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thommy
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Age-Related Thermogenesis
Age-related declines in the energy homeostat manifest as increased fatigue and reduced energy.3 Increases in obesity, diabetes, atherosclerosis, hypertension, depression and fatigue are just a few of the physiological and psychological problems that accompany decreased energy production with advanced age. Humans are dependent upon thermogenesis as the primary mechanism for heat production and thermoregulation. Metabolic heat, generated from the beta-oxidation of fatty acids mobilized from triglyceride stores, is mediated by interscapular brown adipose tissue (BAT). This metabolic generation of heat is induced by the actions of norepinephrine as well as the body’s response to cold. Animal studies have shown that thermogenesis drops significantly with advanced age. In one study researchers measured both cold- and norepinephrineinduced BAT nonshivering thermogenesis in male Fischer 344 rats. Of particular interest was the finding that the age-related decline in thermogenesis, while pronounced in male rats, was not so great in females.4 The researchers speculate that the observed decline in thermogenesis is due to a drop in the beta-oxidation of lipids by brown adipose tissue. The fact that the older animals have less functional BAT than do their younger counterparts disposes them to increased accumulation of body fat and may explain why men experience sudden weight gains after age 40.
Potassium Salicylate
is a natural source of salicylic acid, which acts like aspirin in the body to stimulate increased thermogenesis and fat burning.13 Salicylic acid increases the thermogenic actions of ephedrine and caffeine by inhibiting feedback control mechanisms that block higher levels of thermogenesis. The combination of a salicylate compound, ephedrine and caffeine has produced close to five pounds a week of weight loss without dieting.14 In one study researchers found that people taking salicylate in conjunction with ephedrine and caffeine lost three times as much weight as those taking a placebo (4.8 pounds vs 1.5 pounds).15 In animal studies, the increase in energy expenditure found during treatment with ephedrine alone was doubled, and the obese group lost greater than 75% of body fat.16
Age-related declines in the energy homeostat manifest as increased fatigue and reduced energy.3 Increases in obesity, diabetes, atherosclerosis, hypertension, depression and fatigue are just a few of the physiological and psychological problems that accompany decreased energy production with advanced age. Humans are dependent upon thermogenesis as the primary mechanism for heat production and thermoregulation. Metabolic heat, generated from the beta-oxidation of fatty acids mobilized from triglyceride stores, is mediated by interscapular brown adipose tissue (BAT). This metabolic generation of heat is induced by the actions of norepinephrine as well as the body’s response to cold. Animal studies have shown that thermogenesis drops significantly with advanced age. In one study researchers measured both cold- and norepinephrineinduced BAT nonshivering thermogenesis in male Fischer 344 rats. Of particular interest was the finding that the age-related decline in thermogenesis, while pronounced in male rats, was not so great in females.4 The researchers speculate that the observed decline in thermogenesis is due to a drop in the beta-oxidation of lipids by brown adipose tissue. The fact that the older animals have less functional BAT than do their younger counterparts disposes them to increased accumulation of body fat and may explain why men experience sudden weight gains after age 40.
Potassium Salicylate
is a natural source of salicylic acid, which acts like aspirin in the body to stimulate increased thermogenesis and fat burning.13 Salicylic acid increases the thermogenic actions of ephedrine and caffeine by inhibiting feedback control mechanisms that block higher levels of thermogenesis. The combination of a salicylate compound, ephedrine and caffeine has produced close to five pounds a week of weight loss without dieting.14 In one study researchers found that people taking salicylate in conjunction with ephedrine and caffeine lost three times as much weight as those taking a placebo (4.8 pounds vs 1.5 pounds).15 In animal studies, the increase in energy expenditure found during treatment with ephedrine alone was doubled, and the obese group lost greater than 75% of body fat.16
