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Research Chemical SciencesUGFREAKeudomestic
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Fertility

Jenetic

Don Anabolico
Platinum
Semen analysis is the major test for evaluating male infertility. This test provides important information about the quality and quantity of the sperm. The semen sample is analyzed for volume, viscosity (thickness), pH and color of the ejaculate, sperm concentration, motility, morphology, and forward progression of the sperm. The sample is also examined for the presence of white or red blood cells which may indicate infection or inflammation.

In patients who desire fertility, the options to induce spermatogenesis include exogenous gonadotropins or pulsatile GnRH. In hypogonadotropic hypogonadism, the origin of the disease influences the choice of treatment to achieve fertility. GnRH substitution is more effective for hypothalamic than pituitary disorders. However, depending on the number of functioning gonadotropes remaining, GnRH may also be an effective therapy for patients with hypopituitarism.

Administration of exogenous gonadotropins is suitable for patients with both pituitary and hypothalamic disorders. Conventional therapy uses hCG as an LH substitute in conjunction with FSH in the form of either human menopausal gonadotropins (HMG) or recombinant FSH formulations (rFSH).

The alternative to gonadotropin therapy is pulsatile administration of GnRH, which may be administered by a programmable, portable mini-infusion pump. While intravenous administration produces the most physiologic GnRH pulse contour and ensuing LH response, the subcutaneous route is clearly more practical for the longterm treatment required to stimulate spermatogenesis. The frequency of GnRH administration is normally employed is every 2 hours. The dose of GnRH is titrated for each individual to ensure normalization of testosterone, LH and FSH and varies from 25 to 600 ng/kg per bolus. Patients on longterm therapy are monitored with serum testosterone and gonadotropin levels at monthly intervals. Once testicular volume reaches 8 mL, regular semen analyses are obtained. The majority of patients require treatment for at least 2 years to maximize testicular growth and achieve spermatogenesis, although the time taken to reach these endpoints tends to be shorter in those with a larger initial gonadal size.

Both exogenous gonadotropins and pulsatile GnRH are very effective in stimulating spermatogenesis. Most studies have no shown no advantage of either therapy in terms of testicular growth, onset of spermatogenesis, final sperm counts or pregnancy rates. However, there are some data to suggest that testicular growth is greater and the time taken to achieve spermatogenesis is shorter in patients treated with GnRH

Jenetic
 
But is a "programmable, portable mini-infusion pump" really practical?
 
Ulcasterdropout said:
But is a "programmable, portable mini-infusion pump" really practical?

Extreme times call for extreme measures to be taken. In most cases, the combination of HCG and an FSH preparation (HMG/rFSH) is sufficient. GnRH is normally the second option, due to the reason you mentioned, if the HCG and FSH treatment fail.

Jenetic
 
I am unfamiliar with the latter gonadotropic treatments.
I know of HCG usage to mimic LH for steroid induced hypogonadism (pretty much the gold standard now), but I've never seen the others - FSH as HMG, rFSH, or GnRH (Gonadorelin prolly).
I couldn't see me calibrating a Lutrepulse :worried: ;)
 
FSH in the form of HMG or rFSH is used for the induction of spermatogenesis.

Jenetic
 
Ulcasterdropout said:
I am unfamiliar with the latter gonadotropic treatments.
I know of HCG usage to mimic LH for steroid induced hypogonadism (pretty much the gold standard now), but I've never seen the others - FSH as HMG, rFSH, or GnRH (Gonadorelin prolly).
I couldn't see me calibrating a Lutrepulse :worried: ;)


Get yourself a copy of the world anabolic review 1996.. is all in there, laymans terms! :coffee:
 
Ulcasterdropout said:
I couldn't see me calibrating a Lutrepulse :worried: ;)

I highly doubt you would be able to obtain it without the recommendation and prescription of an experienced physician. Therefore, you wouldn't need to worry about calibrating the unit yourself as your physician would designate your dosage and more than likely explain to you all the operational details and precautions to operating a device such this.

Jenetic
 
Jenetic said:
The majority of patients require treatment for at least 2 years to maximize testicular growth and achieve spermatogenesis, although the time taken to reach these endpoints tends to be shorter in those with a larger initial gonadal size.
Jenetic
Bro, are you serious? 2 Years to conceive a child? What if your wife is 35? They say risks go up after 35. Are you talking about the typical recreational AAS user or someone with problems stemming from more than HPTA suppression due to exogenous testosterone and its derivatives (anabolics)? Are you talking about someone with more serious medical problems? I'd hate to think I would need 2 years of medical intervention to undo any steroid-induced effects on HPTA and fertility.
 
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