity, but has reduced progestational activity. Cyproterone acetate increases production of CYP3A4.
Dutasteride and SERMs are also metabolized by the CYP3A4 enzyme.
And lastly here is another list of drugs effected my the p450 enzyme system .
Statins (Cholesterol Lowering Drugs):
-Baycol (Cerivastatin)
-Mevacor (Lovastatin)
-Lipitor (Atorvastatin)
-Zocor (Simvastatin)
Antihistamines:
-Ebastine
-Seldane (Terfenadine, taken off the U.S. market)
Calcium Channel Blockers (Blood Pressure Drugs):
-Nimotop (Nimodipine)
-Nitrendipine
-Plendil (Felodipine)
-Pranidipine
-Sular (Nisoldipine)
Psychiatric Medications:
-Buspar (Buspirone)
-Halcion (Triazolam)
-Tegretol (Carbamazepine)
-Valium (Diazepam)
-Versed (Midazolam)
Intestinal Medications:
-Propulsid (Cisapride, taken off the U.S. market)
Immune Suppressants:
-Neoral (Cyclosporine)
-Prograf (Tacrolimus)
Pain Medications:
-Methadone
Impotence Drug:
-Viagra (Sildenafil)
Miscellaneous
-Losartan (Angiotensin II receptor blocker - ARB) - Grapefruit juice inhibits the body's ability to absorb the drug.
-Digoxin (for treating congestive heart failure) - Grapefruit juice inhibits the body's ability to absorb the drug.
Simple put many oral steroids are greatly enhanced by grapefruit juice or the extract naringin.
Well Of course I am write lolol.. Every time i read one there is something that sticks out to me. Almost all of them always say " do not consume with grapefruit juice do to harmful interactions" or something along these lines. Some medications it interacts so much that they find it important to put this directly on the bottle.
So of course this got me thinking why? How does Grapefruit juice effect medication?
So I did some research and I found out as always.
A enzymes in the liver called CYP3A4 and CYP1A2 are responsible for the rake down of many things "including medications. They even does the job of braking down mythelation and or other oral steroids as well. A sabstance in grapefruit juice known as "Naringin" HAs been medically proven to brake down both the CYP3A4 and CYP1A2 enzymes in the liver.
CYP3A4
YP3A4 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens.[3]
Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to increase circulating drug levels.
The discovery that grapefruit juice can increase the oral availability of some medications was an accidental discovery made when grapefruit juice was used to mask the taste of ethanol in a study involving the calcium channel blocker felodipine. Since then, more different drugs have shown to enhance oral availability when consumed with grapefruit juice. Most of the drugs affected by grapefruit juice have highly variable oral bioavailability. In addition, most of these drugs are chiefly metabolized in the body by CYP3A4, an enzyme present in the liver and intestine.
The major effect of grapefruit juice appears to reduce “first-pass” metabolism by reducing CYP3A4 activity.
As little as 250 mL of grapefruit juice can change the metabolism of some drugs.3 This drug–food interaction occurs because of a common pathway involving a specific isoform of cytochrome P450 — CYP3A4 — present in both the liver and the intestinal wall. Studies suggest that grapefruit juice exerts its effect primarily at the level of the intestine but to some degree within the liver
After ingestion, a substrate contained in the grapefruit binds to the intestinal isoenzyme, impairing first-pass metabolism directly and causing a sustained decrease in CYP3A4 protein expression. Within 4 hours of ingestion, a reduction in the effective CYP3A4 concentration occurs, with effects lasting up to 24 hours. The net result is inhibition of drug metabolism in the intestine and increased oral bioavailability. Because of the prolonged response, separating the intake of the drug and the juice does not prevent interference.
Individuals express CYP3A4 in different proportions, those with the highest intestinal concentration being most susceptible to grapefruit juice/–naringin drug interactions. An effect is seen with the whole fruit as well as its juice,and naringin extracts so caution should be exercised with ALL. There is no similar reaction with orange juice, although there is some suspicion that "sour oranges" such as the Seville variety, may have some effect. A recent study, however, that tested the known interference of grapefruit juice with cyclosporine showed no similar effect with Seville oranges.
There is some interest in the potential therapeutic benefit of adding grapefruit juice to a drug regimen to increase oral bioavailability. The limitation is the individual variation in patient response. However, if the chemical that causes grapefruit's CYP3A4 inhibition is elucidated, there may be an opportunity to modulate that pathway in a controlled fashion.
What to do: Much of the data obtained on grapefruit juice–drug interactions involved measuring serum drug concentrations in small numbers of healthy volunteers. Because of the limited data and only occasional case reports, it is difficult to quantify the clinical significance for individual patients. One may assume that the interaction occurs primarily with oral medicines, and only with those that share the CYP3A4 metabolism pathway, with the consequence being increased oral bioavailability, higher serum drug concentrations and associated adverse effects.
One of the things I found most interesting is when you look for a list of drugs effected by grapefruit juice every known list has "dbol" on this list of drugs effected by grapefruit juice. This means that dbol is Highly effected by the CYP3A4 pathway! and i suspect that many other oral drugs also do go by route of CYP3A4 pathway.
Also a drug known as Cyprotraine a anti androgen/dht, is metabolized by the CYP3A4 enzyme, forming the active metabolite 15β-hydroxycyproterone acetate, which retains its antiandrogen activity, but has reduced progestational activity. Cyproterone acetate increases production of CYP3A4.
Dutasteride and SERMs are also metabolized by the CYP3A4 enzyme.
And lastly here is another list of drugs effected my the p450 enzyme system .
Statins (Cholesterol Lowering Drugs):
-Baycol (Cerivastatin)
-Mevacor (Lovastatin)
-Lipitor (Atorvastatin)
-Zocor (Simvastatin)
Antihistamines:
-Ebastine
-Seldane (Terfenadine, taken off the U.S. market)
Calcium Channel Blockers (Blood Pressure Drugs):
-Nimotop (Nimodipine)
-Nitrendipine
-Plendil (Felodipine)
-Pranidipine
-Sular (Nisoldipine)
Psychiatric Medications:
-Buspar (Buspirone)
-Halcion (Triazolam)
-Tegretol (Carbamazepine)
-Valium (Diazepam)
-Versed (Midazolam)
Intestinal Medications:
-Propulsid (Cisapride, taken off the U.S. market)
Immune Suppressants:
-Neoral (Cyclosporine)
-Prograf (Tacrolimus)
Pain Medications:
-Methadone
Impotence Drug:
-Viagra (Sildenafil)
Miscellaneous
-Losartan (Angiotensin II receptor blocker - ARB) - Grapefruit juice inhibits the body's ability to absorb the drug.
-Digoxin (for treating congestive heart failure) - Grapefruit juice inhibits the body's ability to absorb the drug.
Simple put many oral steroids are greatly enhanced by grapefruit juice or the extract naringin.
needtogetaas
New member
Andriol: The oral that shuts the "must run test" peoples mouths
My friends as we all know ( from this thread and others) I have made my self one of the front runners and biggest advocates for the all oral cycle. Not because I think they are the best cycles or they are better then injecting. No I have done this to help put an end to all the Bro'ology out there on the forums. Keep in mind there is a huge difference between gymfriend'ology ( which is the worst of all) and Bro'ology. You see because of the internet we have now have excess to far more knowledge and experienced users then we ever did before. Now people don't have to get there steroid information from the local gym dip shit. Now instead of being a dumb ass like there friends and injecting what ever drug they get there hands on we can all learn the right way.
Sadly even among the great knowledge based steroid forums of the internet retardism has emerged in the form of "bro'ology" and we see it every day. Some one starts something some where and then it gets repeated over and over again by the masses of mindless bro's. On the very top of bro'ologies victims list sits "oral cycles". That is correct, bro'ologies biggest victim has been the oral cycle and I been working to change that.
Aside from the "clomid/nolva only for pct" fan club, no group of bro's has kept us in the stone age as much as the naysayers to oral cycles have. Many of us are trying to keep the knowledge on the forums advancing yet these pin heads keep knocking us all back again over and over all over the net. Now through out this thread We have refuted many of the common myths and comments repeated around the internet. But there has been a new retarded comment that has been emerging and that being " all cycles must have testosterone" and since test does not come in a safe oral form then again oral cycles suck.
Well sorry but oral haters you are wrong again!!!!!!! Not only can you run a cycle with out test but HA HA there is forms of oral testosterone TEE HEE.
Andriol (testosterone undecanoate)
O yes its out there my friends. Andriol is one bad ass steroid because besides methyltestosterone its the only other form of oral test out there but get this!!!! It is one of the safest oral steroids out there and has little to no effect on the liver. Its side effects are minimal to almost non at all and not only that it converts to estrogen at a far lesser rate then injectable forms of testosterone. IMo its only down side is price which we will cover later.
Andriol was Developed by the international drug firm Organon, And its one of the more newer bad boys on the block. Becaming available around the early 1980’s. Andriol contains 40 mg of testosterone undecanoate, based in oil (oleic acid) sealed inside a capsule. not counting the ester weight that leaves a dosage of approximately 25mg of sweat ass testosterone per cap!!
Normally Oral testosterone with out methylation would be rendered useless Because reabsorption through the portal vein leads directly to the liver where its then deactivated and can not pass without methylation. Testosterone undecanoate bypasses this action because its absorbed by the intestine through the "lymphatic system" thus making it effective. This is accomplished because of Testosterone undecanoates high fat solubility brought about by the ester, and its suspension in oil. Thus making it a safe, easy on the liver form of oral testosterone.
As stated before the only drawback to this compound is price. In order to get a descent amount of gains from Andriol one must consume at least (320-400mg) a day (8-10 caps). However this is only a problem if one were to use this compound on its own. Remember the subject at hand here is "oral cycle". And the fact that because you cant run test with them they are no good. For that matter IMO a light does of Andriol even as low as 240mg to 300mg can effectively be used in order to keep the side effects of low testosterone at bay!!! And that my friends is where Andriol comes in as the oral cycles uers secrete weapon against the oral cycles nay Sayers out there.
It is a good Idea that all cycles have a test best has always been a common saying around forums. Now oral cycles have there test base too. Now there is nothing a injected cycle has that a oral cycle can't. Yes it could be pricey and of course not every source carries it however its out there and its perfect for anyone who wants to add a little test to there oral cycle. PM me for any advice on this product my friends. As always thank you
My friends as we all know ( from this thread and others) I have made my self one of the front runners and biggest advocates for the all oral cycle. Not because I think they are the best cycles or they are better then injecting. No I have done this to help put an end to all the Bro'ology out there on the forums. Keep in mind there is a huge difference between gymfriend'ology ( which is the worst of all) and Bro'ology. You see because of the internet we have now have excess to far more knowledge and experienced users then we ever did before. Now people don't have to get there steroid information from the local gym dip shit. Now instead of being a dumb ass like there friends and injecting what ever drug they get there hands on we can all learn the right way.
Sadly even among the great knowledge based steroid forums of the internet retardism has emerged in the form of "bro'ology" and we see it every day. Some one starts something some where and then it gets repeated over and over again by the masses of mindless bro's. On the very top of bro'ologies victims list sits "oral cycles". That is correct, bro'ologies biggest victim has been the oral cycle and I been working to change that.
Aside from the "clomid/nolva only for pct" fan club, no group of bro's has kept us in the stone age as much as the naysayers to oral cycles have. Many of us are trying to keep the knowledge on the forums advancing yet these pin heads keep knocking us all back again over and over all over the net. Now through out this thread We have refuted many of the common myths and comments repeated around the internet. But there has been a new retarded comment that has been emerging and that being " all cycles must have testosterone" and since test does not come in a safe oral form then again oral cycles suck.
Well sorry but oral haters you are wrong again!!!!!!! Not only can you run a cycle with out test but HA HA there is forms of oral testosterone TEE HEE.
Andriol (testosterone undecanoate)
O yes its out there my friends. Andriol is one bad ass steroid because besides methyltestosterone its the only other form of oral test out there but get this!!!! It is one of the safest oral steroids out there and has little to no effect on the liver. Its side effects are minimal to almost non at all and not only that it converts to estrogen at a far lesser rate then injectable forms of testosterone. IMo its only down side is price which we will cover later.
Andriol was Developed by the international drug firm Organon, And its one of the more newer bad boys on the block. Becaming available around the early 1980’s. Andriol contains 40 mg of testosterone undecanoate, based in oil (oleic acid) sealed inside a capsule. not counting the ester weight that leaves a dosage of approximately 25mg of sweat ass testosterone per cap!!
Normally Oral testosterone with out methylation would be rendered useless Because reabsorption through the portal vein leads directly to the liver where its then deactivated and can not pass without methylation. Testosterone undecanoate bypasses this action because its absorbed by the intestine through the "lymphatic system" thus making it effective. This is accomplished because of Testosterone undecanoates high fat solubility brought about by the ester, and its suspension in oil. Thus making it a safe, easy on the liver form of oral testosterone.
As stated before the only drawback to this compound is price. In order to get a descent amount of gains from Andriol one must consume at least (320-400mg) a day (8-10 caps). However this is only a problem if one were to use this compound on its own. Remember the subject at hand here is "oral cycle". And the fact that because you cant run test with them they are no good. For that matter IMO a light does of Andriol even as low as 240mg to 300mg can effectively be used in order to keep the side effects of low testosterone at bay!!! And that my friends is where Andriol comes in as the oral cycles uers secrete weapon against the oral cycles nay Sayers out there.
It is a good Idea that all cycles have a test best has always been a common saying around forums. Now oral cycles have there test base too. Now there is nothing a injected cycle has that a oral cycle can't. Yes it could be pricey and of course not every source carries it however its out there and its perfect for anyone who wants to add a little test to there oral cycle. PM me for any advice on this product my friends. As always thank you
needtogetaas
New member
I am a pretty big fan of good orals. This however is a great example of a very bad oral steroid. Tren is toxic enough on its own with out mythelating it and making it oral. If you would like some oral cycles you can click the links in my first post they will take you to some. for more you can always pm me your ideas and i will go over them with you
Reinheart
New member
For my last cycle i did a combo of d-bol at 20mgs, restandol (240mgs) and proviron at 50mgs. I gained 27lbs and kept about 24.
I run the cycle for 6 weeks.
People who say that oral only cycles suck are ignorant assholes.
At this point i have to mention that i didn't feel shutdown at all while on cycle and believe it or not i gained both strength and size while on pct and i have actually lost bf.
I run the cycle for 6 weeks.
People who say that oral only cycles suck are ignorant assholes.
At this point i have to mention that i didn't feel shutdown at all while on cycle and believe it or not i gained both strength and size while on pct and i have actually lost bf.
needtogetaas
New member
Hell ya
CORRUPT COP
New member
Need to you are the fuckine man. I wish I was you. Thanks for this incerdible information.
Bump for Orals
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