Thanks, X, but I didn't know it could be affected per injection site. When I first started HRT, my levels were 76 ng/dl, very low. The doc put me on 200mg. every 2 weeks, ran out of steam after 7-8 days. Showed her per Internet article from several endo docs about the once a week @ 100mg. After I started that regimen, it leveled out. BTW, I do quad injections. JB