ED keeps it more stable in my blood... but not much different as far as gains... if you are using rotating sites you should be good... mid delt x2, rear deltx2, tris×2, bisx2 glutesx2 when arms need a break... I don't even feel the injections in my arms, I also pin up to 15x daily with peps, growth, slin, aas... So I guess you get use to it... also helps if you have someone that can pin you ed for those tough to reach spots and after workouts where the body is tight...