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Will Nolvadex help with Deca gyno?
- Thread starter CyBeRoiDs
- Start date
Nolva will not help with Progesterone induced gyno(the gyno caused by Deca) Winsrol and RU-486 are the only things(that I know of) that will help. Good Luck!
M18
M18
solidspine
New member
I'm going to Mexico ASAP an I will see if it is actually available, I think so. 
Weam
New member
Nolvadex will help a little with Deca gyno,
first Deca-durabolin cause Gyneacomastia by two different ways
first Deca classified as a Progestin (19-nor Progesterone) which have a Progesterone like activity and it will bind to Progesterone receptors at beast tissues to cause gyneacomstia
second, Deca classified as a 19-nor Testosterone therefor it will never aromatise as it lacks carbon at the 19 position of the molecule but Deca-durabolin converts to Estrogen not with the random aromatising process but throw the action of organic acids or alkalines in the body that act on nandrolone after it is converted to its 1-beta hydroxylated derivative
Winstrol or RU-486 for stopping the first case
and Nolvadex only for stopping the second case
You can't use any anti-aromatise drugs as it will be just a waste of money, Estrogen receptors blockers as Nolvadex is the best for preventing Estrogen gyno while using Deca
first Deca-durabolin cause Gyneacomastia by two different ways
first Deca classified as a Progestin (19-nor Progesterone) which have a Progesterone like activity and it will bind to Progesterone receptors at beast tissues to cause gyneacomstia
second, Deca classified as a 19-nor Testosterone therefor it will never aromatise as it lacks carbon at the 19 position of the molecule but Deca-durabolin converts to Estrogen not with the random aromatising process but throw the action of organic acids or alkalines in the body that act on nandrolone after it is converted to its 1-beta hydroxylated derivative
Winstrol or RU-486 for stopping the first case
and Nolvadex only for stopping the second case
You can't use any anti-aromatise drugs as it will be just a waste of money, Estrogen receptors blockers as Nolvadex is the best for preventing Estrogen gyno while using Deca
BigBazooka
New member
Weam said:
i'm hoping some mods to reply this also.
The_Eviscerator
New member
Nolvadex will help with Deca Gyno, the whole progesterone myth is nothing more. Read some of Bill LLewellyn for more on this issue.
Deca is not aromatized to progesterone. (Progesterone lacks the phenolic structure in the A ring, so is not the product of aromatization.) Deca is however aromatized to estrogen (1) (2), .
Deca binds to the progesterone receptor (3), but whether progesterone has a direct role in gynecomastia is unknown. It is thought that it acts indirectly by stimulating prolactin secretion. How this occurs is not known. Since prolactin is thought to be the ultimate culprit, prolactin inhibitors such as bromocriptine will prevent and/or reverse prolactin induced gynecomastia.
There are no studies confirming winstrol prevents gyno, although it is possible since in certain tissues it binds to the progesterone receptor as an antagonist. It does not do this in all tissues, and there are no studies showing it binds in breast tissue.
Im am not aware of any studies that show RU-486 (mifepristone) prevents or treats gyno. In fact, in patients that have been treated with mifepristone for Cushing's disease, gynecomastia has been reported as a side effect (4)
(1) J Steroid Biochem 1989 Nov;33(5):949-54
Androgen and 19-norandrogen aromatization by equine and human placental microsomes.
Dintinger T, Gaillard JL, Moslemi S, Zwain I, Silberzahn P.
(2) 1: Nippon Naibunpi Gakkai Zasshi 1986 Jan 20;62(1):18-25
[Aromatization of androstenedione and 19-nortestosterone in human placenta, liver and adipose tissues]
Yoshiji S, Yamamoto T, Okada H.
(3) Methods Find Exp Clin Pharmacol 1997 May;19(4):215-22
Estrogenic and progestagenic activities of physiologic and synthetic androgens, as measured by in vitro bioassays.
Markiewicz L, Gurpide E.
(4)http://www.endocrinology.med.ucla.edu/cushing's_syndrome.htm
Deca binds to the progesterone receptor (3), but whether progesterone has a direct role in gynecomastia is unknown. It is thought that it acts indirectly by stimulating prolactin secretion. How this occurs is not known. Since prolactin is thought to be the ultimate culprit, prolactin inhibitors such as bromocriptine will prevent and/or reverse prolactin induced gynecomastia.
There are no studies confirming winstrol prevents gyno, although it is possible since in certain tissues it binds to the progesterone receptor as an antagonist. It does not do this in all tissues, and there are no studies showing it binds in breast tissue.
Im am not aware of any studies that show RU-486 (mifepristone) prevents or treats gyno. In fact, in patients that have been treated with mifepristone for Cushing's disease, gynecomastia has been reported as a side effect (4)
(1) J Steroid Biochem 1989 Nov;33(5):949-54
Androgen and 19-norandrogen aromatization by equine and human placental microsomes.
Dintinger T, Gaillard JL, Moslemi S, Zwain I, Silberzahn P.
(2) 1: Nippon Naibunpi Gakkai Zasshi 1986 Jan 20;62(1):18-25
[Aromatization of androstenedione and 19-nortestosterone in human placenta, liver and adipose tissues]
Yoshiji S, Yamamoto T, Okada H.
(3) Methods Find Exp Clin Pharmacol 1997 May;19(4):215-22
Estrogenic and progestagenic activities of physiologic and synthetic androgens, as measured by in vitro bioassays.
Markiewicz L, Gurpide E.
(4)http://www.endocrinology.med.ucla.edu/cushing's_syndrome.htm
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