Oxidative stress is caused on the liver at the cellular membrane on hepatocytes(liver cells). This is done when the steroid is actually destroyed. So, simply bc injectable winny bypasses first metabolism (buzz word for not being deactivated by a oxidative enzyme in bile) as most steroids (E2, testosterone, fina, etc) would be .. or the large majority would be) doesnt mean it is any less harsh for oxidative damage than oral administration. if anything i would assume it would be more harsh. since sublingual or oral administration is less efficient than IM delivery.