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Long-Term Glucosamine Sulfate Use Appears to Modify Osteoarthritis


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Excerpt: Long-Term Glucosamine Sulfate Use Appears to Modify Osteoarthritis WESTPORT, CT (Reuters Health) Jan 25 - Among patients with knee osteoarthritis, long-term use of glucosamine sulfate appears to prevent changes in joint structure and significantly improve symptoms, according to a report in the January 27th issue of The Lancet. Dr. Jean Yves Reginster from the University of Liege, Belgium, and

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  1. #1
    Elite Mentor Mr H's Avatar
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    Long-Term Glucosamine Sulfate Use Appears to Modify Osteoarthritis


    WESTPORT, CT (Reuters Health) Jan 25 - Among patients with knee
    osteoarthritis, long-term use of glucosamine sulfate appears to prevent
    changes in joint structure and significantly improve symptoms, according
    to a report in the January 27th issue of The Lancet.


    Dr. Jean Yves Reginster from the University of Liege, Belgium, and
    colleagues randomized 212 patients with knee osteoarthritis to 1500 mg of
    glucosamine sulfate, or placebo, once a day for 3 years. At baseline and
    at 1 and 3 years, the researchers obtained anteroposterior radiographs of
    each knee and assessed mean joint space and mean joint-space width.


    Among the 106 patients who received glucosamine sulfate there was no
    significant joint-space loss after 3 years (mean loss -0.31 mm), Dr.
    Reginster's group reports. However, among the 106 patients in the placebo
    group, the investigators found progressive joint-space narrowing, with
    nonsignificant mean joint-space loss of -0.06 mm. The differences in
    minimum joint-space narrowing were similar, they note.


    When Dr. Reginster's team assessed osteoarthritis symptoms, using the
    Western Ontario and McMaster Universities (WOMAC) osteoarthritis index,
    they found that among the patients receiving glucosamine sulfate, scores
    improved by 20% to 25%, while among patients in the placebo group, scores
    worsened slightly.

    Noting that glucosamine is widely available as a nutritional supplement in
    the US and the UK, Dr. Tim McAlindon from Boston University Medical Center
    says in a journal editorial that because patients do not rely on
    physicians for nutritional advice, glucosamine is likely to be
    self-prescribed, leaving the physician out of the treatment loop.

    "This situation must change," he says. "It is time for the profession to
    accommodate the possibility that many nutritional products may have
    valuable therapeutic effects and to regain the credibility of the public
    at large."

  2. #2
    Pro Bodybuilder Badkins21's Avatar
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    I have to agree with that...I've only been on it for about 3 weeks now, combined with MSM, both at doses = to twice the recommended, and I haven't had any joint pain this week...with all the weight gain from my first cycle this winter, I was starting to feel like an old man, hehe...

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