Yes they REALY DO WORK......i personally took the recomended dose x3 as it is safe to do so...just spread the doses out...i had a realy bad shoulder....Zygo the Zygot recomended i take..MSm, Glucosamine, and DSM....i was completely sur ei would need surgery....i gave it 3 months with light rehab and i was back up and lifting. Give it time!