You definitely can take it year round, and as a matter of fact, this is exactly what I do. So far, in over 2 years I have not had even minor issues. Remember, it is DHT the one causing hairloss, and HCGenerate ES does not cause an increase in DHT levels, so you will be absolutely safe from this, and other side effects because it will raise your natural testosterone levels to their natural maximums, where no side effects take place.