Please Scroll Down to See Forums Below 
.jpg "Research Chemical Sciences")
.png "Research Chemical Sciences")
The_Chemist
New member
A Dr recently linked me to this study showing significantly reduced sperm counts in men taking dutasteride. This effect was not found in men taking finasteride. After reading this, im going to get a sperm test to make sure, and ill post the results next week.
If you access http://www.rxlist.com/cgi/generic4/avodart_ad.htm, you will read that “The effects of dutasteride 0.5 mg/day on semen characteristics were evaluated in normal volunteers aged 18 to 52 (n = 27 dutasteride, n = 23 placebo) throughout 52 weeks of treatment and 24 weeks of post-treatment follow-up. At 52 weeks, the mean percent reduction from baseline in total sperm count, semen volume, and sperm motility were 23%, 26%, and 18%, respectively, in the dutasteride group when adjusted for changes from baseline in the placebo group.
I will repeat what I already told you, “Most of the panel members at the International Society of Hair Restoration Surgery October 18-22, 2006, which I attended in San Diego, did not approve of the use of dutasteride for treating MPB. They sited an additional finding that the sperm count in patients taking dutasteride were low (as low as 10%)and that the sperm count remained low even 6 months after discontinuing dutasteride.”
They both reduce serum level DHT, but the systemic reduction of DHT is not the same everywhere in the body for either drug, i.e. Propecia will lower the serum level of DHT by 60-80% and in the scalp DHT by only ~37%. The DHT reduction at the follicle is far less than the 60%-80% because the predominant enzyme that converts testosterone to DHT in the scalp is type 1, 5-alpha reductase, which is not affected by finasteride.
Dutasteride on the other hand is a dual 5 alpha-reductase inhibitor. A daily dose of 0.5 mg dutasteride will reduce the serum level of DHT by 90%-95%, but the DHT level in the scalp is reduced by only 54%.
If you access http://www.rxlist.com/cgi/generic4/avodart_ad.htm, you will read that “The effects of dutasteride 0.5 mg/day on semen characteristics were evaluated in normal volunteers aged 18 to 52 (n = 27 dutasteride, n = 23 placebo) throughout 52 weeks of treatment and 24 weeks of post-treatment follow-up. At 52 weeks, the mean percent reduction from baseline in total sperm count, semen volume, and sperm motility were 23%, 26%, and 18%, respectively, in the dutasteride group when adjusted for changes from baseline in the placebo group.
I will repeat what I already told you, “Most of the panel members at the International Society of Hair Restoration Surgery October 18-22, 2006, which I attended in San Diego, did not approve of the use of dutasteride for treating MPB. They sited an additional finding that the sperm count in patients taking dutasteride were low (as low as 10%)and that the sperm count remained low even 6 months after discontinuing dutasteride.”
They both reduce serum level DHT, but the systemic reduction of DHT is not the same everywhere in the body for either drug, i.e. Propecia will lower the serum level of DHT by 60-80% and in the scalp DHT by only ~37%. The DHT reduction at the follicle is far less than the 60%-80% because the predominant enzyme that converts testosterone to DHT in the scalp is type 1, 5-alpha reductase, which is not affected by finasteride.
Dutasteride on the other hand is a dual 5 alpha-reductase inhibitor. A daily dose of 0.5 mg dutasteride will reduce the serum level of DHT by 90%-95%, but the DHT level in the scalp is reduced by only 54%.
