I've been taking a weekly (self admistered) shot for 2 years straight now and I plan to be on for life. I feel great and at 39, I continue to grow and make gains in the gym. I keep my blood levels monitored twice a year. So I think I'm on the right track. The thing is, some guys are calling my crazy because I never come off. I don't understand why they think this, especially since some of you guys get it weekly by your dr's. The dosages are relatively low and it doesn't place much stess on the liver. Other meds that people take for life, I'm sure are far more toxic.