A||||12||riptchick||Milk Thistle|||||| Z||000000||riptchick||07-30-2000||03:49 PM||riptchick@operamail.com||Lot of talk about milk thistle and liver protection/repair? Is there any studies behind this that are noteworthy regarding effectiveness? Anyone have any information related to when to supplement with this i.e. during cycle, after, always, etc.? Thanks.||152.163.194.203||reg|| Z||000001||MS||07-30-2000||03:57 PM||mad.scientist55@hushmail.com||There are plenty of studies showing improvement in liver enzyme profiles while using milk thistle. This may or may not translate to liver protection, but it is still probably a good idea to use it if you're taking orals or drinking alcohol, etc.....The liver gets a hard time in our modern living conditions. Why not take it all the time? To answer my own question, I guess there have not been any studies on the long term effects of consuming milk thistle.||139.80.64.4||reg|| Z||000002||riptchick||07-30-2000||04:26 PM||riptchick@operamail.com||Thank you, MS. Your insight is always helpful.||152.163.194.187||reg|| Z||000003||skydancer||07-30-2000||05:42 PM||skydancer43@hotmail.com||Now this is interesting..I agree MS - these are some hard environmental times on our bodies...does anyone know if fresh tea is as good as any other way to take milk thistle?

I've also read that dandelion is good for assisting the liver - but that it may (Oh NO) increase appetite? Any thoughts?

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Patience is a bitter plant, but it has sweet fruit.

||207.114.212.94||reg|| Z||000004||fitness-for-life !!||07-30-2000||06:27 PM||gibbsc@polaroid.com|| Milk Thistle has been used for over 30 years in England. No side effects, used to help cleanse the liver..||216.41.29.22||reg|| Z||000005||MS||07-30-2000||06:37 PM||mad.scientist55@hushmail.com||Silymarin/silybilinin are the active components of milk thistle (so you don't have to drink the tea). These are very exciting compounds. Not only are they strong antioxidants that can protect against or improve hepatitis, but they also show a lot of potential in the treatment/prevention of diseases such as cancer, arthritis and other inflammatory conditions. This is why I personally think it's a good idea to include them in your supplement regime along with all your other antioxidants.

Much of the research is in early stages, but definitely encouraging.||139.80.64.4||reg|| Z||000006||BigPappa||07-30-2000||10:05 PM||||LIV52 is the best. Russians gave it in the 70s to their roided up juice monkeys. Don't know if its available domestically...I get mine from international source.||63.21.88.104||reg|| Z||000007||riptchick||07-30-2000||10:15 PM||riptchick@operamail.com||Liv52 huh? I'll have to see if I can find that. ||152.163.201.201||reg|| Z||000008||MS||07-31-2000||05:27 PM||mad.scientist55@hushmail.com||MILK THISTLE (Silybum marianum)

The liver is the most important organ of metabolism. Disruption of normal liver function results in significant disruption
of all metabolic processes. The metabolic functions of the liver include regulation of carbohydrate, fat and protein
metabolism, storage of vitamins and minerals, and detoxification reactions.Since the liver is the major site of
detoxification of toxic chemicals in the body, it is also at a very high risk against damage by such chemicals as DDT;
dioxin; 2,4,5-T; 4-D; PCB; and PCP. It is not known to what degree Americans are exposed to these toxic
compounds, but it is probably quite high as yearly production of synthetic pesticides alone exceeds 1.4 billion
pounds. In addition, many drugs and alcohol are also known to damage the liver.

Avoidance of these damaging chemicals is the first defense against liver damage. The second defense may be the use
of a Silymarin Comples. Silymarin Comples is composed of concentrated extracts of herbs which have demonstrated
remarkable effects in protecting the liver from chemical damage and in improving liver function in experimental
studies. Milk Thistle consists of three powerful liver-protective flavonoids. These flavonoids, silybin, silydianin, and
silychristin, are usually referred to as silymarin.

The common milk thistle contains some of the most potent liver-protecting substances known. The concentration of
these components is highest in the fruit. Silybum's effect of preventing liver destruction derives from its ability to
inhibit those factors that are responsible for the damage. Liver destruction occurs primarily as a result of certain
toxins producing or acting as free radicals: highly reactive compounds that damage other molecules. Silybum
components prevent free radical damage by acting as antioxidants.These components are many times more potent in
antioxidant activity than Vitamin E.

Another way in which the liver can be damaged is by the action of leukotrienes. These compounds are produced by
the transfer of oxygen to a polyunsaturated fatty acid. This reaction is catalyzed by the enzyme lipoxygenase. Silybum
components inhibit this enzyme, thereby inhibiting the formation of damaging leukotrienes.

Perhaps the most interesting effect of silybum components on the liver is their ability to stimulate protein synthesis.
The result is an increase in the production of new liver cells to replace the damaged old ones. Not only can silymarin
protect liver cells, it can regenerate already damaged ones. Additionally, silymarin was shown to increase liver,
stomach, and intestinal glutathione This common herb's value against liver disease has been demonstrated in more
than 100 rigorous scientific experiments. Unfortunately, the vast majority of these studies has been European, mostly
German, and few mainstream American physicians read German botanical medicine journals. As a result, they are in
the dark about milk thistle's astonishing liver-protective powers.

Silymarin is not very soluble in water, which means that very little find its way into a tea made from the milk thistle
plant. It is also poorly absorbed from the digestive tract, which severely limits its bioavailability from tinctures
because they are not sufficiently concentrated to deliver a therapeutic dose. To rectify this problem, German
researchers bred a special variety of milk thistle. When carefully cultivated, this medicinal variety produces a
high-potency standardized extract of silymarin, which is processed into tablets or capsules. This standardized milk
thistle seed extract is 80-percent silymarin. It is widely prescribed by German physicians, who practice the world's
most advanced scientific herbal medicine.

How Silymarin Works

Silymarin works in three ways. It strengthens the outer membranes of livercells, preventing penetration by
liver-damaging substances.

Silymarin also protects liver cells because of its powerful antioxidant action. Antioxidants neutralize cell damage
caused by chemically unstable oxygen molecules caused by a high-fat diet, smoking, and other toxic substances. The
best known antioxidants are vitamin A (beta-carotene), vitamin C, vitamin E, and the mineral selenium. However, in
the liver,silymarin is more than ten times as potent an antioxidant as vitamin E.As far as scientists know, silymarin
does not interfere with the liver's metabolism of drugs, so it does not interfere with the action of medications. Anyone
who drinks alcohol or takes any medication -- either prescription or over the counter drugs -- boosts the liver's
workload, and damages some liver cells in the process. Fortunately for all of us, the liver is quite large. It's the
second largest organ, after the skin, so you can lose millions of liver cells and still function normally. But why lose
even a single liver cell if you don't have to?||139.80.64.4||reg|| Z||000009||riptchick||08-01-2000||10:43 AM||riptchick@operamail.com||GREAT INFO!||152.163.201.202||reg|| Z||000010||Artemis||08-01-2000||11:09 AM||huntress@operamail.com||How difficult is it to cultivate this stuff?||131.104.100.160||reg|| Z||000011||MS||08-01-2000||02:56 PM||mad.scientist55@hushmail.com||Ordinary milk-thistle is VERY easy to cultivate. I don't know about the european variety with high silymarin though. Around these parts milk-thistle is a weed! Geesh. But it's low potency stuff. The standardized extracts are pretty expensive, which means either someone has a corner on the market, or it's not cheap to grow and extract. ||139.80.64.4||reg|| Z||000012||Superstar2b||08-01-2000||03:05 PM||klopatowski@northpoint.net||Doesn't evening primrose oil also protect the liver? My boyfriend uses this while on goodies. Should he switch to milk thistle instead?||63.251.252.4||reg||