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Research Chemical SciencesUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsResearch Chemical SciencesUGFREAKeudomestic

Dutasteride?

I think will be much better than Finasteride...As far as I know Dutasteride its only avaliable in Sweden.

Dutasteride - better than propercia

The best new medicine is called DUTASTERIDE made by Glaxo Wellcome...Is suppose to be avaliable this year...Read the article:

EFFECTIVE SUPPRESSION OF DIHYDROTESTOSTERONE (DHT) BY DUTASTERIDE, A NOVEL, DUAL 5 ALPHA REDUCTASE INHIBITOR.

Richard V Clark, David J Hermann, Hoda Gabriel, Timothy H Wilson, Betsy B Morrill, and Stuart Hobbs.
Research Triangle Park, NC (presented by Dr. Clark)

INTRODUCTION AND OBJECTIVES

DHT is formed from testosterone (T) by Type 1 and Type 2 5 a reductase enzyme (5AR). DHT plays a key role
in the development and progression of benign prostatic hyperplasia (BPH). Dutasteride is the first dual inhibitor of both 5AR isozymes. We compared hormonal effects of dutasteride with placebo and finasteride, a Type 2 5AR inhibitor.

METHODS

One group of 53 subjects was studied for 4 weeks and received dutasteride at 0.1, 0.5, 2.5, 5.0mg and 2.5mg
with a 40mg loading dose, placebo, or 5mg finasteride daily. A second group of 313 subjects was studied for 24 weeks and received dutasteride at 0.01, 0.05, 0.5, 2.5, or 5.0mg, placebo, or 5mg finasteride daily. Studies
were randomized, double blinded, with a parallel group design. All subjects had BPH, prostate volume >= 30ml
or IPSS >= 8. Dutasteride groups were compared to placebo and finasteride by a general linear model with
pairwise comparisons, and a sigmoid Emax model for DHT dose response.

RESULTS

Dutasteride suppressed DHT in dose related fashion with maximal suppression >= 95% at the 5.0mg dose. The lowest maximally effective dose was 0.5mg, with 90% DHT suppression at 4 wks, increasing to 94% at 24 wks, while finasteride suppressed DHT by 67% and 76% respectively. T rose in conjunction with DHT suppression, ranging from 9 to 27%, but mean T levels with both dutasteride and finasteride remained within the normal range.
Laboratory studies and ECG's remained normal during the studies. Adverse events were typical, non-specific
events and were reported at comparable rates to placebo for both compounds, except for decreased libido with 5.0mg dutasteride and finasteride.

CONCLUSIONS

Dutasteride, a dual inhibitor of 5AR, achieved significantly greater suppression of DHT with less subject
variability compared to finasteride. The increase in T at maximally effective doses of dutasteride was not
considered clinically significant as mean T levels remained in the normal range. Dutasteride was well tolerated at all dose levels studied with a safety profile comparable to placebo except for a mild decrease in libido also noted with finasteride. The consistent and increased suppression of DHT by dutasteride may show greater clinical benefit in the treatment of BPH. This is currently being investigated with the 0.5mg dose in large-scale phase III clinical trials.

SOURCE OF FUNDING

GlaxoWellcome Research and Development.
 
Dutasteride looks more promising than Proscar. It is now available in US pharmacies, but because it is so new, not everyone carries it. You would need to call your local pharmacy for availability.
 
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