-Animated.gif)
Please Scroll Down to See Forums Below
.jpg "Research Chemical Sciences")
.png "Research Chemical Sciences")
Nolvadex toxicity?
- Thread starter big_griff
- Start date
ILOVEMYWIFE
New member
I think anything oral can have some damage to your liver.
However, nothing I have ever read has mentioned anything about Nolvadex being
very liver toxic. I would be very hesitant to believe what your buddy is telling you.
Anyone else have a better answer.
However, nothing I have ever read has mentioned anything about Nolvadex being
very liver toxic. I would be very hesitant to believe what your buddy is telling you.
Anyone else have a better answer.
Cauliflower Ear
New member
bump....fuck hope its not...
macrophage69alpha
New member
: Annu Rev Pharmacol Toxicol. 2005;45:177-202. Links
The role of metabolic activation in drug-induced hepatotoxicity.Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP.
Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Buildings, Liverpool, Merseyside L69 3GE, United Kingdom. [email protected]
The importance of reactive metabolites in the pathogenesis of drug-induced toxicity has been a focus of research interest since pioneering investigations in the 1950s revealed the link between toxic metabolites and chemical carcinogenesis. There is now a great deal of evidence that shows that reactive metabolites are formed from drugs known to cause hepatotoxicity, but how these toxic species initiate and propagate tissue damage is still poorly understood. This review summarizes the evidence for reactive metabolite formation from hepatotoxic drugs, such as acetaminophen, tamoxifen, diclofenac, and troglitazone, and the current hypotheses of how this leads to liver injury. Several hepatic proteins can be modified by reactive metabolites, but this in general equates poorly with the extent of toxicity. Much more important may be the identification of the critical proteins modified by these toxic species and how this alters their function. It is also important to note that the toxicity of reactive metabolites may be mediated by noncovalent binding mechanisms, which may also have profound effects on normal liver physiology. Technological developments in the wake of the genomic revolution now provide unprecedented power to characterize and quantify covalent modification of individual target proteins and their functional consequences; such information should dramatically improve our understanding of drug-induced hepatotoxic reactions.
The role of metabolic activation in drug-induced hepatotoxicity.Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP.
Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Buildings, Liverpool, Merseyside L69 3GE, United Kingdom. [email protected]
The importance of reactive metabolites in the pathogenesis of drug-induced toxicity has been a focus of research interest since pioneering investigations in the 1950s revealed the link between toxic metabolites and chemical carcinogenesis. There is now a great deal of evidence that shows that reactive metabolites are formed from drugs known to cause hepatotoxicity, but how these toxic species initiate and propagate tissue damage is still poorly understood. This review summarizes the evidence for reactive metabolite formation from hepatotoxic drugs, such as acetaminophen, tamoxifen, diclofenac, and troglitazone, and the current hypotheses of how this leads to liver injury. Several hepatic proteins can be modified by reactive metabolites, but this in general equates poorly with the extent of toxicity. Much more important may be the identification of the critical proteins modified by these toxic species and how this alters their function. It is also important to note that the toxicity of reactive metabolites may be mediated by noncovalent binding mechanisms, which may also have profound effects on normal liver physiology. Technological developments in the wake of the genomic revolution now provide unprecedented power to characterize and quantify covalent modification of individual target proteins and their functional consequences; such information should dramatically improve our understanding of drug-induced hepatotoxic reactions.
macrophage69alpha
New member
Carcinogenesis. 1995 Jul;16(7):1661-4. Links
DNA adducts caused by tamoxifen and toremifene in human microsomal system and lymphocytes in vitro.Hemminki K, Widlak P, Hou SM.
Center for Nutrition and Toxicology, Karolinska Institute, Huddinge, Sweden.
DNA-binding of tamoxifen and toremifene was studied in rat in vivo, in human and rat microsomes in vitro, and in cultured primary human lymphocytes by 32P-postlabelling. Only tamoxifen caused DNA adducts in rat liver. Both compounds induced adducts in both rat and human microsomal systems and in cultured lymphocytes. The levels of adducts in microsomes and lymphocytes were low, ca. 1 adduct/10(9) nucleotides. Toremifene showed lower binding in each system, and in lymhocytes adducts were only detected at a cytotoxic dose level.
PMID: 7614704
DNA adducts caused by tamoxifen and toremifene in human microsomal system and lymphocytes in vitro.Hemminki K, Widlak P, Hou SM.
Center for Nutrition and Toxicology, Karolinska Institute, Huddinge, Sweden.
DNA-binding of tamoxifen and toremifene was studied in rat in vivo, in human and rat microsomes in vitro, and in cultured primary human lymphocytes by 32P-postlabelling. Only tamoxifen caused DNA adducts in rat liver. Both compounds induced adducts in both rat and human microsomal systems and in cultured lymphocytes. The levels of adducts in microsomes and lymphocytes were low, ca. 1 adduct/10(9) nucleotides. Toremifene showed lower binding in each system, and in lymhocytes adducts were only detected at a cytotoxic dose level.
PMID: 7614704
S
Stray800
Guest
Liquid Nolva sure as hell tastes toxic... 
Big_Joe
New member
macrophage69alpha said:
I also did a pubmed search on this topic. What bothers me is they don't give dosages that toxicity becomes apparent. None of the studies that I read on Pubmed gave dosages that showed toxic effect. Nor did they give the dosage that was used in the study. But I know that there are a whole lot of people that are on tamoxifen. If liver toxicity was a magor problem they would be dropping like flies because they already have major health problems.
Similar threads
