Re: ANDROSTENEDIONE, NORANDROSTENEDIONE, AND ANDROSTADIENEDIONE!
Posted by PA on March 25, 1997 at 10:54:54:
In Reply to: Re: ANDROSTENEDIONE, NORANDROSTENEDIONE, AND ANDROSTADIENEDIONE! posted by Unique on March 24, 1997 at 22:29:32:
: : : Ok, I've finally got a cheap source for androstenedione. I am getting with George at present
: : : to bring all of you a special deal on this. I want to do a test on norandrostenedione. Whoever
: : : wants to try this for results let me know because I will order some this week as a test. I am
: : : trying hard to see if androstadienedione (gets converted into bolderone (EQ) in the body) is
: : : found anywhere in nature. If it is we will really be rocking!
: : : Keep up the fight
: : : Unique
: : What evidence if any do you have that norandrostenedione occurs in nature?
: : And what evidence do you have that norandrostenedione or androstadienedione are
: : good substrates for 17beta-hydroxysteroid dehydrogenase and will be effectively
: : converted to there respective 17 beta hydroxy derivatives in vivo?
: : PA
: OK, Norandrostenedione occurs NATURALLY in the placenta of pregnant females--this is a well-documented
You better have a reference to back this up. And this sounds like a very weak argument to convince the
FDA of its "natural" status. I spent hours upon hours finding all sorts of plant and animal sources that
show androstenedione is a sufficiently "natural" compound and I am still worried the FDA might not buy it.
Androstadienedione has been found naturally in the urine of an epilectic boy but that is all I've
: been able to find. Norandro. can be brought to the market; I'm not sure about the androstadienedione. Too
: bad about the latter though as it is also a great anti-aromatase.
What reference do you have for this?
Anyway, what evidence of them being a good
: substrate. Well, there really isn't any studies but you have to put two and two together. The hydoxylases are
: pretty nonspecific. It is well documented that androstAnedione gets converted into DHT. Also, if you look at
: the metabolism of a c-19 and its corresponding 19-nor you will see a remarkably similar metabolic fate (pharmokinetics)
: of the drug. Obviously, there are some differences such as the aromatase enzyme but in terms of the hydroxylase there
: is no reason that I can see that it won't convert in sufficient quantities the sister compounds. These compounds are just
: the beginning--there are many others that occur naturally that have efficacy!
: Keep up the fight
17beta HSD is not a hydroxylase unique, it is a reversible oxidation/reduction enzyme. Don't throw around
technical terms unless you know exactly what they mean and they are relevant.
- Re: ANDROSTENEDIONE, NORANDROSTENEDIONE, AND ANDROSTADIENEDIONE! Unique 11:11:46 3/25/97