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Unfortunately anabolic steroids at dosages used in bodybuilding can have very negative effects on blood lipids. Total cholesterol, LDL cholesterol (bad), and triglycerides (TG) levels can go up and HDL cholesterol (good) can be drastically reduced. This can all result in a very atherogenic environment, setting one up for a heart attack. This effect of steroids may last for months while OFF cycle.
Now the good news. Pantethine which is the active form of pantothenic acid (vitamin B5) has been shown to decrease total and LDL cholestol, decrease TG, and increase HDL. Note, this effect is NOT seen with pantothenic acid, rather only with pantehine. Pantethine is a precursor to Acetyl COA. It has been shown both in in-vitro and in-vivo studies in both animals and humans that pantethine can inhibit cholesterol and fatty acid synthesis (it can also reduce viscelra fat).
The effective dose is 300mg three times a day. It can be bought in some health food stores, but look into internet wholesalers for cheaper prices (but make sure it's pharmaceutical grade Pantethine). Hope this helps some Bros.
This is one of several abstracts that can be found in the literaure:
Acta Biomed Ateneo Parmense 1987;58(5-6):143-
Clinical use of pantethine by parenteral route in the treatment of hyperlipidemia
Arsenio L, Bodria P, Bossi S, Lateana M, Strata A.
Servizio di Malattie del Ricambio e Diabetologia, Ospedali Riuniti, Parma.
Recent investigations have confirmed the effectiveness and the excellent tolerability of pantethine, a derivative of pantetheine, an essential part of the acetylation coenzyme CoA, administered P.O., in normalizing the blood lipid concentrations of patients with hyperlipidemias. A group of 18 patients with hyperlipidemias (9 M, 9 F), with an average age of 52.6 years, was submitted to pantethine parenteral treatment. After a 20 days wash-out, pantethine (400 mg/day; BID) was administered intramuscularly, for 20 days. Total cholesterol, triglycerides, HDL-cholesterol, apo A-1 and B lipoprotein, uric acid in serum, glycemia, CBC, B.U.N., creatininemia, E.S.R., SGOT, SGPT, bilirubinemia, cardiac frequency, blood pressure and body weight were controlled before and after treatment. The drug showed to have a therapeutic effectiveness by a rapid and significant improvement in the blood lipid pattern with reduction of total cholesterol, triglycerides and apo-B lipoprotein and increase of HDL-cholesterol and apo A-1 lipoprotein. The tolerability of pantethine at the stated dosage and mode of administration was invariably excellent, with non complaints or visible side effects imputable to the test drug. BUN, creatininemia, glycemia, SGOT, SGPT, bilirubinemia, E.S.R., CBC, cardiac frequency and blood pressure readings showed no noteworthy changes throughout the study.
Now the good news. Pantethine which is the active form of pantothenic acid (vitamin B5) has been shown to decrease total and LDL cholestol, decrease TG, and increase HDL. Note, this effect is NOT seen with pantothenic acid, rather only with pantehine. Pantethine is a precursor to Acetyl COA. It has been shown both in in-vitro and in-vivo studies in both animals and humans that pantethine can inhibit cholesterol and fatty acid synthesis (it can also reduce viscelra fat).
The effective dose is 300mg three times a day. It can be bought in some health food stores, but look into internet wholesalers for cheaper prices (but make sure it's pharmaceutical grade Pantethine). Hope this helps some Bros.
This is one of several abstracts that can be found in the literaure:
Acta Biomed Ateneo Parmense 1987;58(5-6):143-
Clinical use of pantethine by parenteral route in the treatment of hyperlipidemia
Arsenio L, Bodria P, Bossi S, Lateana M, Strata A.
Servizio di Malattie del Ricambio e Diabetologia, Ospedali Riuniti, Parma.
Recent investigations have confirmed the effectiveness and the excellent tolerability of pantethine, a derivative of pantetheine, an essential part of the acetylation coenzyme CoA, administered P.O., in normalizing the blood lipid concentrations of patients with hyperlipidemias. A group of 18 patients with hyperlipidemias (9 M, 9 F), with an average age of 52.6 years, was submitted to pantethine parenteral treatment. After a 20 days wash-out, pantethine (400 mg/day; BID) was administered intramuscularly, for 20 days. Total cholesterol, triglycerides, HDL-cholesterol, apo A-1 and B lipoprotein, uric acid in serum, glycemia, CBC, B.U.N., creatininemia, E.S.R., SGOT, SGPT, bilirubinemia, cardiac frequency, blood pressure and body weight were controlled before and after treatment. The drug showed to have a therapeutic effectiveness by a rapid and significant improvement in the blood lipid pattern with reduction of total cholesterol, triglycerides and apo-B lipoprotein and increase of HDL-cholesterol and apo A-1 lipoprotein. The tolerability of pantethine at the stated dosage and mode of administration was invariably excellent, with non complaints or visible side effects imputable to the test drug. BUN, creatininemia, glycemia, SGOT, SGPT, bilirubinemia, E.S.R., CBC, cardiac frequency and blood pressure readings showed no noteworthy changes throughout the study.
