Genetic disposition and doses/duration of steroids used are probably the biggest factors, but I still don't think it warrants the use of a prescription drug to counteract the effects the AAS has on cholesterol. You are basically using one drug to combat the sides of another yet again which is probably uncecessary unless you have a history of bad cholesterol to begin with. I would almost always use a combination of policosanol, odor-controlled garlic caps, and hawthorn berry mid-through post cycle. My LDL once shot up from 156 to 202 on a 12-week sust/deca/dbol, and after just 6 weeks of 10mg policosanol ED it dropped down to 172. I'm sure had I run the herbals straight through it would have never been an issue. Cardiac health is the biggest concern for AAS users, so it would make sense to take as many precautions as possible IMO.