GHRP-6 and Hexarelin
Recently, Anthony Roberts was interviewed by a major online bodybuilding site (the interview was titled “Chemically Insane”), and in that interview, he predicted that various peptides would become the newest trend in performance enhancing drugs. For the most part, he was correct, and now they’re very popular and widely available, although still relatively new. Here’s his article on GHRP-6 and Hexarelin
So, several months ago, I began my experimentation with various peptides, mostly with the goal of figuring out the best way to use them. My last major article examined my experiences with the two most popular peptides (IGF and MGF) currently on the market. This time around, I’m going to tell you about my experience with Hexarelin and GHRP-6, two lesser known peptides. With Lr3IGF-1, the use and goals of use is pretty straightforward... you pretty much use it to gain muscle and lose fat; on rare occasions, people use it to rehab an injury (I actually provided a full rehab protocol using IGF-1 in my first e-book). With MGF, it’s even simpler... you use it to increase muscle size, period.
Using the other peptides is a bit more complicated, and there are a couple of other reasons you might want to consider using them... but I’m getting a bit ahead of myself. The first thing I do when I’m researching a new anabolic is to jump on the internet and do some research in all of the available medical databases, and exhaust every search engine imaginable with keywords related to the new compound. The next thing I do is typically to get a couple of vials and try it for myself. I’m in a very unique position with regards to trying new compounds; in the case of several compounds (Esterless Boldenone, Masteron Enanthate, Stealth Injectables, etc...) I was actually able to try the products before they were released to the general public. In the case of Hexarelin and GHRP-6, I have had the opportunity to experiment with them for the past few months.
When I first received my vials of GHRP-6 and Hexarelin, I did what most people probably do... I reconstituted them, shot first, and asked questions later. I thought it would be a great idea to fire up 600mcs of GHRP-6 just before a heavy max effort deadlift session. Bad idea. I have a 45 minute drive to my gym (I happen to workout at a military academy, where I coach), and halfway there, I started to get a bit hungry. No problem, right? We’ve all worked out a bit hungry... well, that’s what I thought at first. Then when I hit about 400lbs into my deadlifts, I started getting dizzy... I broke into a cold sweat, and I had to sit down. I rushed to get some simple carbs into my body as quickly as possible, thinking that I was going hypoglycemic. Ok... I wasn’t going hypoglycemic, but it was pretty bad. That workout was shot. Still, I was wondering if I could actually slip into some kind of severe hypoglycemia from a shot of GHRP-6... it certainly felt like I could.
So, naturally, I was interested, and did some experimenting. I waited a day and invited a friend over to my place... then I did another shot of 600mcg (split bilaterally, 300mcg into each leg, as a subcutaneous shot). Then we sat around and waited, with a bunch of simple carbs ready. I got hungry, I was uncomfortable, and it wasn’t too much fun, but we sat there for a good couple of hours, and I didn’t pass out (in case you’re wondering, the friend was there to drive me to the hospital, in case I actually did pass out). Ok... so that settles that. Originally, I thought that maybe GHRP-6 operated by inducing some kind of mild hypoglycemia (hypoglycemia increases GH output). But that’s not how it actually works...
Growth Hormone Releasing Peptide- 6 (GHRP-6) is a synthetic hexapeptide which stimulates the release of Growth Hormone. It accomplishes this by two totally separate mechanisms. On the one hand, it amplifies your body’s natural Growth Hormone Releasing Hormone (GHRH) signal transduction pathway, and on the other hand, acts as a functional antagonist of the hormone which causes inhibition of GH secretion (somatostatin) (1-3).
GHRP-6 also has the benefit of being able to directly stimulate the anterior pituitary gland, resulting in increased GH release. So although my initial thoughts on the mechanism of action for this stuff was wrong, I was enthused when my research revealed that GHRP-6 induced GH secretion occurs by several mechanisms. Most importantly, those mechanisms are the induction of GHRH release from the hypothalamus, stimulation of GH release from somatotrophs, joint actions of GHRH and antagonism of somatostatin, and finally by pronounced antagonism of somatostatin action on somatotrophs (1-4). However, it bears clarification that GHRP-6 is not dependant on the GHRH pathway... it can boost your growth hormone levels without necessarily needing to elevate GHRH. This is important because if that pathway has been inhibited by long term GH use, GHRP-6 can still get your body producing and releasing GH.
Additionally, this peptide can also act on the central nervous system, (4) which can provide added benefits in neuroprotection as well as muscular strength increases for the user. Much of the strength increases we see with Anabolic Steroids in the Dihydrotestosterone family are suspected to be through a similar stimulation of the Central Nervous System. In my experience with GHRP-6 use, strength levels typically go up within the first week of starting out.
Increases in Growth Hormone levels in the body are typically accompanied by strength increases, muscle hypertrophy (growth), and lipolysis (fat loss). Other results experienced with increased GH levels are recuperative effects on joints and injuries; connective tissue strengthening and bone mineral density improvements are commonplace. Enhanced GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the primary anabolic mechanism of action for Growth Hormone. In the case of GHRP-6, I gained quite a bit of weight when I was running it at the 600mcg/day level. I think that this was probably due to overfeeding that almost always accompanied my shot contributed to this weight gain. I gained about 12lbs in 2 weeks. I think that the same way people often throw EQ into bulking cycles to increase appetite stimulation, I would suggest using GHRP-6 instead. It’s not anywhere near as anabolic, but the appetite increase is far above anything I’ve ever experienced with any anabolics.
The women I know who have used GHRP-6 all had to discontinue its use because it was making them gain weight too quickly. But then again, most of the women who I know are national level (or professional) physique competitors, and at most need an additional 5-10lbs of muscle at most. GHRP-6 just put too much weight on them too quickly.
After experimenting with GHRP-6 for weight gain, I lowered the dose substantially and used it to help rehab a knee injury that had been bothering me for a couple of years. In this case, I lowered it to 100mcg/day, shot sub-q into the knee (ouch!). At this dose you won’t find the extreme hunger that a high dose of it usually causes, and a 5mg bottle of GHRP-6 is going to last for months, and I’m confidant that it’s going to be enough to rehab virtually any injury (in my case, I had done extensive damage to my knee over the years, culminating in a traumatic injury playing on turf... which resulted in my semi-retirement from competitive athletics). Anyway, I combined GHRP-6 with a knee rehab protocol designed by Eric Cressey, M.A. C.S.C.S., and advice from one of my research assistants, who has a degree in Sports Medicine. Taken this way, I used GHRP-6, and rehabbed my knee to almost where it was prior to my beginning my career in athletics. If you have an injury, find yourself a good rehab protocol, and try a low dose of GHRP-6. I bet you’ll be surprised.
Oh... and this brings me to another point. I’m sure most people subscribe to the theory that peptides only last for a couple of weeks in their reconstituted form. Well, after I had my GHRP-6 reconstituted for well over a month, I tried a shot at my old 600mcg dose, and guess what happened? Yeah, I got a huge increase in appetite within the hour. This tells me that we’re really underestimating the amount of time that a reconstituted peptide can retain its potency. I’m betting we have months, not weeks.
Since GHRP-6 acts directly on the feedback loop which signals the inhibition of GH release, it has been used immediately following either GH or IGF-1 cycles, to recover natural GH production by inhibiting somatostatin action. It has also been used concurrently with those compounds to negate some of the effects of those compounds on natural GH production. Most people who use IGF never actually realize that as IGF is part of the hormonal cascade that GH initiates, it is also part of the Negative feedback loop for it.
Typical doses of GHRP-6 range from 100mcg/day injected subcutaneously (for connective tissue strengthening) to 500mcg/day (for an anabolic effect). After experimentation with a wide variety of doses, and input from several people who have also used the product, I think that 500mcg/day is the upper limit of effective dosing for GHRP-6.
The most rapid side effect experienced with GHRP-6 is extreme hunger, which typically occurs within an hour of injection. This could be due to a possible effect on blood sugar lowering, or more likely (I suspect) due to its influence on Ghrelin (5), stimulated by the peptide influenced release of GH. Ghrelin, by the way, increases appetite and speeds gastric emptying. This means... even if you weren’t hungry a second ago, and your Ghrelin levels go up too much... you’ll be starving soon.
If I were looking to figure out the best way to use GHRP-6 in a bulking cycle, I would simply take my favorite bulking cycle, and run GHRP-6 with it at a daily dose of 600mcg/day, shot post-workout. The reason for the post-workout dosing is to take advantage of the appetite stimulating properties, at the same time as taking maximum advantage of the anabolic properties of the GH release that it will cause. And I’d probably consider using some insulin as well, because insulin is highly anabolic on its own, but also because the GH response to GHRP-6 is elevated with concurrent use of insulin (6). Again, this is only how I’d do it personally, and I’m sure people will experiment with things and find the optimal way to get the results they want on an individual basis. GHRP-6 and this is no exaggeration, will put as much weight on you as nearly any steroid. If you’re not careful, you’ll gain too much fat... my recommendation is to use this stuff on your off season bulking cycles.
Overall, I was pretty impressed with GHRP-6, in my experience with it. Its ability to put weight on me was actually too potent, although the strength gains were nice. Now, I’ll mostly use GHRP-6 for post cycle therapy from IGF use, or when I need to get rid of an injury.
I’ve never used Growth Hormone (let’s face it... it’s expensive, and Lr3IGF-1 + MGF is a much better buy), but when I used Hexarelin, I experienced most of the results that GH users report, but in much less time. Out of the two GH secretagogues that I tried (Hexarelin and GHRP-6), Hexarelin is definitely my favorite. In my own personal case, I’m 28 years old right now, and not looking to add any more mass. I can comfortably maintain my bodyweight with my doctor-prescribed anabolics (I’m on permanent Hormone Replacement Therapy), and now I mostly focus on athletic-oriented goals. So strength gains without much weight, and maybe a bit of bodyfat loss, are my primary concerns. If I were in my early 20’s and still looking to gain weight, I’d probably be in love with GHRP-6, but for this stage of the game, I prefer the effects I’ve found with Hexarelin.
Hexarelin is a GH secretagogue, specifically a hexapeptide which stimulates the release of growth hormone (GH) in both GH deficient as well as normal humans. When given by injection, plasma growth hormone concentrations increased (with a dose-dependent response curve). Growth Hormone levels peak at the half-hour mark after injection, then decreasing to baseline values within roughly four hours (half-life is about 55 minutes). (7)
Of course, as we know from other peptides like GHRP-6, this type of surge in Growth Hormone levels has been positively correlated with increases in strength, muscle hypertrophy, and fat loss. Therefore, the many advantages of having GH secreted in larger amounts via administration of Hexarelin are comparable to the effects of injectable growth hormone administration. In my own case, I found that Hexarelin increased my strength and even aided with fat-loss a bit, but didn’t put much weight on me at all. This makes it very different from GHRP-6, which piles tons of weight on me.
Although my knee injury was, for the most part, totally healed from my use o GHRP-6, I suspect that Hexarelin would have produced very similar results or that purpose. That’s because, as we already know, increasing GH levels elicits a favorable increase in bone mineral density. When I used Hexarelin, however, I was mostly interested in the increase in GH which would provide me with both increased mitosis and meiosis (each of which leads to hypertrophy, i.e. increased muscle size), triglyceride hydrolysis which helps aid in fat loss. And since there are GH receptors (though no IGF-1 receptors) in adipose tissue, I decided to use my Hexarelin subcutaneously in my abdomen. Even though the GH response is systemic (whole-body), it couldn’t hurt to concentrate the shots where fat is more highly concentrated (which in males is the abdomen). I used 200mcg/day of Hexarelin, shot sub-q (in my case, being under 100kgs, this is just slightly over the maximum response dose...as I later found out).
Hexarelin enhanced GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor 1). IGF-1 is thought to be the primary causative factor in the anabolic effects of Growth Hormone. It needs to be noted at this point that data on this is actually conflicting, and I’ve seen studies where (somehow?) Hexarelin elicits a release in GH without a commensurate increase in IGF-1 levels. In my own experience with Hexarelin, I found it to be reasonably anabolic on its own, and think that the
But lets be realistic here; it’s important to realize that Hexarelin is not going to produce results similar to high dose GH cycles, in the normal person. This is because Hexarelin only stimulates the increase of GH, and has been found to be effective up to 2mg/kg, but after that dose does not really produce more results in terms of GH secretion (7). Thus, a dose of 2mgs/kg is the upper limit for Hexarelin use, while GH users in the professional ranks of athletics and bodybuilding have gone as high as 10iu/day. Hexarelin, at 2mg/kg of bodyweight has been compared by most users to the type of results seen with 1-2iu/day of GH. At the price, though, Hexarelin is a much better alternative. If you need the type of results that 3iu+/day of GH are going to give you, then that’s an impossibility with Hexarelin use. Still, for the price and for the effects, this stuff is a steal when compared with using 2iu of GH every day.
One of my powerlifter friends (read: Lab Rats), who assists me in some of my research used Hexarelin while training for a meet. He had the dual purpose of rehabbing a shoulder as well as trying to increase his bench press. As you probably could have guessed, his bench went up, and his shoulder seemed to have healed. He was using roughly half the dose of Hexarelin I recommend for hypertrophy and fat loss, which worked out to about 50mcg/day shot 2x a day in the injured shoulder. His shoulder healed up nicely, and his strength went up a bit. Neither myself nor my friend had any increased appetite on Hexarelin, and I suspect that this is because it has a much less profound effect on Ghrelin levels. The strength gains we both received from its use were very similar to those experienced with GHRP-6, but with very little weight gain, and negligible fat loss. Hexarelin is a nice addition to a cutting cycle, to make maximum use of the GH response to both anabolic steroids as well as the GH induced response from training. And, it never hurts to include something that’s going to help your joints on a cutting cycle, since we know that the typical compounds used in a cutting cycle (Winstrol, etc... ) often cause joint problems. We can use the added GH from the Hexarelin to help protect our otherwise compromised joints on a cycle, without spending tons of money on GH.
Unlike GH, however, some attenuation to Hexarelin occurs by week 4, and continues on up to 16 weeks of use. By separating Hexarelin cycles by 4 week off periods, this attenuation can be totally reset, (9) and the next cycle of Hexarelin will produce the same level of results as the first cycle. During a cutting cycle, I recommend using Hexarelin for the weeks where compounds such as Winstrol are used, and continuing its use for the duration of the cycle. If you’re using Lr3IGF-1 on your cutting cycle, then I recommend saving the Hexarelin for after the IGF use is over.
Although, many athletes use Hexarelin alone, others have used it after a Growth Hormone or Insulin-Like Growth Factor one cycle, to as a form of Post-Cycle Therapy for the recovery of their own natural GH and IGF-1 production. Again, for this purpose, 2mg/kg, injected subcutaneously is the proper dose per day.
Although they’re new, and haven’t been experimented with too extensively in the bodybuilding community, I think that both GHRP-6 and Hexarelin will be used more commonly in the coming months and years. It took me far too long to jump on the bandwagon with IGF, and I was far too slow to begin my personal experimentation with MGF, so when these two peptides became available to me, I didn’t want to let the opportunity go for too long. Now, after some pretty extensive personal experimentation with these two peptides, I think that Hexarelin is a great anabolic addition to a cutting cycle, and GHRP-6 is probably the most potent (non-steroid) weight gainer that I’ve ever used. Considering the price, legal status, and availability, these two are probably going to find their way into quite a few cycles over the next few years.
Anabolic steroid profile courtesy of GearProfiles.com.
Primobolan Depot, although with a weaker effect than Deca Durabolin, is a good basic steroid with a predominantly anabolic effect and, depending on the goal, can be effectively combined with almost any steroids. Those who would like to gain mass rapidly and do not have Deca available, can use Primo-Depot together with Sustanon and Dianabol (D-bol). Those who have more patience or are afraid of potential side effects will usually be very satisfied with a stack of Primobolan-Depot 200 mg/week and Deca Durabolin 200- 400 mg/week. We believe that the best combination is Primobolan Depot with Winstrol Depot. 200 - 400 mg/week is the normally used dosage of Primobolan Depot although there are enough athletes who inject a 100 mg ampule daily. Primobolan Depot, like the oral acetate form, is not converted into estrogen however, low water retention can occur, which is the reason why during preparalions for a competition the injections are usually preferred.
Side effects with Primobolan Depot are minimal and manifest themselves only rarely and in persons who are extremely sensitive.
Due to the androgenic residual effect, side effects include light acne, deep voice or increased hair growth. Primobolan Depot has even less in fluence on the liver function than the oral form so that an increase of the liver's toxin values is extremely unlikely.
The blood pressure, cholesterol level, HDL and LDL values, as with Primo tablets, usually remain unaffected. Primobolan Depot is generally the safest injectable steroid. Athletes whose liver values strongly increase when taking anabolic steroids but who still do not want to give up their use, under periodical supervision of these values, can go ahead and try a stack of Primobolan Depot, Deca Durabolin, and Andriol. A well-known bodybuilder in Germany who had already won several national titles has admitted that his liver was damaged by his too frequent use of the 17-alpha alkylated steroids Dianabol (D-bol), Anadrol (at the time still Plenastril), and Anavar. He was,however, able to bring his body back to national championship level by taking 200 mg Primobolan-Depot/week, 400 mg Deca Durabolin/week, and 240 mg Andriol/day, without a negative effect on the liver values.
Primobolan Depot, like the tablets, has only a very small influence on the hypothalamuhypophysiat testicular axis so that the body’s own testosterone production is only reduced when very high dosages are taken over a prolonged period of time.
100 mg Primobolan Depot/week, combined with 50 mg Winstrol Depot/week, is usually an effective stack for many women and is tolerated well so that virilization symptoms are rarely observed.
To avoid an undesired accumulation of androgens in the body women should pay attention that there are three to four days in between the relative injections. For competing female athletes this stack, however, is too weak. Primobolan Depot is often used in a dose of 100 mg/week to bridge over steroid breaks which, in our opinion, is not a good idea: The non-stop use of anabolic steroids has a strong negative influence on the body’s own testosterone production and prevents the body from normalizing its functions. Dosages as low as 100 mg Primobolan Depot per week or 5O mg Deca Durabolin per week (also uften used for bridging) are non-toxic and mostly have no side effects. However, the effectiveness of such an intake must be strongly doubted since both sompounds in in this dosage are much too weak in order to effectively counteraffect the catabolic phase which begins in the steroid phases. Better results can usually be obtained with Clenbuterol without influencing the hormone system.
Those who believe that in the "steroid free time" they must still take some "stuff" to bridge the usages should inject the long acting Testosterone enanthate (e.g. Testoviron Depot 250mg/ml) every two to three weeks.
The Spanish, Belgian, Greek, and German Primobolan Depot sell for approximately $ 15 per ampule. A Mexican version is also available but only in the 50 mg strength. Special attention must be paid to the fact that the injection solution of the original Spanish Primobolan is included in an ampule of brown glass with a red imprint burnt into the glass, and not in normal window glass as is common in other countries. The Mexican version is also in brown glass but the label is blue. When the package is opened a clear plastic bed is visible which, on the other side, is coated with aluminum foil and has the "Primobolan Depot" imprint on its surface. So far, according to our knowledge, there are no fakes yet. There are more or less good fakes of the other versions."
Yours in sport,