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Research Chemical SciencesUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsResearch Chemical SciencesUGFREAKeudomestic

GH secretagogues

sigmund

New member
Does anyone know what happened to Merck-677?

I found the following info but have no idea if it’s still in development:

MK-677: A secretagogue that causes the body to increase its natural GH release by mimicking GHRH. MK-677 works to enhance the body’s natural/pulsatile Growth Hormone secretion patterns, as opposed to causing sudden increases in circulating GH.

Early studies showed it to reverse diet-induced muscle loss in healthy adults. A single oral 25 mg dose per day was all that was needed to reverse muscle wasting during caloric restriction (18Kcal/kg/day).

Synthetic GH (191 amino acid long protein) is only one of the many forms of GH found naturally in the body. It is the most prevalent form (makes up about 40% of total GH) but there are other forms.

GH secretagogues such as Merck's MK677 should prove more valuable than synthetic GH as they will induce secretion of all the various forms of GH.

In studies comparing exogenous GH administration Vs administration of MK677 in doses that induce release of comparable quantities of GH, the MK677 group had significantly better results (body composition among other measured variables).

Merck were trying to find as many applications for this drug as possible but I’m unable to find any current information on it or similar GH secretagogues.
 
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