I posted this on cuttingedgemuscle and Nandi12 reckons it could since it increases the estrogen to androgen level according to him!
Although to my knowledge it has not been documented in the medical literature specifically for Proviron, there is a well established mechanism whereby drugs that bind strongly to SHBG can cause gyno. Both estrogen and testosterone circulate bound to SHBG; however estrogen is bound much less strongly than testosterone, so agents like Proviron preferentially displace estrogen rather than testosterone from SHBG, leading to higher circulating levels of free estrogens. This phenomenon is discussed here:
http://www.endotext.org/male/male14/male14.htm
DISPLACEMENT OF ESTROGENS FROM SHBG
Another cause of gynecomastia from estrogen excess includes steroid displacement from sex-hormone binding globulin (SHBG). SHBG binds androgens more avidly than estrogen. Thus, any condition or drug that can displace steroids from SHBG, will more easily displace estrogen, allowing for higher circulating levels of estrogen.
People`s opinon?
Although to my knowledge it has not been documented in the medical literature specifically for Proviron, there is a well established mechanism whereby drugs that bind strongly to SHBG can cause gyno. Both estrogen and testosterone circulate bound to SHBG; however estrogen is bound much less strongly than testosterone, so agents like Proviron preferentially displace estrogen rather than testosterone from SHBG, leading to higher circulating levels of free estrogens. This phenomenon is discussed here:
http://www.endotext.org/male/male14/male14.htm
DISPLACEMENT OF ESTROGENS FROM SHBG
Another cause of gynecomastia from estrogen excess includes steroid displacement from sex-hormone binding globulin (SHBG). SHBG binds androgens more avidly than estrogen. Thus, any condition or drug that can displace steroids from SHBG, will more easily displace estrogen, allowing for higher circulating levels of estrogen.
People`s opinon?