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genezapharmateuticals
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Research Chemical SciencesUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsResearch Chemical SciencesUGFREAKeudomestic

curcumin and muscle regeneration

I'm not sure. Here is the abstract and a link to the full study.

http://www.ncbi.nlm.nih.gov:80/entr...?page=C320&pmidlookup?view=full&pmid=10444409[/url]


Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury.

Thaloor D, Miller KJ, Gephart J, Mitchell PO, Pavlath GK.

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Skeletal muscle is often the site of tissue injury due to trauma, disease, developmental defects or surgery. Yet, to date, no effective treatment is available to stimulate the repair of skeletal muscle. We show that the kinetics and extent of muscle regeneration in vivo after trauma are greatly enhanced following systemic administration of curcumin, a pharmacological inhibitor of the transcription factor NF-kappaB. Biochemical and histological analyses indicate an effect of curcumin after only 4 days of daily intraperitoneal injection compared with controls that require >2 wk to restore normal tissue architecture. Curcumin can act directly on cultured muscle precursor cells to stimulate both cell proliferation and differentiation under appropriate conditions. Other pharmacological and genetic inhibitors of NF-kappaB also stimulate muscle differentiation in vitro. Inhibition of NF-kappaB-mediated transcription was confirmed using reporter gene assays. We conclude that NF-kappaB exerts a role in regulating myogenesis and that modulation of NF-kappaB activity within muscle tissue is beneficial for muscle repair. The striking effects of curcumin on myogenesis suggest therapeutic applications for treating muscle injuries.

PMID: 10444409 [PubMed - indexed for MEDLINE]
 
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Curcumin is tumeric extract, btw. It is sold by supplement companies. But absorption is poor so they are combining it with piperine (black pepper extract) to boost absorption by 2000% (20 times.)
 
Cytokines and oxidative signalling in skeletal muscle.

Reid MB, Li YP.

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

A growing body of literature indicates that cytokines regulate skeletal muscle function, including gene expression and adaptive responses. Tumour necrosis factor-alpha (TNF-alpha) is the cytokine most prominently linked to muscle pathophysiology and, therefore, has been studied most extensively in muscle-based systems. TNF-alpha is associated with muscle catabolism and loss of muscle function in human diseases that range from cancer to heart failure, from arthritis to AIDS. Recent advances have established that TNF-alpha causes muscle weakness via at least two mechanisms, accelerated protein loss and contractile dysfunction. Protein loss is a chronic response that occurs over days to weeks. Changes in gene expression required for TNF-alpha induced catabolism are regulated by the transcription factor nuclear factor-kappaB which is essential for the net loss of muscle protein caused by chronic TNF-alpha exposure. Contractile dysfunction is an acute response to TNF-alpha stimulation, developing over hours and resulting in decreased force production. Both actions of TNF-alpha involve a rapid rise in endogenous oxidants as an essential step in post-receptor signal transduction. These oxidants appear to include reactive oxygen species derived from mitochondrial electron transport. Such information provides insight into the cellular and molecular mechanisms of TNF-alpha action in skeletal muscle and establishes a scientific basis for continued research into cytokine signalling.

Publication Types:

Review
Review, Tutorial
PMID: 11412134 [PubMed - indexed for MEDLINE]
 
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I've bought it in bulk powder form from them and in capsule form from lef a few times. But I take it for the anti-cancer/antioxidant effects. Problem is that it is not well-absorbed unless taken with bioperine mentioned above. BAC sells this for $2/gram and the lef brand has bioperine already added. As far as I can tell, the above study is the first one ever done on curcumin and muscle regeneration.
 
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