Arimidex works against estrogen. Some products like deca and fina trigger the progesterone receptor and have little to no effect on estrogen. Thats why for certain products, arimidex, liquidex, nolva, etc do you no good. In simple terms Winny can attach to the progesterone receptor, but does not activate it, thereby potentially blocking progesterone related sides that may be caused by the progesterone affecting AAS.